Triküspit Kalp Kapakçıklarının Üç Boyutlu (3B) Biyobaskı Metotları ile Fabrikasyonu

Akpek, Ali

doi:10.19113/sdufbed.57066

Cited by 4 publications

(6 citation statements)

References 18 publications

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“…Hasta anatomisini doğru şekilde yansıtan 3B materyallerin ameliyat öncesi ve sırasında cerrahlara kılavuzluk ettiği ve girişimin süresini kısaltmaya yardımcı olduğu vurgulanmaktadır 35,36 .…”

Section: B Yazıcı Materyallerinin Cerrahi Alanda Kullanımıunclassified

“…Cerrahideki kullanım alanlarından bir diğeri olan doku ve organ üretimine yönelik çalışmalarda cilt, kemik, kalp dokuları, vasküler greftler, trakeal splint dokuları üretilirken, bu teknolojinin aynı zamanda aort damarı dokusunun geliştirilmesinde ve triküspit kalp kapağı üretiminde de kullanılabileceği keşfedilmiştir 30,36 .…”

Section: B Yazıcı Materyallerinin Cerrahi Alanda Kullanımıunclassified

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3 Boyutlu Yazıcı Materyallerinin Cerrahi ve Hemşirelik Alanında Kullanımına Bakış

ÖZTEPE YEŞİLYURT

2023

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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Son yıllarda bilgisayar yazılımlarındaki gelişmelerle birlikte, üç boyutlu yazıcıların farklı sektörlerdeki kullanımları daha sık gündeme gelmiş ve yaygınlıkları artmıştır. Günümüzde ise üç boyutlu baskı materyalleri sağlık alanında; özellikle cerrahi uygulamalarda, implant-doku tasarımlarında, eczacılık alanında, biyo baskı organ üretimi ve medikal enstrüman üretimlerinde yaygın olarak kullanılmakta, bunun yanında tıp-sağlık eğitimi gibi alanlarda ve sağlık bakım hizmetlerinde de yer almaktadır. Bu derlemede, üç boyutlu yazıcı materyallerinin sağlık alanındaki kullanım alanlarının açıklanması, cerrahi ve hemşirelik alanındaki kullanımının etkinliğinin incelenmesi amaçlanmıştır. Üç boyutlu yazıcı materyalleri kullanılarak verilen hemşirelik eğitimleri ile hemşirelerin daha teknik ve donanımlı hale gelerek, beceri kazanabilecekleri yönünde olumlu etkilerinin olacağı öngörülmektedir. Cerrahi alanda ise, üç boyutlu yazıcı materyallerinin öğrenci eğitimlerinde kullanımları sonucunda, özellikle zorlayıcı anatomik ve patolojik koşullarda öğrenmeyi daha iyi geliştirdiği ve eğitimlerin daha iyi anlaşıldığı, kadavra malzemeleriyle karşılaştırıldığında ise üç boyutlu yazıcı materyallerinin daha ucuz olduğu ve eğitimlerde insan dokusu yerine kullanılabileceği sonucuna ulaşılmıştır. Cerrahi ve hemşirelik alanındaki eğitimlerde; üç boyutlu yazıcı materyallerine daha kolay ulaşılabilmesi, eğitim uygulamalarında bu materyallerin etkinliğinin vurgulanması, materyallerin kullanımının artırılabilmesi açısından önemlidir.

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Section: B Yazıcı Materyallerinin Cerrahi Alanda Kullanımıunclassified

3 Boyutlu Yazıcı Materyallerinin Cerrahi ve Hemşirelik Alanında Kullanımına Bakış

ÖZTEPE YEŞİLYURT

2023

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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“…Examples include; 3D printer, Melt Accumulation Modeling (FDM), Laser Light Curing (SLA), Layer-to-Floor Object Manufacturing (LOM), Selective Laser Sintering (SLS) / Selective Laser Melting (SLM). When the literature is examined, 3D printing technologies are used in many different fields such as medicine (Aydın and Küçük, 2017), (Akpek, 2017), education (Demir et al, 2016), (Novak, 2019), architecture , construction and food industry (Lille et al, 2018).…”

