Triiodothyronine maintains cardiac transverse-tubule structure and function

Gilani, Nimra; Wang, Kaihao; Muncan, Adam; Peter, Jerrin; An, Shimin; Bhatti, Simran; Pandya, Khushbu; Zhang, Youhua; Tang, Yi-Da; Gerdes, A. Martin; Stout, Robert D.; Ojamaa, Kaie

doi:10.1016/j.yjmcc.2021.06.010

Cited by 10 publications

(5 citation statements)

References 81 publications

(110 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although TSH is considered to be the most sensitive marker for thyroid function [4], low circulating FT3 is the most frequently encountered thyroid functional test abnormality seen in CKD patients [11]. The HD patients enrolled in the present study were restricted to those with normal TSH, though it is becoming increasingly recognized that serum FT3 is more important than serum TSH for evaluating thyroid gland function because of its direct action in the target tissue [22]. A previous study also showed that the serum FT3/FT4 ratio clearly indicates a reduction in thyroid function in affected patients and the severity of low T3 syndrome [23].…”

Section: Discussionmentioning

confidence: 99%

Association of Reduced Free T3 to Free T4 Ratio with Lower Serum Creatinine in Japanese Hemodialysis Patients

Inaba¹,

Mori

Tsujimoto

et al. 2021

Nutrients

View full text Add to dashboard Cite

Purpose: Low T3 syndrome is defined by a fall in free triiodothyronine (FT3) in spite of normal serum thyroid-stimulating hormone (TSH) and often normal free thyroxin (FT4). A low FT3/FT4 ratio, a relevant marker for low T3 syndrome, is known as a risk of mortality in hemodialysis (HD) patients, as well as low muscle mass in the general population. Because of the local activation of T4 to FT3 in muscle tissue, we examined the association of FT3/FT4 ratio with serum creatinine, a marker of muscle mass and strength in HD patients to investigate the significance of muscle tissue in the development of low T3 syndrome in HD patients. Methods: This was a cross-sectional study derived from our prospective cohort study, named DREAM, of Japanese HD patients. After the exclusion of patients with treated and untreated thyroid dysfunction, 332 patients were analyzed in the study. Results: The serum FT4 and TSH of HD patients (n = 332) were 0.9 ± 0.1 ng/dL. and 2.0 ± 0.9 μIU/mL, which were within the respective normal range, while serum FT3 was 2.2 ± 0.3 pg/mL. As many as 101 out of 332 (30.4%) HD patients exhibited a serum FT3 less than the normal lower limit of 2.2 pg/mL. The serum FT3/FT4 ratio correlated significantly positively with serum creatinine, and inversely with serum log CRP and total cholesterol, while it exhibited a tendency towards positive correlation with serum albumin. Multiple regression analysis, which included serum creatinine, albumin, and log CRP, simultaneously, in addition to sex, age, diabetic kidney disease or not, log HD duration, body mass index, systolic blood pressure, and Kt/V, as independent variables, revealed an independent and significant positive association of serum creatinine, but not serum albumin or CRP, with the serum FT3/FT4 ratio. Conclusions: The present study demonstrated an independent and positive correlation of serum creatinine with the serum FT3/FT4 ratio in HD patients. The lack of association of the serum FT3/FT4 ratio with serum albumin and CRP suggested the presence of a creatinine-specific mechanism to associate with serum FT3/FT4 ratio. Because of the local activation of T4 to T3 at muscle tissue, a lower muscle mass may be causatively associated with low T3 syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Reduced Free T3 to Free T4 Ratio with Lower Serum Creatinine in Japanese Hemodialysis Patients

Inaba¹,

Mori

Tsujimoto

et al. 2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…The results of this study revealed an association between TH deficiency, disorganized T tubules, and reduced RYR2 cluster size/number. TH treatment increased the expression of junctophilin2 ( JPH2) as the critical regulator of cardiac dyad structure, and enhanced T-tubules network and RYR2 organization ( 81 ).…”

