Triglyceride-glucose index predicts independently type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies

Silva, Alessandra da; Caldas, Ana Paula Silva; Bressan, Josefina

doi:10.1016/j.pcd.2020.09.001

Cited by 79 publications

(57 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we compared the diagnostic values of the TyG index, FBG, and TG for arterial stiffness by receiver operating characteristics curve and the area under the curve, and found that TyG index had a better predictive value than FBG and TG alone (data not shown), which was consistent with previous studies [ 39 – 41 ]. With an increasing number of studies supporting the strong predictive value of TyG index for the development of CVDs and other chronic diseases such as type 2 diabetes [ 42 , 43 ], TyG index has been widely recognized as a simple and effective marker for disease prediction and prevention. A high TyG index could alert people to establish early lifestyle changes able to reduce the progression or incidence of disease.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

et al. 2021

Cardiovasc Diabetol

101

View full text Add to dashboard Cite

Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

et al. 2021

Cardiovasc Diabetol

101

View full text Add to dashboard Cite

show abstract

“…The TyG index is a non-insulin-based index that is inexpensive and could be easily obtained based on a single sample, which has been suggested as a reliable surrogate biochemical marker of insulin resistance (9). Accumulating evidence showed that higher TyG index is independently associated with and increased risk of type 2 diabetes mellitus in general population (10). However, previous studies evaluating the association between TyG and hypertension risk in community-derived adult population showed inconsistent results (11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis

Wang

Yang

Jiang

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Triglyceride-glucose (TyG) index is a recently proposed surrogate indicator of insulin resistance. Previous studies evaluating the association between TyG index and hypertension risk in general adult population showed inconsistent results. We performed a meta-analysis to systematically evaluate this association.Methods: Observational studies, which evaluated the independent association between TyG index and hypertension in the general adult population, were identified by systematic search of PubMed, Embase, Web of Science, Wanfang data, and Chinese National Knowledge Infrastructure databases. A random-effect model, which incorporated the potential intra-study heterogeneity, was used for the meta-analysis.Results: Eight observational studies including 200,044 participants were included. Results showed that compared with those with the lowest category of TyG index, subjects with the highest category of TyG index were associated with higher odds of hypertension [adjusted risk ratio (RR): 1.53, 95% confidence interval (CI): 1.26–1.85, I2 = 54%, P < 0.001]. Sensitivity analysis by excluding one dataset at a time showed consistent result (adjusted RR: 1.44–1.62, P all < 0.001). Results of univariate meta-regression analysis showed that differences in sample size, mean age, male proportion, mean body mass index, and study quality score among the included studies did not have significant influence on the association between TyG index and hypertension (P values all > 0.10), suggesting that differences in these characteristics may not be the major source of heterogeneity. Subgroup analyses showed that study characteristics such as study design, participant ethnicity, age, or sex of the participants did not significantly affect the association (P for subgroup difference all >0.05).Conclusions: Higher TyG index may be associated with higher odds of hypertension in general adult population. Large-scale prospective cohort studies are needed to validate these findings, and further studies are needed to elucidate the potential pathophysiological mechanisms underlying the association between TyG index and hypertension.

show abstract

“…The triglyceride and glucose index (TyG index), a product of triglyceride levels and fasting plasma glucose concentration, has recently been recognized as a useful clinical surrogate marker of insulin resistance [24,25] and systemic inflammation [26,27]. Moreover, the TyG index has been validated for predicting the risk of diabetes and cardiovascular disease syndrome [28][29][30][31][32], as well as for diagnosing metabolic syndrome [33]. However, to date there have been no studies of the relationship between the TyG index and sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008–2011 KNHANES

Ahn

Lee

2020

Lipids Health Dis

View full text Add to dashboard Cite

Background Since sarcopenia is an important risk factor for falls or cardiovascular disease, early detection and prevention of sarcopenia are being increasingly emphasized. Emerging evidence has indicated relationships between sarcopenia, insulin resistance, and inflammation. The triglyceride glucose (TyG) index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been shown to be associated with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults. Methods This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. A low skeletal muscle mass index (LSMI) was defined by the Foundation for the National Institutes of Health Sarcopenia Project criteria. A weighted multivariate logistic regression model was used to analyze relationships between TyG index tertiles and LSMI. Results The ORs (95% CIs) for LSMI in the second and third TyG tertiles, compared to the first tertile, were 1.463 (1.131–1.892) and 1.816 (1.394–2.366), respectively, after adjusting for confounding factors. Higher TyG index values were also associated with increased odds of LSMI in adults under 65 years who did not exercise regularly, who consumed less than 30 g of alcohol per day, who did not currently smoke, and who ate less than 1.5 g of protein/kg/day. Conclusion The TyG index was significantly and positively associated with LSMI in Korean adults.

show abstract

Triglyceride-glucose index predicts independently type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies

Cited by 79 publications

References 29 publications

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis

Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008–2011 KNHANES

Contact Info

Product

Resources

About