Triglyceride-Glucose Index is Significantly Associated with the Risk of Hyperuricemia in Patients with Nonalcoholic Fatty Liver Disease

Qi, Jiaxin; Ren, Xiaohu; Hou, Yan; Zhang, Yaqing; Zhang, Yanru; Tan, Eng Huat; Wang, Lihua

doi:10.2147/dmso.s408075

Cited by 7 publications

(6 citation statements)

References 60 publications

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“…Qi et al revealed that TyG index could be considered as a risk factor for developing hyperuricemia among patients in nonalcoholic fatty liver disease (NAFLD) [37].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride–glucose index and serum uric acid on the prediction of major adverse cardiovascular and cerebrovascular events after PCI: a retrospective cohort study

Huo,

Hu,

Zhang

et al. 2024

Preprint

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Background：Both serum uric acid (SUA) levels and TyG index have been reported to associate with adverse outcomes in patients with coronary artery disease. Limited evidence has focus on the combined and mediating effects of TyG on the association between SUA and cardiovascular and cerebrovascular events in patients underwent percutaneous coronary intervention (PCI). Methods：In this retrospective cohort study, a total of 6923 patients who underwent PCI were included. The patients were grouped based on the cut-off value of the TyG index and the sex-specifc criteria of hyperuricemia (HUA). The primary end point was major adverse cardiovascular and cerebrovascular events (MACCE), a composite of cardiac death, myocardial infarction, stroke, and target lesion revascularization. Cox regression analysis was conducted to estimate the association of TyG index and SUA with clinical outcome. A mediation analysis was performed to assess whether TyG index mediates the relationship between SUA and MACCE. Results：During a median of 693 days follow-up, 756 (10.9%) patients experienced MACCE. Compared with the Non-HUA/L-TyG group, the HUA/H-TyG group experienced the highest MACCE risk[hazard ratio(HR): 1.455,95% confidence interval(CI): 1.177–1.799, p < 0.001], followed by the HUA/L-TyG group(HR: 1.342, 95% CI: 1.093–1.647, p = 0.005) and Non-HUA/H-TyG (HR: 1.226, 95% CI: 1.007–1.493, p = 0.043). The TyG index significantly mediated 50.25% of the relationship between SUA and MACCE (p < 0.001). Conclusions：In patients undergone PCI, the TyG index and HUA synergically increased the risk of cardiovascular and cerebrovascular events, and TyG index partially mediated the association between HUA and clinical outcomes, which emphasizes that combining TyG and SUA can help identify high risk patients.

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“…Qi et al revealed that TyG index could be considered as a risk factor for developing hyperuricemia among patients in nonalcoholic fatty liver disease (NAFLD) [37].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride–glucose index and serum uric acid on the prediction of major adverse cardiovascular and cerebrovascular events after PCI: a retrospective cohort study

Huo,

Hu,

Zhang

et al. 2024

Preprint

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“…[6][7][8]. Several studies have reported an association between the TyG index and hyperuricemia [9][10][11] suggesting that the TyG index may also be related to gout.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the triglyceride–glucose index, blood uric acid levels, and prevalence of gout in Korean adults: Eighth Korean National Health and Nutrition Examination Survey (2019–2021)

Ahn,

Kim,

Hur

et al. 2024

Preprint

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Background: The triglyceride and glucose (TyG) index is a useful marker of insulin resistance and metabolic syndrome. Several studies have reported a link between this index and serum uric acid levels. However, few studies have shown a concrete association between the TyG index, uric acid levels, and prevalence of gout. The objective of this study was to investigate the correlation between this index and uric acid levels, as well as their potential associations with the incidence of gout. Methods: Data derived from the Eighth Korea National Health and Nutrition Examination Survey conducted from 2019 to 2021 were used. The study population included adults >19 years of age andconsisted of 16,340 participants who were subjected to blood tests to measure their fasting blood glucose and triglyceride levels. Additionally, the participants responded to a questionnaire regarding the diagnosis of gout, making them eligible for inclusion in the study. The TyG index was categorized into quartiles. Results: Of the 16,340 total subjects, 321(2.1 %) were diagnosed with gout. After an adjustment for age and metabolic parameters, the TyG index was positively related to serum uric acid levels (β = 0.247, p < 0.001). Compared to the risk in the lowest quartile group, as a reference, the adjusted odd ratio, with a 95 % confidence interval, for the incidence of gout was 2.002 (1.157–3.465) in the highest quartile group. Conclusion: An elevated TyG index is associated with increased blood uric acid levels, and the TyG index is also associated with the prevalence of gout.

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“…Several epidemiological studies have investigated the association between the TyG index and hyperuricemia in different populations. A retrospective case-control study found that the TyG index was an independent risk factor for hyperuricemia in patients with non-alcoholic fatty liver disease (NAFLD) (OR[95 %CI]:2.00[1.38,2.91]) ( Qi et al, 2023 ). In addition, in a longitudinal study, the TyG index was also positively correlated in diabetic kidney disease (DKD) adults [15].…”

Section: Introductionmentioning

confidence: 99%

A national study exploring the association between triglyceride-glucose index and risk of hyperuricemia events in adults with hypertension

Wang,

Chao,

Zhang

et al. 2024

Preventive Medicine Reports

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Triglyceride-Glucose Index is Significantly Associated with the Risk of Hyperuricemia in Patients with Nonalcoholic Fatty Liver Disease

Cited by 7 publications

References 60 publications

Triglyceride–glucose index and serum uric acid on the prediction of major adverse cardiovascular and cerebrovascular events after PCI: a retrospective cohort study

Triglyceride–glucose index and serum uric acid on the prediction of major adverse cardiovascular and cerebrovascular events after PCI: a retrospective cohort study

Relationship between the triglyceride–glucose index, blood uric acid levels, and prevalence of gout in Korean adults: Eighth Korean National Health and Nutrition Examination Survey (2019–2021)

A national study exploring the association between triglyceride-glucose index and risk of hyperuricemia events in adults with hypertension

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