Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

Li, Jing; Li, Liang; Guo, Dongming; Li, Suyun; Zeng, Yuxin; Liu, Chuhao; Fu, Rao; Huang, Min-Xian; Xie, Wei

doi:10.1016/j.cca.2019.12.029

Cited by 47 publications

(44 citation statements)

References 215 publications

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“…L-DD decreased the period of Scd1 and Scd2. The recent research illustrated Angptl3 and Angptl4 played important roles in lipid metabolism [40]. The presented study found that the expression of Angptl3 and Angptl4 showed circadian rhythm under LD and L-DD.…”

Section: Resultsmentioning

confidence: 55%

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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Background: The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the rhythm of endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT, C57BL/6 J mice were maintained under constant darkness (DD) for 6 weeks, and the liver samples were collected starting at 9:00 AM (CT1), and every 4 h in a 24-h cycle (CT5, CT9, CT13, CT17 and CT21). Total RNA was extracted and subjected to RNA-Seq data (deposited as GSE 133342, L-DD). To compare gene oscillation pattern under normal light-dark condition (LD, GSE114400) and short time (2 days) dark-dark condition (S-DD, GSE70497), these data were retried from GEO database, and the trimmed mean of M-values normalization was used to normalize the three RNA-seq data followed by MetaCycle analysis. Results: Approximate 12.1% of the genes under L-DD exhibited significant rhythmically expression. The top 5 biological processes enriched in L-DD oscillation genes were mRNA processing, aromatic compound catabolic process, mitochondrion organization, heterocycle catabolic process and cellular nitrogen compound mitotic catabolic process. The endogenous circadian rhythms of clock genes, P450 genes and lipid metabolism genes under L-DD were further compared with LD and S-DD. The oscillation patterns were similar but the period and amplitude of those oscillation genes were slightly altered. RT-qPCR confirmed the selected RNA sequence findings. Conclusions: This is the first study to profile oscillation gene expressions under L-DD. Our data indicate that clock genes, P450 genes and lipid metabolism genes expressed rhythmically under L-DD. Light was not the necessary factor for persisting circadian rhythm but influenced the period and amplitude of oscillation genes.

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Section: Resultsmentioning

confidence: 55%

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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“…Furthermore, our study observed linear associations of ANGPTL8 with all-cause mortality in diabetic patients. ANGPTL8 has been shown to be related to glucose and lipid metabolism in previous studies [29][30][31][32]. Our study, however, contributes new knowledge about the importance of ANGPTL8 in the prediction of health outcomes of diabetic patients, specifically for the prediction of death.…”

Section: Discussionmentioning

confidence: 69%

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: from the REACTION Study

Zou

Chen

et al. 2020

Preprint

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Background: ANGPTL8, an important regulator of glucose and lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role of ANGPTL8 in diabetes outcomes remains unclear. The study aimed to investigate circulating levels of ANGPTL8 in participants with and without diabetes and its potential association with death and cardiovascular and renal outcomes in a 5-year cohort study.Methods: Propensity-matched cohorts of subjects with and without diabetes from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A longitudinal (REACTION) study was generated on the basis of age, sex and body mass index at baseline. The primary outcome was death from any cause. The secondary outcome was a composite of new-onset major adverse cardiovascular events, hospitalization for heart failure and renal dysfunction (eGFR < 60/min/1.73 m2).Results: We identified 769 matched pairs of patients from the diabetes group and the control group. Serum ANGPTL8 levels were elevated in patients with diabetes compared to subjects in the control group (618.82 318.08 vs. 581.20 299.54, p = 0.03). Furthermore, increasing quartiles of ANGPTL8 were associated with increased all-cause mortality in both the control and diabetes groups (all p values < 0.05). Binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with greater risk ratios (RRs) of death (RR in quartile 4 vs quartile 1, 3.47; 95% CI 1.30 – 9.29) and renal dysfunction (RR in quartile 4 vs quartile 1, 10.50; 95% CI 1.32 – 83.60) only in diabetic patients. Multivariable-adjusted restricted cubic spline analyses suggested a significant linear relationship between ANGPTL8 and all-cause mortality in diabetic patients (p for nonlinear trend = 0.99, p for linear trend = 0.01) but not in the controls (p for nonlinear trend = 0.26, p for linear trend = 0.80). According to the ROC curves, the QMortality and QFrailty scores, combined with ANGPTL8, showed better performance in predicting death, especially in diabetic patients.Conclusion: Serum ANGPTL8 levels were associated with an increased risk for all-cause mortality and renal dysfunction in subjects with diabetes. Furthermore, ANGPTL8 had good performance in predicting all-cause mortality in diabetic patients, which may contribute to the early detection of individuals with diabetes at high risk.

