Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey

Kwon, Yu‐Jin; Park, Jeong Won; Lim, Hyoung Ji; Lee, Yong Jae; Lee, Hye Sun; Shim, Jae Yong

doi:10.1007/s00784-017-2140-0

Cited by 8 publications

(10 citation statements)

References 32 publications

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“…This study showed that periodontitis is positively associated with a TG/HDL-C ratio ≥ 2.3, corroborating the previous study of Kwon et al, 32 conducted in Korea, using population data from the 2012-2014 Korean National Health and Nutrition Examination Survey -KNHANES. The present study also showed a positive association between periodontitis severity and the TG/HDL-C ratio ≥ 2.3.…”

Section: Discussionsupporting

confidence: 91%

“…43,44 It is known that age, sex, smoking habit, glycemic level, arterial hypertension and use of medication for dyslipidemia are factors that interfere when associating periodontitis with outcomes such as the TG/HDL-C ratio. 32 In addition, the number of visits to the dentist for treatment and prevention of oral disease, 45 as well as liver disease 46 has an influence on studied conditions. Finally, the confounding level of education, since the lower the number of years of study, the occurrence of both the exposure and the outcome is greater.…”

Section: Discussionmentioning

confidence: 99%

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Periodontitis and its higher levels of severity are associated with the triglyceride/high density lipoprotein cholesterol ratio

Filho

Santos

Cruz

et al. 2021

Journal of Periodontology

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Background: Periodontitis and the Triglyceride/High Density Lipoprotein Cholesterol (TG/HDL-C) ratio have both been associated with cardiovascular disease, metabolic syndrome, and obesity. Additionally, the ratio is a possible substitute for predicting insulin resistance. This study investigated the association between periodontitis, its severity levels (exposures), and the TG/HDL-C ratio (outcome). Methods: A cross-sectional study of public health service users in Brazil considered socioeconomic-demographic characteristics, lifestyle behavior, and general and oral health conditions. Anthropometric measurements and blood pressure were also measured. Systemic biomarker data were obtained, as well as assessment of periodontal diagnosis and its severity. The TG/HDL-C ratio was calculated using the serum triglyceride level over HDL cholesterol and the cut-off point, TG/HDL-C ≥2.3 serving as the cutoff indicting dyslipidemia. Logistic and linear regressions were used to statistically analyze the data.Results: A total of 1011 participants were included, with 84.17% having periodontitis and 49.85% having a TG/HDL-C ratio ≥2.3. For individuals with periodontitis, the odds of TG/HDL-C ratio ≥2.3 were 1.47 times greater than in those without periodontitis (OR Adjusted = 1.47, 95% CI: 1.02-2.14). Similar results were found for those with moderate and severe periodontitis, with a slight increase in the measurement magnitude with disease severity. Conclusion: A positive relationship between periodontitis and the TG/HDL-C ratio ≥2.3 was found, suggesting a possible association with periodontal disease severity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Periodontitis and its higher levels of severity are associated with the triglyceride/high density lipoprotein cholesterol ratio

Filho

Santos

Cruz

et al. 2021

Journal of Periodontology

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“…A recent study of 4813 participants in the National Health and Nutrition Examination Survey found that elevated TyG levels were associated with an increased risk of periodontitis in the US population. 27 Kwon et al 28 found that a higher TG/HDL-C ratio is associated with an increased prevalence of periodontitis in the Korean population using the same data set.…”

Section: Discussionmentioning

confidence: 98%

“…26 A recent study found that high TyG levels were associated with increased odds of periodontitis in the US population. 27 Kwon et al 28 found a significant association between TG/HDL-C ratio and the prevalence of periodontitis in the Korean population. No previous studies, however, have investigated the relationship between the METS-IR index and periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) associated with periodontitis in Korean adults

Lee

Kwon

2022

Therapeutic Advances in Chronic Disease

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Background: Periodontitis is one of the most common diseases associated with the oral cavity. Previous studies have suggested that there is an association between periodontitis and metabolic dysfunction. Recently, the triglyceride glucose (TyG) index, high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) index have been identified as useful markers for assessing insulin resistance. Objective: This study aimed to evaluate the relationship between periodontitis and non-insulin-based insulin resistance (IR) indices and compare the predictive values of these indices in the Korean population. Design: This is a cross-sectional study. Methods: A total of 13,584 participants were included in the 2013–2015 Korean National Health and Nutrition Examination Survey data. A community periodontal index score⩾3 was used to define periodontitis. Participants were divided into quartiles according to each index. Odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of periodontitis and the TyG index, TG/HDL-C ratio, and METS-IR index quartiles were calculated using multiple logistic regression analysis. We estimated the areas under the receiver operating characteristic curves (AUCs) of the indices to compare the predictive values of the three indices. Results: Compared with quartile 1, the fourth quartile ORs (95% CIs) for periodontitis were 1.23 (1.01–1.49) for the TyG index, 1.23 (1.02–1.48) for the TG/HDL-C ratio, and 1.53 (1.25–1.88) for the METS-IR index after adjustment for confounders. The AUC (95% CIs) was 0.608 (0.598–0.618) for the TyG index, 0.600 (0.590–0.610) for the TG/HDL-C ratio, and 0.617 (0.608–0.627) for the METS-IR index to identify periodontitis. The predictive power of METS-IR was significantly higher than that of the TyG index and TG/HDL-C. Conclusion: Higher TG/HDL-C ratio, TyG, and METS-IR indices are associated with a higher prevalence of periodontitis. The METS-IR index is a more powerful predictor of periodontitis prevalence than the TyG index and TG/HDL-C ratio.

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“…[30] An association between periodontal disease and TG/HDL ratio was observed in Korean adults. [31] Lipids can alter the gene expression of macrophage to produce activated macrophage which in turn elevate the level of proinflammatory cytokines such as TNFα and IL1β and essential polypeptide growth factors such as platelet-derived growth factor and TGF1β. [3233] Furthermore, serum lipids irrespective of mode of induction can increase polymorphonuclear neutrophils (PMN) production and impair wound healing by inhibiting macrophage production of essential polypeptides growth factors.…”

Section: Evidence Based Overview Linking Periodontal Infection and Hymentioning

confidence: 99%

Critical appraisal of bidirectional relationship between periodontitis and hyperlipidemia

Abraham¹,

Premnath²,

Arunima³

et al. 2019

J Int Soc Prevent Communit Dent

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Periodontal disease and hyperlipidemia are both multifactorial disease with a high prevalence Worldwide. Cross-sectional and longitudinal prospective clinical studies show some evidence for a bidirectional relationship. Periodontitis and hyperlipidemia share some common risk factors and there exist a mechanistic link between both. Studies have found a positive response to periodontal therapy among hyperlipidemic patients, and statin use by hyperlipidemic patients has shown to influence the periodontal health. However, in spite of the rising prevalence of both diseases, many people remain unaware of their association with each other. Hence, this article summarizes the cyclic relationship between periodontal disease and hyperlipidemia.

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Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey

Abstract: TG/HDL-C ratio is a simple and useful marker to reflect insulin resistance. And periodontal disease is also known to be related with insulin resistance. This study indicates that TG/HDL-C ratio was associated with periodontal disease in Korean adults.

Cited by 8 publications

References 32 publications

Periodontitis and its higher levels of severity are associated with the triglyceride/high density lipoprotein cholesterol ratio

Periodontitis and its higher levels of severity are associated with the triglyceride/high density lipoprotein cholesterol ratio

Comparison of the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) associated with periodontitis in Korean adults

Critical appraisal of bidirectional relationship between periodontitis and hyperlipidemia

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