Section: Signaling Pathways Potentially Associated With Human Induced...mentioning

confidence: 99%

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation

Hamledari

Asghari

Jayousi

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiovascular diseases are the leading cause of mortality and reduced quality of life globally. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a personalized platform to study inherited heart diseases, drug-induced cardiac toxicity, and cardiac regenerative therapy. However, the immaturity of CMs obtained by current strategies is a major hurdle in utilizing hiPSC-CMs at their fullest potential. Here, the major findings and limitations of current maturation methodologies to enhance the utility of hiPSC-CMs in the battle against a major source of morbidity and mortality are reviewed. The most recent knowledge of the potential signaling pathways involved in the transition of fetal to adult CMs are assimilated. In particular, we take a deeper look on role of nutrient sensing signaling pathways and the potential role of cap-independent translation mediated by the modulation of mTOR pathway in the regulation of cardiac gap junctions and other yet to be identified aspects of CM maturation. Moreover, a relatively unexplored perspective on how our knowledge on the effects of preterm birth on cardiovascular development can be actually utilized to enhance the current understanding of CM maturation is examined. Furthermore, the interaction between the evolving neonatal human heart and brown adipose tissue as the major source of neonatal thermogenesis and its endocrine function on CM development is another discussed topic which is worthy of future investigation. Finally, the current knowledge regarding transcriptional mediators of CM maturation is still limited. The recent studies have produced the groundwork to better understand CM maturation in terms of providing some of the key factors involved in maturation and development of metrics for assessment of maturation which proves essential for future studies on in vitro PSC-CMs maturation.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Low triiodothyronine (T3) syndrome, also known as euthyroid disease syndrome (ESS) or non-thyroid disease syndrome (NTIS), is characterized by decreased peripheral T3 concentration and normal thyroid stimulating hormone (TSH), on behalf of the thyroid hormone metabolism changes [ 8 ], common in severe patients, as well as some acute and chronic disease patients. Low T3 syndrome is generally associated with cardiovascular disease (CVD) and increased risk of death [ 8 ], which is often observed in acute myocardial infarction, is associated with myocardial injury and poor prognosis [ 9 – 11 ], and is also associated with high mortality in hospitalized patients with heart failure [ 12 ]. More and more evidence indicates that low T3 syndrome is a predictor of poor prognosis in patients with community acquired pneumonia [ 13 ], suppurative liver abscess [ 14 ], hemodialysis (HD) [ 15 ], autoimmune encephalitis (AE) [ 16 ], and brain tumor surgery [ 17 ] and is also associated with hemorrhagic transformation in patients with acute ischemic stroke [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Low T3 syndrome as a predictor of poor outcomes in patients with follicular lymphoma

et al. 2023

View full text Add to dashboard Cite

The aim of this study was to investigate the prognostic value of low T3 syndrome in follicular lymphoma (FL). A total of 221 FL patients with detailed serum thyroid hormone levels and other complete clinical data were enrolled. Baseline features associated with low T3 syndrome were analyzed and balanced by propensity score matching. Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated to assess the predictive accuracy of FL international prognostic index FLIPI-1/FLIPI-2 and low T3 syndrome. A total of 22 patients (10.0%) had low T3 syndrome at diagnosis, which was associated with poor PFS and OS in the rituximab era. It is an independent prognostic factor for PFS and OS. Low T3 syndrome and FLIPI-1/FLIPI-2 significantly increased the AUC of PFS and OS compared to FLIPI-1/FLIPI-2 alone. Low T3 is a risk factor for POD24. In conclusion, low T3 syndrome may be a good candidate for predicting the prognosis of CLL in future clinical practice. Our study demonstrates that low T3 syndrome is associated with poorer survival outcomes in FL patients. Supplementary Information The online version contains supplementary material available at 10.1007/s00277-023-05117-5.

show abstract

Triiodothyronine maintains cardiac transverse-tubule structure and function

Cited by 10 publications

References 81 publications

Association of Reduced Free T3 to Free T4 Ratio with Lower Serum Creatinine in Japanese Hemodialysis Patients

Association of Reduced Free T3 to Free T4 Ratio with Lower Serum Creatinine in Japanese Hemodialysis Patients

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation

Low T3 syndrome as a predictor of poor outcomes in patients with follicular lymphoma

Contact Info

Product

Resources

About