Triglyceride glucose index exacerbates the risk of future cardiovascular disease due to diabetes: evidence from the China Health and Retirement Longitudinal Survey (CHARLS)

Ye, Zixiang; Xie, Enmin; Jiao, Siqi; Gao, Yanxiang; Li, Peizhao; Tu, Yimin; Guo, Ziyu; Li, Qing; Wu, Yaxin; Yu, Xiaozhai; Li, Yike; Yu, Chenghao; Ren, Jingyi; Zheng, Jingang

doi:10.1186/s12872-022-02673-y

Cited by 10 publications

(7 citation statements)

References 38 publications

(35 reference statements)

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“…The current study explores the relationship between the TyG index and the risk of developing cardiovascular disease in the Chinese middle-aged and elderly population in a large-scale prospective cohort study from the China health and retirement longitudinal study (CHARLS). This study is a follow-up of our previous study from the same cohort, which demonstrated that the elevated TyG index strengthens the association between diabetes and cardiovascular disease [11].…”

Section: Introductionsupporting

confidence: 64%

The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults

Xie

Gao

et al. 2022

BMC Endocr Disord

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Objective We aimed to investigate the association between triglyceride glucose index and cardiovascular disease (CVD) development in the Chinese middle-aged and elderly population using the China Health and Retirement Longitudinal Study dataset 2011–2018. Methods Basic characteristics of participants, including sociodemographic information, and health conditions, were acquired. Logistic regression analyses and restricted cubic spline regression analyses were conducted to investigate the association between the triglyceride glucose index and future CVD risks. Subgroup analyses were performed to evaluate potential interaction. Results Seven hundred fifty-three of 6114 (12.3%) participants have developed CVD in 2018 over an approximately 7-year follow-up. The logistic regression analysis exhibited that compared to the lowest triglyceride glucose index group, the multivariable OR for future CVD was 0.985 (95%CI 0.811–1.198) in the T2 triglyceride glucose index group and 1.288 (95%CI 1.068–1.555) in the T3 TyG index (P for trend 0.006). The restricted cubic spline regression analysis showed the nonlinear association between triglyceride glucose index and CVD incidence; the cut-off values were 8.07 and 8.57, respectively, after total adjustment. Gender, fast blood glucose, and triglycerides interacted with triglyceride glucose index and CVD except for BMI. Conclusion The triglyceride glucose index was nonlinearly related to the risk of future cardiovascular disease in the middle-aged and elderly Chinese population.

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Section: Introductionsupporting

confidence: 64%

The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults

Xie

Gao

et al. 2022

BMC Endocr Disord

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“… 12 In addition, the study discovered that high TyG index level could increase the risk of CVD in DM patients. 9 The report indicated that the prevalence of CVD caused by the high level of the TyG index was 1.25-fold that of the low TyG index level. 27 Similarly, our study discovered that the TyG index was an independent hazard factor for new-onset hypertension.…”

Section: Discussionmentioning

confidence: 99%

“… 7 Furthermore, the TyG index has been confirmed to be a marker of insulin resistance (IR). 8 However, recent studies confirmed that the TyG index could increase cardiovascular disease hazard and result in atherosclerosis and arterial stiffness, 9–12 which might be linked to IR. 13–15 Moreover, among the many risk factors of hypertension, atherosclerosis and arterial stiffness play a significant role in hypertension development, 16–18 and their ability to contribute to development of hypertension may increase with age-related physiological alterations.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose Index Increases Significantly Risk of Hypertension Development in Chinese Individuals Aged ≥45 Years Old: Analysis from the China Health and Retirement Longitudinal Study

Liu

Xuan

Yin

et al. 2023

JMDH

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Objective Our purpose was to explore the relationship between triglyceride glucose (TyG) index and the risk of new-onset hypertension in Chinese individuals aged ≥45 years. Methods From 2011 to 2018, data from the China Health and Retirement Longitudinal Survey (CHARLS) were analyzed. The relationship between TyG index and hypertension was assessed utilizing Cox regression and restricted cubic spline (RCS) plot, and the importance of the TyG index in hypertension development was demonstrated by a random forest machine learning model. Finally, subgroup analysis was conducted to test for potential interactions on hypertension development between the TyG index and subgroups. Results 19.7% of the 4755 individuals who were involved in this survey developed hypertension over an average follow-up period of 5.22 years. Compared with the first quartile of albumin, the multivariate HR (95% CI) for the risk of new-onset hypertension across the TyG index quartiles was 1.09 (0.89, 1.33), 1.09 (0.89, 1.33), and 1.29 (1.06, 1.58), respectively ( P for trend <0.001). The RCS plot revealed a linear relationship ( P for nonlinear = 0.322), and the random forest machine learning model illustrated that the TyG index was a significant hazard factor on hypertension development. There was no interaction between subgroups and the relationships of the TyG index with the prevalence of hypertension (all P -value >0.05). Conclusion TyG index was an independent hazard indicator for new-onset hypertension, and routine measurement and control of TyG index level might be great for preventing hypertension development.

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“…Similarly, Hong et al suggested its potential in early cardiovascular event detection for those aged 40 and older [ 34 ]. Research on Chinese middle-aged and elderly diabetic patients revealed an elevated TyG index associated with an increased CVD risk [ 35 ]. Moreover, a study of individuals over 65 exhibited a robust correlation between the TyG index and all-cause/CVD mortality [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

Liu,

Liang

2024

Cardiovasc Diabetol

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Background The relationship between the triglyceride–glucose (TyG) index and the risk of cardiovascular disease (CVD) in the U.S. population under 65 years of age with diabetes or prediabetes is unknown. The purpose of this study was to investigate the relationship between baseline TyG index and CVD risk in U.S. patients under 65 years of age with diabetes or prediabetes. Methods We used data from the 2003–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate regression analysis models were constructed to explore the relationship between baseline TyG index and CVD risk. Nonlinear correlations were explored using restricted cubic splines. Subgroup analysis and interaction tests were also conducted. Results The study enrolled a total of 4340 participants with diabetes or pre-diabetes, with a mean TyG index of 9.02 ± 0.02. The overall average prevalence of CVD was 10.38%. Participants in the higher TyG quartiles showed high rates of CVD (Quartile 1: 7.35%; Quartile 2: 10.04%; Quartile 3: 10.71%; Quartile 4: 13.65%). For CVD, a possible association between the TyG index and the risk of CVD was observed. Our findings suggested a linear association between the TyG index and the risk of CVD. The results revealed a U-shaped relationship between the TyG index and both the risk of CVD (P nonlinear = 0.02583) and CHF (P nonlinear = 0.0208) in individuals with diabetes. Subgroup analysis and the interaction term indicated that there was no significant difference among different stratifications. Our study also revealed a positive association between the TyG index and comorbid MetS in the U.S. population under 65 years of age with prediabetes or diabetes. Conclusions A higher TyG index was linked to an increased likelihood of CVD in the U.S. population aged ≤ 65 years with prediabetes and diabetes. Besides, TyG index assessment will contribute to more convenient and effective screening of high-risk individuals in patients with MetS. Future studies should explore whether interventions targeting the TyG index may improve clinical outcomes in these patients.

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Triglyceride glucose index exacerbates the risk of future cardiovascular disease due to diabetes: evidence from the China Health and Retirement Longitudinal Survey (CHARLS)

Cited by 10 publications

References 38 publications

The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults

The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults

Triglyceride Glucose Index Increases Significantly Risk of Hypertension Development in Chinese Individuals Aged ≥45 Years Old: Analysis from the China Health and Retirement Longitudinal Study

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

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