Triglyceride concentrations in primary gout and gout of chronic lead nephropathy

Abnormal Renal Urate Homeostasis in Systemic Disorders

“…Recent studies have shown the most common lipid abnormality to be hypertriglyceridaemia [6,10,13,44], rather than hypercholesterolaemia, as first suggested. This greater incidence of hypertriglyceridaemia in patients with primary gout was not explicable by the associated obesity or by alcohol consumption [42], and the triglyceride increases were usually associated with increases in both phospholipid and free fatty acid concentrations [26], One explanation for this association of hypertriglyceridaemia with hyper uricaemia is that, while the disorder of lipid metabolism may be the primary disorder, the associated hyperuricaemia, presenting as gouty arthritis, induces the first symptom in the patient. In such a case, the hyperlipoproteinaemia remains unrecognized until sought specifically [3], An alternative explanation of the association of hyperuricaemia and hypertriglyceridaemia might be that they are both secondary to another abnormality.…”

“…The development of gout has frequently been associated with obesity and a group of patients with primary gout was found to average 20% above the desirable weight for height [42]. Recent studies have also confirmed a positive correlation between the serum urate concentration and body weight, both in Caucasians [59,67,75] and in Polynesians, recognized as a group with a tendency towards hyperuricaemia [43].…”

Abnormal regulation of carbohydrate metabolism in primary gout.

“…The mean triglyceride value in the present study agrees with the mean level of 174 mg/100 ml reported recently (Wiedemann and others, 1972). Other investigators have found no correlation in gouty patients between hypertriglyceridaemia and renal disease, obesity, or alcoholism (Emmerson and Knowles, 1971). In the present study, hypertriglyceridaemia was not explained by obesity or impaired glucose tolerance.…”

Food, drink, and gout.

“…For example, in a British study of 354 patients with gout 480°,, were more than 1500 over their ideal body weights,10 and comparable findings have been reported from other countries including Denmark,"1 the United States,12 and Australia. 13 The relation appears to be one of cause and effect, since loss of weight lowers the serum urate concentration.14 ' Its exact nature is poorly understood but has recently been reviewed, together with the further difficult interrelation with hyperlipidaemia and impaired glucose tolerance. 16 Finally, the part played by alcohol must be considered, in the light of A B Garrod's opinion over 100 years ago that "fermented liquors" are a powerful predisposing cause of gout.…”