Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China

Abstract

BackgroundHyperuricemia (HUA) is a metabolic anomaly with an increased incidence rate, causing a global medical burden. Several studies have confirmed that obesity and insulin resistance (IR) are the risk factors for HUA. Reports on the predictive power of different obesity indices for HUA are limited. This study aimed to compare the association between different general, abdominal, and visceral obesity indices and markers of the IR-triglyceride glucose (TyG) index with serum uric acid (SUA) and to assess the ability of these indices to predict HUA.MethodsA total of 2243 participants were recruited from Barkol County Hospital and surrounding township hospitals in Xinjiang. Obesity indices, including the atherogenic index of plasma, cardiometabolic index, visceral adiposity index, lipid accumulation product index, a body shape index, body roundness index, waist circumference, waist-to-height ratio, body mass index, and TyG index, were divided into four quartiles. Moreover, partial correlations and logistic regression were used to analyze the association between these indices and SUA. The area under the curve (AUC) and receiver operating characteristic curves were used to analyze the predictive value of these indices for HUA.ResultsAfter controlling for confounding variables, the association between the TyG index and HUA was stronger than that between the obesity indices in both males and females. The odds ratios (ORs) for HUA in the highest quartile of the TyG index were 2.098 (95% confidence interval, 1.555–2.831) in males and 7.788 (95% CI, 3.581–16.937) in females. For males, the AIP, CMI, VAI, LAP index, and TyG index were able to discriminate HUA, and the TyG index showed the highest AUC value of 0.586 (95% CI, 0.557–0.614; P < 0.001). For females, all indices, except BMI, can discriminate HUA. Moreover, the visceral obesity index CMI showed the highest AUC value of 0.737 (95% CI, 0.691–0.782; P < 0.001). Meanwhile, the TyG index had a relatively high AUC value of 0.728 (95% CI, 0.682–0.773; P < 0.001).ConclusionThe TyG index was significantly related to HUA and was superior to obesity indices in identifying HUA in the medical checkup population in Xinjiang, China.

Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease

“…Shi et al 21 performed cross-sectional studies on 6,466 subjects and revealed that TyG was positively related to hyperuricemia after adjusting for potential confounding factors. Kahaer et al 22 performed a cross-sectional analysis on 2,243 patients in a medical check-up population from Xinjiang, China, and the results revealed that the TyG index was more closely associate with hyperuricemia than obesity indices. Yu et al 23 performed a cross-sectional study on adults with hypertension, and showed that a higher level of TyG was associated with a higher risk of hyperuricemia.…”

“…Studies have shown that insulin resistance is a pathophysiological process that is closely associated with hyperuricemia 17 ,and hyperinsulinemia caused by insulin resistance can cause renal urate excretion reduce, resulting in blood urate accumulation 18 . Recent studies have revealed the correlation between TyG index and hyperuricemia, and the correlation was stronger than that between obesity indices and hyperuricemia among general Chinese populations 19 – 22 . In addition, in a cross-sectional study, the TyG index and hyperuricemia were also positively correlated in hypertensive adults 23 .…”

Association of obesity, triglyceride-glucose and its derivatives index with risk of hyperuricemia among college students in Qingdao, China

“…2.2 According to the definition from “Guidelines for Diagnosis and Treatment of Hyperuricemia and Gout in China (2019)”, two measurements on different days, UA > 420 μmol/l is considered hyperuricemia ( 13 ). Therefore, based on the previous studies ( 12 , 14 ), it was calculated using the following formula:…”

“…Although obesity indicators and insulin resistance index can predict the risk of HUA ( 11 , 12 ), the more suitable indicator for predicting the risk of HUA in Chinese college students has yet to be concluded. Therefore, this study used a cross-sectional survey to analyze and compare the three indices of visceral adiposity (LAP index, ABSI, and BRI), general adiposity index (BMI), abdominal adiposity index (WC and WHtR), with the TyG index and its derivatives to predict the risk of HUA.…”

Triglyceride-Glucose Index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease

“…Studies have shown that the pathophysiological process of insulin resistance is closely associated with hyperuricemia 17 and hyperinsulinemia caused by insulin resistance, can cause renal urate excretion to be reduced, resulting in blood urate accumulation 18 . Recent studies have revealed the correlation between TyG index and hyperuricemia, and the correlation was more closely than that between obesity indices and hyperuricemia among general Chinese populations [19][20][21][22] . In addition, in a cross-sectional study, the TyG index and hyperuricemia were also positively correlated in hypertensive adults 23 .…”