Triglyceride‐glucose index (<scp>TyG</scp> index) and endometrial carcinoma risk: A retrospective cohort study

Shi, Haimeng; Guo, Feifei; Zheng, Kewen; Li, Rong; Zhou, Huaijun

doi:10.1002/ijgo.15038

Cited by 4 publications

(3 citation statements)

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“…TyG index, measured based on blood fasting triglycerides and glucose, has been recommended as an effective surrogate marker for insulin resistance, and could integrate the effect of both triglycerides as well as glucose on endometriosis (19). Numerous studies have demonstrated the potential of the TyG index in predicting the risk of various metabolism-related disorders (11)(12)(13)(14)(15). However, the relationship between the TyG index and endometriosis has not been explored yet.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple epidemiological studies have demonstrated the association of TyG with a range of diseases, such as type 2 diabetes ( 11 ), cardiovascular disease ( 12 ), metabolic dysfunction-associated fatty liver disease ( 13 ) and gynecologic cancers ( 14 , 15 ). Given the potential involvement of metabolic disturbances in endometriosis pathogenesis, it is plausible to explore the association of insulin resistance with the risk of endometriosis.…”

Section: Introductionmentioning

confidence: 99%

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Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

Liu,

Wang,

et al. 2024

Front. Endocrinol.

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Background and AimsThe association of the triglyceride-glucose (TyG) index, a promising novel biomarker for insulin resistance, with the risk of endometriosis has not been investigated to date. This nationwide study aimed to explore the association between the TyG index and the endometriosis risk.MethodsData were obtained from the National Health and Nutrition Examination Survey (1999–2006). Female participants who provided complete data on the TyG index and endometriosis were enrolled in the analysis. Multivariate logistic regression analyses were utilized to assess the association of the TyG index with endometriosis, adjusted by multiple potential confounders. Meanwhile, in-depth subgroup analyses were conducted.ResultsA total of 1,590 eligible participants were included, among whom 135 (8.5%) women were diagnosed with endometriosis. The fully adjusted multivariate logistic model showed TyG index was significantly associated with the endometriosis risk (odds ratio [OR]Q4 versus Q1 2.04, 95% confidence interval [CI]: 1.15–3.62; P for trend=0.013). In subgroup analyses, the significantly positive association between TyG index and the risk of endometriosis was also found in parous women (ORQ4 versus Q1 2.18, 95% CI: 1.20–3.96), women without diabetes (OR Q4 versus Q1 2.12, 95% CI: 1.19–3.79), women who smoke currently (OR Q4 versus Q1 3.93, 95% CI: 1.33–11.58), women who drink currently (OR Q4 versus Q1 2.54, 95% CI: 1.27–5.07), and in women who use oral contraceptives (OR Q4 versus Q1 1.91, 95% CI: 1.04–3.51). Additionally, significantly increasing trends in the odds of endometriosis across the quartiles of the TyG index were observed in the above-mentioned subgroups (all P for trend<0.05).ConclusionsThis population-based study found that a higher TyG index, representing an increased level of insulin resistance, was associated with a higher risk of endometriosis among the US population. Our findings suggested TyG index might be a promising tool for the risk assessment of endometriosis. Prospective studies are warranted to further verify these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

Liu,

Wang,

et al. 2024

Front. Endocrinol.

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“…They also confirmed that the TyG index remained an independent risk factor for both AEH (OR 2.54, 95% CI 1.33-4.85, P = 0.005) and EC (OR 2.65, 95% CI 1.60-4.41, P < 0.001). In addition, a high TyG index showed a positive correlation with a more advanced pathological stage (OR 2.14, 95% CI 1.32-3.47, P = 0.002) and poorer tumour differentiation (OR 2.53, 95% CI 1.36-4.72, P = 0.004) [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Metabolic Factors in Endometrial Cancer: Evaluating the Utility of the Triglyceride-to-Glycemia Index and Triglyceride-to-High-Density Lipoprotein Ratio As Biomarkers

