Triglycerides and total cholesterol concentrations in association with IFG/IGT in Chinese adults in Qingdao, China

Cui, Jing; Sun, Jianping; Wang, Wei; Yasmeen, Nafeesa; Ma, Ke; Xin, Hualei; Qiao, Qing; Ma, Aiguo; Baloch, Zulqarnain

doi:10.1186/s12889-018-5286-z

Cited by 9 publications

(11 citation statements)

References 32 publications

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“…It was demonstrated by cohort studies that WC was an independent factor that is associated with the risk of cardiovascular diseases [56–58]. On the other hand, a significant relation was available between TG concentrations and insulin resistance [59] and the increased TG was independently associated with the risk of hypertension, diabetes, and IFG [60, 61]. Moreover, TG was demonstrated to be significantly associated with VAT in healthy men, even after controlling for SAT [62].…”

Section: Discussionmentioning

confidence: 99%

Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey

Song

Xue

Jiang

et al. 2019

Journal of Diabetes Research

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Aims Lipid accumulation product (LAP) is put forward as a powerful marker showing the accumulation of visceral fat. The present study is aimed at (i) analyzing the predictive performances of LAP in the identification of impaired fasting glucose (IFG) in Chinese population and (ii) exploring the potentially interactive effect between LAP and other factors on IFG risk. Methods Analysis was conducted on the data obtained from a community-based cross-sectional survey in Chinese population, and all the participants enrolled were required to complete a face-to-face questionnaire survey and related health checks. Then, for the purpose of comparing predictive values between LAP and conventional obesity indices for IFG, relevant analysis was carried out on the receiver operating characteristic (ROC) curve. The assessment of interactive effects was conducted by employing the three indicators as follows: (1) RERI (the relative excess risk due to interaction), (2) AP (attributable proportion due to interaction), and (3) SI (synergy index). Results A total of 1777 participants (748 males and 1029 females) were involved in the final analysis. It was finally obtained that the prevalence rate of IFG was 14.1% in total, 15.5% for males and 13.1% for females, respectively. In logistic regression analysis, individuals with LAP levels in the fourth quartile had a significant higher risk of getting IFG in comparison with that of the lowest quartile (crude OR: 4.58, 95% CI: 3.01-6.98; adjusted OR: 3.81, 95% CI: 2.33-6.23). In addition, it was indicated by the ROC curve analysis that LAP showed a better performance in discriminating IFG risk than BMI in both males (Z = 2.20, P = 0.028) and females (Z = 2.13, P = 0.033). However, LAP displayed a higher predictability in comparison with WC only in females (Z = 2.07, P = 0.038), but not in males (Z = 0.18, P = 0.860). Furthermore, LAP and family history of diabetes were able to impose significant synergistic interaction on the risk of IFG, which was indicated by all the parameters in females (RERI: 2.52, 95% CI: 0.19-4.84; AP: 0.47, 95% CI: 0.20-0.74; SI: 2.39, 95% CI: 1.17-4.87) and males (RERI: 2.18, 95% CI: 0.08-4.73; AP: 0.43, 95% CI: 0.07-0.79; SI: 2.15, 95% CI: 1.03-5.45). However, none of the indicators showed significant interaction between LAP and smoking on the risk of IFG in females (RERI: 0.92, 95% CI: -2.79-4.63; AP: 0.20, 95% CI: -0.50-0.92; SI: 1.37, 95% CI: 0.42-4.52). Meanwhile, there was also no significant interaction between LAP and smoking on the risk of IFG in males as indicated by the value of SI (2.22, 95% CI: 0.80-6.21). Conclusion It was concluded that LAP was significantly related to a higher risk of IFG in Chinese population, and its performance was superior to that of conventional obesity indices, especially in females. Apart from that, LAP with family history of diabetes may have an interactive effect that can impose a great influence on the development of IFG.

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Section: Discussionmentioning

confidence: 99%

Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey

Song

Xue

Jiang

et al. 2019

Journal of Diabetes Research

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“…In our study, LDL significantly did not increase linearly with age, which is in contrast to a population study in the United States. In overweight people, with increasing BMI, the level of LDL-C tends to be flat or decreased in males ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China

Zhu

Wang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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PurposeThe prevalence of cardiovascular diseases (CVDs) associated with lipid levels is increasing worldwide. Our purpose is to analyze the distribution level and influencing factors of lipid in the whole population and to put forward suggestions for preventing abnormal lipid levels.MethodsThe study was based on a sample of 91,480 Chinese who participated in a nationwide physical examination program in Wuhan, a midland city in China, in 2018. The distribution of blood lipid in the population was observed using average, and the relationship between the influencing factors and blood lipid level was observed by quantile regression (QR).ResultsA total of 91,480 people were evaluated in this study, among which 59,165 (64.68%) were female with a mean age of 51.71 ± 10.82 years. QR results showed that different physical examination indexes had different effects on lipid levels. Fasting plasma glucose (FBG) has the largest QR coefficient and BMI had positive effects on total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). In males, age has a positive influence on TC, LDL-C, and high-density lipoprotein cholesterol (HDL-C), while in females, age has a positive influence on all four indexes.ConclusionWe found that the TC and LDL-C levels of females were more susceptible to age than males, and the lipid levels of older females were higher than males. BMI has a greater effect on lipid levels in males than in females. Regardless of gender should pay attention to dyslipidemia caused by diabetes and abnormal liver function.

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“…Our previous study also found that elevated TG and TC was in association with metabolic syndrome. 33,34 Lanaspa et al, 35 have suggested that HUA is more prone to develop fatty liver, which generated elevated TG and TC. In addition, there are few mechanisms between uric acid metabolism and lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

<p>Triglycerides and Total Cholesterol Concentrations in Association with Hyperuricemia in Chinese Adults in Qingdao, China</p>

Cui¹,

Cui²,

Sun³

et al. 2020

RMHP

Self Cite

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Objective: To assess the association between triglycerides (TG), total cholesterol (TC) and hyperuricemia (HUA) in the general Chinese population. Methods: A population-based cross-sectional survey included 9680 participants aged 35-74 years in 2006 and 2009 in Qingdao, China. TG, TC and uric acid (UA) were measured. The logistic regression model was performed to estimate the association between TG, TC, and HUA with an odds ratio (OR) and 95% confidence intervals (CI). Meanwhile, age stratification analysis (<55 years group and ≥55 years group) was performed to evaluate whether age potentially affects the association between TG, TC and HUA using multivariable logistic regression. Results: Higher TG and TC showed significantly increased HUA prevalence in both men and women (P trend all <0.05). Multivariate logistic regression indicated that borderline high

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Triglycerides and total cholesterol concentrations in association with IFG/IGT in Chinese adults in Qingdao, China

Cited by 9 publications

References 32 publications

Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey

Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey

Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China

<p>Triglycerides and Total Cholesterol Concentrations in Association with Hyperuricemia in Chinese Adults in Qingdao, China</p>

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