Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studies

Norata, Giuseppe Danilo; Grigore, Liliana; Raselli, Sara; Seccomandi, P.M.; Hamsten, Anders; Maggi, F.M.; Eriksson, Per; Catapano, Alberico L.

doi:10.1016/j.yjmcc.2006.01.022

Cited by 56 publications

(42 citation statements)

References 34 publications

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“…Significantly elevated levels of sICAM-1 were found in the obese children of this study with positive correlation with BMI, SBPHOMA-IR and LDL-C and with a negative correlation with HDL-C. A finding reported byNorata et alagreed with this and declared that the metabolic syndromecomponents already altered in obese children may induce the expression of cell adhesion molecules, promoting atherogenesis and may precipitate acute atherothrombotic events [39]. The positive correlation noted here between sICAM levels and both fasting insulin levels and HOMA-IR denotes that Insulin resistance has alsobeen associated with endothelial dysfunction in obese patients.…”

Section: Discussionsupporting

confidence: 73%

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Na¹,

Aa²,

Ma³

et al. 2017

IOSR JBB

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Section: Discussionsupporting

confidence: 73%

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Na¹,

Aa²,

Ma³

et al. 2017

IOSR JBB

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“…It has previously been shown that VLDL isolated from individuals with dyslipidaemia is proinflammatory and responsible for the upregulation of several pathways involved in endothelial activation [35]. Although the mechanisms behind this are poorly understood, the composition of the particle might play an important role.…”

Section: Discussionmentioning

confidence: 99%

Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes

et al. 2012

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Aims/hypothesis The aim of this study was to use lipidomics to determine if the lipid composition of apolipoprotein-Bcontaining lipoproteins is modified by dyslipidaemia in type 2 diabetes and if any of the identified changes potentially have biological relevance in the pathophysiology of type 2 diabetes. Methods VLDL and LDL from normolipidaemic and dyslipidaemic type 2 diabetic women and controls were isolated and quantified with HPLC and mass spectrometry. A detailed molecular characterisation of VLDL triacylglycerols (TAG) was also performed using the novel ozone-induced dissociation method, which allowed us to distinguish vaccenic acid (C18:1 n-7) from oleic acid (C18:1 n-9) in specific TAG species. Results Lipid class composition was very similar in VLDL and LDL from normolipidaemic type 2 diabetic and control participants. By contrast, dyslipidaemia was associated with significant changes in both lipid classes (e.g. increased diacylglycerols) and lipid species (e.g. increased C16:1 and C20:3 in phosphatidylcholine and cholesteryl ester and increased C16:0 [palmitic acid] and vaccenic acid in TAG). Levels of palmitic acid in VLDL and LDL TAG correlated with insulin resistance, and VLDL TAG enriched in palmitic acid promoted increased secretion of proinflammatory mediators from human smooth muscle cells. Conclusions We showed that dyslipidaemia is associated with major changes in both lipid class and lipid species composition in VLDL and LDL from women with type 2 diabetes. In addition, we identified specific molecular lipid species that both correlate with clinical variables and are proinflammatory. Our study thus shows the potential of advanced lipidomic methods to further understand the pathophysiology of type 2 diabetes.

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“…Furthermore, TRLs induced MCP-1 expression suggesting that the activation of the endothelium could support both adhesion and transmigration of leukocytes (Norata et al, 2006). As the induction of adhesion molecules and release of chemokines have been associated with endothelial dysfunction, it can be proposed that endothelial activation by TRL may promote endothelial dysfunction observed after a meal.…”

Section: Postprandial Lipoproteins and Endothelial Dysfunctionmentioning

confidence: 98%

Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach

López¹,

Ortega²,

Varela³

et al. 2008

Grasas y Aceites

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Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studies

Cited by 56 publications

References 34 publications

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes

Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach

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