Triglyceride-mediated pathways and coronary heart disease

Banerjee, Yajnavalka; Taranikanti, Varna; Bayoumi, Riad

doi:10.1016/s0140-6736(10)61447-x

Cited by 8 publications

(11 citation statements)

References 4 publications

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“…The inverse relationship between HDL-C and TG levels as observed in the present study is a well-known phenomenon and is thought to be due to the enhanced metabolism of TGenriched HDL particles. 28,29 The relationship between gender and HDL-C levels is a well-documented phenomenon with higher HDL-C levels expected among premenopausal women compared with men, and in this study cohort, the average age was well below the menopause age group. Increased estrogen levels in premenopausal women accounts for such an observation.…”

Section: Discussionmentioning

confidence: 70%

“…The inverse relationship between HDL-C and TG levels as observed in the present study is a well-known phenomenon and is thought to be due to the enhanced metabolism of TG-enriched HDL particles. 28,29…”

Section: Discussionmentioning

confidence: 99%

“…36 With the advent of cutting-edge sequencing techniques such as exome sequencing, one of our future endeavors will be to confirm whether there is a genetic association with regard to the observed variations in HDL-C. However, as the Omani population is relatively genetically homogenous, 29 this is unlikely.…”

Section: Limitationsmentioning

confidence: 99%

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The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol

et al. 2014

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Lower mortality rates from coronary heart disease and higher levels of serum high-density lipoprotein cholesterol (HDL-C) have been observed in populations residing at high altitude. However, this effect has not been investigated in Arab populations, which exhibit considerable genetic homogeneity. We assessed the relationship between residing altitude and HDL-C in 2 genetically similar Omani Arab populations residing at different altitudes. The association between the levels of HDL-C and other metabolic parameters was also investigated. The levels of HDL-C were significantly higher in the high-altitude group compared with the low-altitude group. Stepwise regression analysis showed that altitude was the most significant factor affecting HDL-C, followed by gender, serum triglycerides, and finally the 2-hour postprandial plasma glucose. This finding is consistent with previously published studies from other populations and should be taken into consideration when comparing cardiovascular risk factors in populations residing at different altitudes.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol

et al. 2014

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“…Sphingolipid profiling of lipoproteins showed that HDL contain also sphingosine-1-phosphate, sphinganine-1-phosphate, and sphingosine (Hammad et al, 2010;Scherer et al, 2011). Lysosphingolipids mediate atheroprotection via release of nitric oxide (Nofer et al, 2004;Shaul and Mineo, 2004), and can also mediate anticoagulation (Banerjee et al, 2010). The capacity of HDL to inhibit early events in the development of atherosclerosis, the production of Monocyte chemoattractant protein-1 and activation of NADPHoxidase involved in the generation of reactive oxygen species, appears to be mediated by sphingosine-1-phosphate and sphingosylphosphorylcholine present in HDL (Tölle et al, 2008).…”

Section: Lysosphingolipids and Heart Diseasementioning

confidence: 99%

A view on sphingolipids and disease

Kolter

2011

Chemistry and Physics of Lipids

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“…Additionally, factors identified in prior work from Europe and North America may not be assignable to other cultures. Case in point, the population of Oman is relatively genetically homogenous [20], in comparison with other populations. Therefore, patient care associated with type 2 DM in Oman may have unique and specific requirements, compared with those practiced in other populations.…”

Section: Introductionmentioning

confidence: 99%

Quality of Diabetes Care in Primary Health Centres in North Al-Batinah of Oman

Al-Shafaee¹,

Al-Farsi²,

Al-Kaabi³

et al. 2014

TOCMJ

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Objective: To assess the quality of diabetic care provided in primary health care settings in Oman.Methods: This was a cross-sectional study of randomly selected 500 patients with diabetes mellitus (DM) attending 6 primary care diabetic clinics in the north Al-Batinah region of Oman from January to December 2010. Nine standards on the quality of diabetes care were audited.Results: The mean age of the sample was 51±13 years, ranging from 15 to 87 years; the majority (61%) were females. The mean duration of DM was 4±3 years, ranging from 1 to 18 years. Seventy-seven percent of the patients attended diabetic clinics at least 4 times per year. Of the 9 assessed diabetic standards, HbA1c was documented in 33% of the patients, body mass index in 12%, low-density lipoprotein cholesterol (LDL-C) in 40%, urinary albumin:creatinine ratio in 28%, creatinine in 63% and blood pressure (BP) in 96%. Optimal control among the documented indicators was noted in 32, 21, 25, 85, 95 and 19%, respectively. Twenty percent of the patients had their ECGs done while only 39% of the patients had foot examination. No patient had attained control in all of HbA1c., BP and LDL-C.Conclusion: There is a gap between the recommended DM care guidelines and current practice with consequent poor quality of care in these patients.

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Triglyceride-mediated pathways and coronary heart disease

Cited by 8 publications

References 4 publications

The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol

The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol

A view on sphingolipids and disease

Quality of Diabetes Care in Primary Health Centres in North Al-Batinah of Oman

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