Marin,

Filipescu,

Vladareanu

et al. 2024

Cureus

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Introduction Endometrial cancer (EC) is the most common gynecological malignancy in developed countries worldwide. Its incidence is rising, making it a significant public health concern. The relationship between lipids, hyperglycemia, and anthropometric risk factors in the development of EC has gained increasing attention in recent years. Understanding the role of dyslipidemia as a part of metabolic syndrome is crucial for developing effective prevention and treatment strategies for EC. We investigate the association between dyslipidemia, hyperglycemia, and EC. This study aims to elucidate the potential contribution of altered lipid profiles and chronic hyperglycemia to endometrial carcinogenesis. By analyzing patients with benign and malignant endometrial pathologies, we seek to identify novel biomarkers and unravel the underlying mechanisms by which these metabolic factors influence the risk of developing EC. Material and methods Our retrospective unicentric study included 390 patients (192 diagnosed with EC and 198 with endometrial hyperplasia), in which we compared the clinical and biochemical characteristics, with a particular focus on lipid profiles and glycemic indices sampled 24-48 hours before surgery. The data obtained from the medical records were analyzed using statistical methods to compare selected metabolic factors between EC and endometrial hyperplasia. Results Our analysis revealed statistically significant differences in metabolic health and lipid profiles between patients diagnosed with EC and those with endometrial hyperplasia. The EC group exhibits trends towards higher levels of triglycerides (TG) and glycated hemoglobin, alongside a higher BMI. Notably, high-density lipoprotein cholesterol levels were lower in the EC group. Conclusion Although the triglycerides-to-fasting blood glucose index and the triglycerides-to-high-density lipoprotein cholesterol ratio did not demonstrate sufficient discriminatory power for predicting myometrial invasion depth in this study, further exploration of cost-effective emerging biomarkers warrants investigation in future studies.

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Evaluation of Triglyceride‐Glucose Index Elevation as a Biomarker and Risk Factor in Laryngeal Squamous Cell Carcinoma

Dogan,

Kucuk,

Tugrul

et al. 2024

Clinical Otolaryngology

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ObjectivesInsulin resistance is associated with increased levels of IGF‐1. IGF‐1 has been shown to increase the risk of laryngeal squamous cell carcinoma. The Triglyceride‐glucose index (TyG index) is a marker of insulin resistance. Our study aimed to investigate the relationship between the TyG index and laryngeal squamous cell carcinoma.DesignRetrospective cohort study.SettingTwo tertiary care academic hospitals.MethodsThe study included 53 patients with laryngeal squamous cell carcinoma (Group 1) and 48 healthy volunteers (Group 2). Laryngeal cancer patients were divided into two groups according to their stage. Stages I and II were named Group 1A, and Stages III and IV were called Group 1B. The TyG index was calculated as ln [fasting Triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The effect of the TyG index on laryngeal cancer was investigated on the parameters of sex, age, body mass index, and stage of the disease.ResultsThere were no significant differences in age, sex, and BMI between the groups. The TyG index of group 1 (4.75 ± 0.33) was significantly higher than that of group 2 (4.59 ± 0.15). The TyG index value of group 1B (4.84 ± 0.31) was significantly higher than both group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15). There was no significant difference between the TyG index values of group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15).ConclusionThe TyG index may be a promising laryngeal squamous cell carcinoma biomarker. People with a higher TyG index may have a higher incidence of laryngeal squamous cell carcinoma and a higher risk of progression.

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Triglyceride‐glucose index (TyG index) and endometrial carcinoma risk: A retrospective cohort study

Cited by 4 publications

References 24 publications

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

The Importance of Metabolic Factors in Endometrial Cancer: Evaluating the Utility of the Triglyceride-to-Glycemia Index and Triglyceride-to-High-Density Lipoprotein Ratio As Biomarkers

Evaluation of Triglyceride‐Glucose Index Elevation as a Biomarker and Risk Factor in Laryngeal Squamous Cell Carcinoma

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