Tri̇i̇yodoani̇li̇n’i̇n Sentezlenmesi̇, Nanosüspansi̇yonlarinin Hazirlanmasi, i̇n Vi̇tro Karakteri̇zasyonu Ve Radyokontrast Özelli̇kleri̇ni̇n İncelenmesi̇

Koca, Mehmet; Özakar, Emrah; Özakar, Rukiye Sevinç

doi:10.33483/jfpau.811737

Cited by 1 publication

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“…PDI gives information about the width of the particle size distribution, and the large size distribution can cause stability problems. A PDI value of 0.1-0.25 indicates a narrow distribution, while a PDI value greater than 0.5 indicates an extensive size distribution [30,22]. When our PDI results were examined, our values in the range of 0.181±0.019-0.228±0.006 were below 0.25, which means that the distribution is narrow.…”

Section: Zetasizer Analysis Of Nanoemulsionsmentioning

confidence: 79%

Kombi̇ne Sali̇si̇li̇k Asi̇t Ve Povi̇don-İyot İçeren Nanoemüljelleri̇n Hazirlanmasi Ve Karakteri̇zasyonu: Ön Çalişma

Özakar

ASAN

ÖZKAN

et al. 2022

Ankara Ecz. Fak. Derg.

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Objective: The aim of this preliminary study is to prepare and characterize combined salicylic acid and povidone-iodine-containing nanoemulgels for use in disease models such as wounds and burns in the future. Material and Method: Within the scope of the study, first of all, analytical method validation of salicylic acid was performed. Then, oil solubility studies were carried out and nanoemulsions and nanoemulgels were prepared. Morphology, zetasizer analysis, type and pH determination, FTIR analysis, spreadability, and in vitro release studies were performed to determine the characterization of the formulations. Result and Discussion: Nanoemulsions and nanoemulgels have been prepared successfully. Nanoemulsions with spherical droplet structure and outer phase water were obtained, and their morphology and zeta sizer results were compatible. In the 1-month stability study, only the F1 formulation did not decompose. There was not much change in pH after holding. At the end of the FTIR analysis, it was seen that there was no interaction between the items. In the release study performed with pH 5.5 phosphate buffer, approximately 40% of the release occurred after 8 hours. This study is a preliminary study, and formulations with long-term stability and release rate can be developed by conducting more detailed studies in the future. Salicylic acid and povidone-iodine were used in combination for the first time. This combination can be translated into formulations that may be beneficial for skin diseases in the future.

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Section: Zetasizer Analysis Of Nanoemulsionsmentioning

confidence: 79%