TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients&amp;rsquo; survival

Xiao, Wen; Wang, Xuegang; Wang, Tao; Xing, Jinchun

doi:10.2147/cmar.s185270

Cited by 27 publications

(24 citation statements)

References 36 publications

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“…The Kaplan-Meier (KM) curve evaluated survival rate for patients clinical and expression level of BMP1 with logrank test. Prognostic significance of BMP1 was analyzed by univariate and multivariate Cox proportional hazard regression in ccRCC as previously described [21]. All objects are greater than or equal to three for statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

Xiao

Wang

et al. 2019

Cancer Gene Ther

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Clear cell renal cell carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of renal cell carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group of cancer-related proteins in multiple pathogenesis of cancers. Currently, little is known about the prediction role of BMPs in ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information and BMP family expression data. Multivariate analysis showed that high expression of BMP1 was associated with shorter overall survival (OS) (P = 0.001), and shorter disease-free survival (DFS) (P = 0.018). Gene set enrichment analysis (GSEA) showed BMP1 was associated with epithelial-mesenchymal transition (EMT), G2M checkpoint, angiogenesis, hypoxia pathway, and Kirsten rat sarcoma viral oncogene (KRAS) signaling. Knockdown BMP1 suppressed malignancy of ccRCC in vitro and in vivo. Our results indicated that high expressions of BMP1 were poor prognostic factors and gene therapy could be an effective treatment for ccRCC.

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Section: Discussionmentioning

confidence: 99%

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

Xiao

Wang

et al. 2019

Cancer Gene Ther

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“…These TRIMs are often associated with unfavorable prognosis and promote cancer cells proliferation and migration, being often associated with proteins of central signaling pathways. On the other side, TRIMs like TRIM2 [86], TRIM3 [87,88], TRIM15 [89,90], TRIM26 [91], TRIM36 [92] TRIM45 [93], TRIM50 [94], TRIM58 [95,96], and TRIM62 [97] exert a tumor suppressor role, inhibiting cell proliferation and migration as well as promoting apoptosis. Finally, other TRIMs like TRIM32 [98,99,100] and TRIM44 play both an oncogenic and tumor suppressor role in different tumors [101,102,103,104,105,106,107].…”

Section: Trims and Cell Cycle Progressionmentioning

confidence: 99%

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

Venuto

Merla

2019

Cells

112

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The cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators. In eukaryotes, DNA replication is confined to a discrete synthesis phase while chromosome segregation occurs during mitosis. During mitosis, the chromosomes are pulled into each of the two daughter cells by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin. These four functional units tie chromosomes to the microtubules, send signals to the cells when the attachment is completed and the division can proceed, and withstand the force generated by pulling the chromosomes to either daughter cell. Protein ubiquitination is a post-translational modification that plays a central role in cellular homeostasis. E3 ubiquitin ligases mediate the transfer of ubiquitin to substrate proteins determining their fate. One of the largest subfamilies of E3 ubiquitin ligases is the family of the tripartite motif (TRIM) proteins, whose dysregulation is associated with a variety of cellular processes and directly involved in human diseases and cancer. In this review we summarize the current knowledge and emerging concepts about TRIMs and their contribution to the correct regulation of cell cycle, describing how TRIMs control the cell cycle transition phases and their involvement in the different functional units of the mitotic process, along with implications in cancer progression.

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“…Standard surgical resection is used for localized tumors. Patients with metastatic cancer benefit from chemotherapy based on the tyrosine kinase inhibitor (e.g., cabozantinib, sunitinib) (XIao et al, 2018; Yu et al, 2018).…”

Section: H4r Expression In Urinary Tract Cancersmentioning

confidence: 99%

Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications

2019

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Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor response and severe toxicity. Thus, the challenge for the new therapeutic approaches is to increase anti-tumor efficacy by targeting different molecules encompassed in the tumor and its microenvironment, as well as their specific interactions. The histamine H4 receptor (H4R) is the last discovered histamine receptor subtype and it modulates important immune functions in innate and in adaptive immune responses. Several ligands have been developed and some of them are being used in clinical trials for immune disorders with promising results. When searched in The Cancer Genome Atlas (TCGA) database, human H4R gene was found to be expressed in bladder cancer, kidney cancer, breast cancer, gastrointestinal cancers, lung cancer, endometrial cancer, and skin cancer. In the present work, we aimed to briefly summarize current knowledge in H4R’s pharmacology and in the clinical use of H4R ligands before focusing on recent data reporting the expression of H4R and its pathophysiological role in cancer, representing a potential molecular target for cancer therapeutics. H4R gene and protein expression in different types of cancers compared with normal tissue as well as its relationship with patient prognosis in terms of survival will be described.

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TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survival

Cited by 27 publications

References 36 publications

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications

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