Section: Fdm Technology Has Many Application Areasmentioning

confidence: 99%

Design And Manufacture Of Continuous Automatic 3D Printing Device With Conveyor System By İmage Processing Technology

Özsoy

Aksoy²,

Yücel³

2020

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In parallel with the technological developments, especially manufacturing and automation, many areas are experiencing new developments in the all world. These revolutionary technological developments are mentioned with different names (4th industrial revolution, digital transformation, etc.) and new inventions are present under different disciplines. Among all these developments, the most important advancements are the field of manufacturing. In recent years, 3D printing technologies can be said to have noteworthy studies in many countries. 3D printing technologies make it easy to manufacture complex parts. Although 3D printing is a new technology, it has been rapidly spreading in many other sectors, especially in education. However, these devices have a significant disadvantage. 3D printing technologies depend on a user. After the manufactured part, the parts need to be removed from the manufacture table for a new manufacturing. This prevents 3D printing technologies from becoming a mass production tool. In this study, design and manufacturing of the continuous automatic 3D printing device based on image processing method with the conveyor system will be performed. Also, the error rate of the surface quality of the samples was determined by the image processing method. Due to the ability to print continuously without user intervention, it will be increased the capacity and the functionality of the manufacture volume of 3D printing technologies.

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“…In tissue engineering, attempts have been made to produce tissue engineering heart valves using natural polymers such as collagen, hyaluronic acid, alginate, or gelatin, and synthetic polymers such as polycaprolactone, polyglycolic acid, and poly L-lactic acid, by printing methods such as 3D bioprinting, stereolithography, and electrospinning [ 7 , 8 , 9 , 10 ]. However, it has been reported that the artificial heart valves obtained due to the defects such as secondary structure change, great variability from batch to batch, and inadequate mechanical properties of the polymers used could not show sufficient efficiency in terms of both functional and bioresistance [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of Their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

2023

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In order to overcome the disadvantages of existing treatments in heart valve tissue engineering, decellularization studies are carried out. The main purpose of decellularization is to eliminate the immunogenicity of biologically derived grafts and to obtain a scaffold that allows recellularization while preserving the natural tissue architecture. SD and SDS are detergent derivatives frequently used in decellularization studies. The aim of our study is to decellularize the pulmonary heart valves of young Merino sheep by using low-density SDS and SD detergents together, and then to perform their detailed characterization to determine whether they are suitable for clinical studies. Pulmonary heart valves of 4–6-month-old sheep were decellularized in detergent solution for 24 h. The amount of residual DNA was measured to determine the efficiency of decellularization. Then, the effect of decellularization on the ECM by histological staining was examined. In addition, the samples were visualized by SEM to determine the surface morphologies of the scaffolds. A uniaxial tensile test was performed to examine the effect of decellularization on biomechanical properties. In vitro stability of scaffolds decellularized by collagenase treatment was determined. In addition, the cytotoxic effect of scaffolds on 3T3 cells was examined by MTT assay. The results showed DNA removal of 94% and 98% from the decellularized leaflet and pulmonary wall portions after decellularization relative to the control group. No cell nuclei were found in histological staining and it was observed that the three-layer leaflet structure was preserved. As a result of the tensile test, it was determined that there was no statistically significant difference between the control and decellularized groups in the UTS and elasticity modulus, and the biomechanical properties did not change. It was also observed that decellularized sheep pulmonary heart valves had no cytotoxic effect. In conclusion, we suggest that the pulmonary valves of decellularized young Merino sheep can be used as an initial matrix in heart valve tissue engineering studies.

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Triküspit Kalp Kapakçıklarının Üç Boyutlu (3B) Biyobaskı Metotları ile Fabrikasyonu

Cited by 4 publications

References 18 publications

3 Boyutlu Yazıcı Materyallerinin Cerrahi ve Hemşirelik Alanında Kullanımına Bakış

3 Boyutlu Yazıcı Materyallerinin Cerrahi ve Hemşirelik Alanında Kullanımına Bakış

Design And Manufacture Of Continuous Automatic 3D Printing Device With Conveyor System By İmage Processing Technology

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of Their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

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