TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells

Abstract

Background Although tripartite motif-containing protein 11 (TRIM11) is known to be associated with a variety of cancers, its role in nasopharyngeal carcinoma (NPC) is unclear. Methods and results To investigate the role of TRIM11 in NPC, TRIM11 was stably overexpressed in 6–10B and CNE2 cells with lentiviral vectors and knocked down in S18 and 5–8F cells using the CRISPR/Cas9 system. Transwell assays and wound-healing assays revealed that TRIM11 facilitated the migration and invasion of NPC cells. Mechanistically, we found that p53 inhibits TRIM11 expression by binding to its promoter. Conclusions TRIM11 may serve as a potential diagnostic marker for NPC and has a certain therapeutic value.

TRIM11 promotes cell proliferation of non‐small cell lung cancer through the inhibition of ferroptosis by AMPK

“…Furthermore, patients with high TRIM11 expression had lower survival rates. Previous research by Zhao et al also showed that TRIM11 facilitated the migration and invasion of nasopharyngeal carcinoma cells 28 . These results suggest that TRIM11 is upregulated in NSCLC and that inhibiting TRIM11 may offer protection against this disease.…”

“…Previous research by Zhao et al also showed that TRIM11 facilitated the migration and invasion of nasopharyngeal carcinoma cells. 28 These results suggest that TRIM11 is upregulated in NSCLC and that inhibiting TRIM11 may offer protection against this disease. In this study, we only analyzed the serum expression of TRIM11, which was one insufficient for this experiment.…”

“…Shang et al have identified that TRIM11 suppresses ferritinophagy of pancreatic ductal adenocarcinoma. 28 GPX4 is produced on the cell membrane and can directly reduce the level of phospholipid peroxide. 34 When the activity of GPX4 decreases, it cannot inhibit the production of ROS in the cell, resulting in the accumulation of lipid peroxide and the production of lethal ROS, thus inducing cell ferroptosis.…”

“…We have revealed that the TRIM11 gene promotes cell proliferation and reduces ROS‐induced ferroptosis of NSCLC. Shang et al have identified that TRIM11 suppresses ferritinophagy of pancreatic ductal adenocarcinoma 28 …”

“…Shang et al have identified that TRIM11 suppresses ferritinophagy of pancreatic ductal adenocarcinoma. 28 …”