Triglyceride-glucose index is associated with quantitative flow ratio in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention

Abstract

BackgroundThe triglyceride-glucose (TyG) index is a novel marker representing the degree of insulin resistance (IR) and is closely related to cardiovascular diseases. However, the association between the TyG index and vascular function in patients with acute ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) remains unknown.Materials and methodsThis study was a post hoc analysis of a multicenter, prospective cohort study. In this study, patients with STEMI who underwent PCI were included, and coronary angiography data were analyzed by Quantitative coronary angiography (QCA) and quantitative flow ratio (QFR). In addition, the TyG index was calculated as follows: Ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl) × 1/2]. According to the post-PCI QFR, patients were divided into two groups: post-PCI QFR ≤ 0.92 group and post-PCI QFR > 0.92 group. Construction of logistic regression model to explore the relationship between the TyG index and post-PCI QFR.ResultsA total of 241 STEMI patients were included in this study. Compared with patients in the post-PCI QFR > 0.92 group, the TyG index was higher in the post-PCI QFR ≤ 0.92 group. Logistic regression model showed that after adjusting for other confounding factors, the TyG index was positively correlated with the risk of post-PCI QFR ≤ 0.92 (OR = 1.697, 95% CI 1.171–2.460, P = 0.005). Restricted cubic splines showed the cutoff value of TyG index associated with post-PCI QFR ≤ 0.92 risk was 9.75.ConclusionThe TyG index was associated with the risk of post-PCI QFR ≤ 0.92 in STEMI patients. The risk of post-PCI QFR ≤ 0.92 increased when the TyG index exceeded 9.75.

Baseline TyG index, myoglobin, and cerebral infarction history predict the onset of pulmonary hypertension in coronary artery disease patients after PCI treatment within a median of 4.5 years: a prospective cohort study

“…Though PH has attracted an increasing amount of attention from clinical physicians and researchers, PH’s clinical characteristics and risk factors in CAD patients who have received PCI treatment have not been widely investigated (19,20,24,25,40). The roles of the TyG index in outcomes of patients who underwent PCI treatment have been partly reported (7,10,41,42). The associations between TyG index and poor prognosis in patients with acute ST-elevation myocardial infarction after PCI have also been indicated in previous studies(7,10).…”

“…The roles of the TyG index in outcomes of patients who underwent PCI treatment have been partly reported (7,10,41,42). The associations between TyG index and poor prognosis in patients with acute ST-elevation myocardial infarction after PCI have also been indicated in previous studies(7,10). However, the potential role of the TyG index as a predictor of PH in CAD patients after PCI treatment has not been studied.…”

“…Among ST elevation myocardial infarction patients, the higher TyG index has been indicated to increase the risk of major adverse cardiac and cerebrovascular events(7,10,11). Although a number of the previous studies have indicated the associations between TyG index and vascular diseases, no studies further identify the predictive role of the TyG index in pulmonary hypertension (PH) among coronary artery disease (CAD) patients after PCI treatment (9,12-14).…”

Índice de Triglicerídeos-Glicose e Fluxo Lento Coronariano: Uma Nova Ferramenta Diagnóstica?

“…More and more studies have found that the TyGI is not only significantly associated with the risk of atherosclerosis, DM, and coronary artery disease, but its elevated levels increase the poor prognosis of CVDs such as in-stent restenosis and atrial fibrillation. 3 The investigation of the relationship between TyGI and coronary slow flow (CSF) could be of great interest in clinical practice, as studies have demonstrated a strong association between IR and CSF, considering IR as an independent risk factor for CSF in patients with IGT. 4,5 Arterial stiffness is one of the earliest types of functional damage that occurs during the vascular aging process, during which arterial elasticity decreases.…”

“…Furthermore, there is a positive correlation with poor prognosis in patients with acute myocardial infarction when its level exceeds 9.75, which may serve as a threshold for assessing residual coronary ischemia. 3 The TyGI level above 9.75 increased the risk of postpercutaneous coronary intervention quantitative flow ratio ≤ 0.92, which has a poor prognosis. Therefore, TyGI above 9.75 may be used as a threshold for intensive drug therapy to improve coronary ischemia after percutaneous coronary intervention.…”