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“…Both ANGPTL4 and ANGPTL8 inhibit LPL and can form complexes with ANGPTL3 and with each other. The ANGPTL4/ANGPTL8 complex is, however, less active than ANGPTL4 alone (Kovrov et al, 2019;Li et al, 2020); therefore, LPL activity would be predicted to decrease when ANGPTL8 expression is reduced. The gene encoding ATP binding cassette subfamily G member, ABCG8, was upregulated in IMBAL cows.…”

Section: Relationships Between Metabolic Profiles and Gene Expressionmentioning

confidence: 99%

Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation

Wathes

Cheng

Salavati

et al. 2021

Journal of Dairy Science

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Homeorhetic mechanisms assist dairy cows in the transition from pregnancy to lactation. Less successful cows develop severe negative energy balance (NEB), placing them at risk of metabolic and infectious diseases and reduced fertility. We have previously placed multiparous Holstein Friesian cows from 4 herds into metabolic clusters, using as biomarkers measurements of plasma nonesterified fatty acids, β-hydroxybutyrate, glucose and IGF-1 collected at 14 and 35 d in milk (DIM). This study characterized the global transcriptomic profiles of liver and circulating leukocytes from the same animals to determine underlying mechanisms associated with their metabolic and immune function.Liver biopsy and whole-blood samples were collected around 14 DIM for RNA sequencing. All cows with available RNA sequencing data were placed into balanced (BAL, n = 44), intermediate (n = 44), or imbalanced (IMBAL, n = 19) metabolic cluster groups. Differential gene expression was compared between the 3 groups using ANOVA, but only the comparison between BAL and IMBAL cows is reported. Pathway analysis was undertaken using DAVID Bioinformatic Resources (https: / / david .ncifcrf .gov/ ). Milk yields did not differ between BAL and IMBAL cows but dry matter intake was less in IMBAL cows and they were in greater energy deficit at 14 DIM (−4.48 v −11.70 MJ/d for BAL and IMBAL cows). Significantly differentially expressed pathways in hepatic tissue included AMPK signaling, glucagon signaling, adipocytokine signaling, and insulin resistance. Genes involved in lipid metabolism and cholesterol transport were more highly expressed in IMBAL cows but IGF1 and IG-FALS were downregulated. Leukocytes from BAL cows had greater expression of histones and genes involved in nucleosomes and cell division. Leukocyte expression of heat shock proteins increased in IMBAL cows, suggesting an unfolded protein response, and several key genes involved in immune responses to pathogens were upregulated (e.g., DEFB13, HP, OAS1Z, PTX3, and TLR4). Differentially expressed genes upregulated in IMBAL cows in both tissues included CD36, CPT1, KFL11, and PDK4, all central regulators of energy metabolism. The IMBAL cows therefore had greater difficulty maintaining glucose homeostasis and had dysregulated hepatic lipid metabolism. Their energy deficit was associated with a reduced capacity for cell division and greater evidence of stress responses in the leukocyte population, likely contributing to an increased risk of infectious disease.

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Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

Cited by 47 publications

References 215 publications

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: from the REACTION Study

Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation

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