Trigonal‐bipyramidale Technetium‐ und Rhenium‐Komplexe mit vierzähnigen tripodalen NS₃‐Liganden

Abstract

Fünffach koordiniertes Rhenium oder Technetium ist in den trigonal‐bipyramidalen Komplexen des Typs 2 enthalten. Neutrale MIII‐Komplexe dieser Geometrie werden aus den Permetallaten MO oder aus oktaedrischen MIII‐Spezies mit dem vierzähnigen, tripodalen Liganden 1 erhalten. Der einzähnige Ligand R din den Komplexen 2 läßt sich leicht austauschen.magnified image

Central vs. peripheral Ag(i) coordination in NS3-open chain and cage ligands

“…Recently, Ambundo et al introduced an open chain tetradentate tripodal ligand based on a NS 3 donor set for the complexation of Cu(). 6 An analogous compound has been described earlier for Cu() by Suzuki et al 7 and for Tc() by Spies et al 8 Their coordinating properties towards Ag() had not been investigated so far, but we expected a comparable coordination chemistry with Ag(), a higher homologue of Cu(). In a first section, we present herein several open chain ligands and cage compounds bearing this ethylene-bridged NS 3 -moiety.…”

“…As to approach more potent ligands, we performed DFT calculations on model compounds and followed conclusions of analogy on literature NS 3 -ligands. [6][7][8] This resulted in the synthesis of a novel NS 3 -metacyclophane and the investigation of its coordinating properties towards Ag(), which are presented in a second section of this article.…”

Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues

“…1b). These types of complex require the synthesis of o-isocyano-functionalized FAs [11,15]. Because of the instability of the free isonitrile-substituted acids, a conversion of the carboxylic acid group to a methyl ester function is necessary during the syntheses of ligand and complex.…”

“…The synthesis of the '3 + 1' and '4 + 1' mixed-ligand complexes has been published recently [11][12][13][14][15][16]. The preparation of the '3 + 1' 99m Tc complexes follows a onestep procedure as described before [13], with reduction of the pertechnetate with stannous(II) chloride, in the presence of the monodentate FA thiol and the tridentate ligand of choice, with propylene glycol as a co-solvent.…”

“…Starting with the FA infusion, the complete venous effluent perfusate was collected in 12 consecutive samples of 15 s each (samples 1-12). After ceasing the radioactivity infusion another four samples during sole KHB perfusion were collected (rinse from the remaining radiolabelled substances; samples [13][14][15][16]. A eff was taken to equal the sum of the radioactivity recovered from these 16 effluent perfusate samples corrected for background activity.…”