Triglycerol-based hyperbranched polyesters with an amphiphilic branched shell as novel biodegradable drug delivery systems

Abstract

A set of biodegradable nanocarriers characterized by a hyperbranched polyester core and an amphiphilic branched shell was developed and employed to efficiently solubilize hydrophobic drugs in aqueous media.

Self-Assembly Behavior and pH-Stimuli-Responsive Property of POSS-Based Amphiphilic Block Copolymers in Solution

“…Drug release is an important application for responsive polymer, and the preparation of fluorescent molecules is the primary means to evaluate drug release efficiency [ 32 , 33 , 34 , 35 ]. Herein, the release of pyrene as a drug model from the micelles by adjusting the pH value is investigated.…”

Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

“…Dendritic polymeric architectures derived from polyglycerol (PG) have been extensively used in the design of scaff olds in several biomedical applications. [50][51][52] Due to their highly biocompatible nature, dendritic PGs (dPGs) show a broad range of potential applications in medicine and pharmacology, as well as the release of bioactive molecules in regenerative medicine in the form of nonfouling surfaces and matrix materials. The presence of amine groups on the surface or focal point in polyglycerol (PG) architectures has proved to be useful for provid-ing an anchoring point in the preparation of protein resistant surfaces, 53,54 in the synthesis of polyglycerol (PG)-based peptide conjugates, 55 macromolecular prodrugs (compounds that, after administration in the body, are converted into a pharmacologically active drug) and in the condensation of nucleic acid drugs.…”

Dendritic Oligoglycerol Regioisomer Mixtures and Their Utility for Membrane Protein Research

“…The sum of these advantageous properties makes dendritic oligoglycerol a valuable starting material for structure–property studies. Dendritic oligoglycerol has been used for the production of dendronized polymers, [6] unimolecular micelles, [7] and dendritic OGDs [2] . The first dendritic OGDs were reported by Wyszogrodzka and co‐workers in 2008 [8] .…”