Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease

Hossain, Sania; Sultana, Sadia; Zaman, Khan Md. Shahariar; Shafiq, Sabrina; Rahman, A. K. M. Shahidur; Hossain, Shakhawate; Islam, Saiful; Uddin, Mahammod Selim; Faroque, Md. Omar; Ferdoushi, Sheuly; Paul, Debatosh; Rahman, Md. Quddusur

doi:10.4236/jbm.2020.811012

Cited by 5 publications

(7 citation statements)

References 24 publications

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“…However, the cut points for females with elevated ALT in our case were 35 U/L. Another study from Bangladesh determined a similar cutoff value of 8.85 (sensitivity 93.5% and specificity 79% to predict NAFLD), and research from China found a similar cutoff value of 8.5 (sensitivity 72.2% and specificity 70.5%) [ 27 , 28 ]. The present study indicated an association between a high TyG index and elevated aminotransferase.…”

Section: Discussionsupporting

confidence: 52%

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

et al. 2023

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Background Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationship between the TyG index and aminotransferase. Methods A serial cross-sectional study was conducted among 232,235 Royal Thai Army (RTA) personnel aged 35–60 years from 2017–2021. Elevated aminotransferase was defined as ≥ 40 U/L and ≥ 35 U/L among males and females, respectively. A linear regression analysis between the TyG index and log-transformed aminotransferase was performed. High- and low-TyG index groups were divided according to Youden’s index cut point for predicting elevated aminotransferase. Multivariable logistic analysis was also utilized to investigate the association between the TyG index and elevated aminotransferase. Results The TyG index revealed a dose‒response relationship with log-transformed aminotransferase in both sexes and all age groups. The TyG index was positively associated with the prevalence of elevated aminotransferases. In comparison with the first TyG quartile (< 8.37), participants in the fourth quartile (> 9.23) had a higher chance for elevated ALT (AOR: 2.81, 95% CI: 2.71–2.90 for males and AOR: 4.01, 95% CI: 3.50–4.60 for females, P < 0.001 for both). In the fourth TyG quartile, the prevalence of elevated ALT was 47.8% and 40.2% in the participants aged 35–44 and male participants, respectively. Conclusion A high TyG index is a novel risk factor for elevated aminotransferase among RTA personnel. Those with a high TyG index should be screened for elevated aminotransferase, particularly males aged 35–44 years.

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Section: Discussionsupporting

confidence: 52%

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

et al. 2023

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“…However, when interpreting the results of our study, it must be taken into consideration that all the patients enrolled in the study were diagnosed with metabolic syndrome, a disorder that is associated with IR and an increased TyG index. Furthermore, the lack of correlation between our results and the data reported in the medical literature, associating TyG with both the presence and the severity of liver steatosis [ 22 ], can be explained by different diagnostic methods, as most of the published studies assessed liver steatosis using non-invasive methods, while the diagnosis of liver steatosis in our study was established after liver biopsy and histopathological examination.…”

Section: Discussionmentioning

confidence: 59%

“…The TyG index, which uses regular blood tests (FPG, serum triglycerides) is a non-invasive marker of IR as well as a good predictor for NAFLD [ 20 , 21 ]. Studies showed an association of liver steatosis with TyG values above 8.5–8.85 [ 5 , 6 , 22 , 23 ]. The mean TyG value reported in our study is 8.93 ± 1.45, with no statistically significant difference between subjects that presented liver steatosis and the ones that did not present this type of liver disorder.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome

Amzolini

Forțofoiu

Alhija

et al. 2022

JCM

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Background: Nonalcoholic fatty liver disease (NAFLD) is regarded as a component of metabolic syndrome, which involves insulin resistance (IR) as the primary physiopathological event. The aim of this study was to establish the association between IR, assessed using the triglyceride and glucose index (TyG), and histopathological features of NAFLD lesions. Methods: The study included 113 patients with metabolic syndrome. Fasting plasma glucose (FPG), fasting lipid profiles and liver enzymes were measured. IR was assessed by the TyG index. Liver biopsy was performed for assessment steatosis and fibrosis. Results: the TyG index had a mean value of 8.93 ± 1.45, with a higher value in the patients with overweight (p = 0.002) and obesity (p = 0.004) characteristics than in the patients with normal weight. The TyG index mean value was 8.78 ± 0.65 in subjects without NASH, 8.91 ± 0.57 in patients with borderline NASH and 9.13 ± 0.55 in patients with definite NASH. A significant difference was found between subjects without NASH and the ones with definite NASH (p = 0.004), as well as in patients with early fibrosis vs. those with significant fibrosis. The analysis of the area under the ROC curve proved that the TyG index is a predictor of NASH (p = 0.043). Conclusion: the TyG index is a facile tool that can be used to identify individuals at risk for NAFLD.

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“…However, when interpreting the results of our study, it must be taken into consideration the fact that all the patients enrolled in the study were diagnosed with metabolic syndrome, disorder that is associated with IR and an increased TyG index. Furthermore, the lack of correlation between our results and the data reported in the medical literature, associating TyG with both the presence and the severity of liver steatosis [22], can be explained by different diagnostic method, as most of the published studies assessed liver steatosis using non-invasive methods, while the diagnosis of liver steatosis in our study was established after liver biopsy and histopathological examination.…”

Section: Figure 10 the Study Of Tyg Index In Relationship With Nash Categoriesmentioning

confidence: 50%

“…TyG index, which uses regular blood tests (FPG, serum triglycerides), is a non-invasive marker of IR as well as a good predictor for NAFLD [20,21]. Studies showed an association of liver steatosis with TyG values above 8.5-8.85 [5,6,22,24]. The mean TyG value reported in our study is 8.93 ± 1.45, with no statistic significant difference between subjects that presented liver steatosis and the ones that did not present this type of liver disorder.…”

Section: Figure 10 the Study Of Tyg Index In Relationship With Nash Categoriesmentioning

confidence: 99%

Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome

Amzolini¹,

Forțofoiu²,

Al-Hija³

et al. 2021

Preprint

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Background: Nonalcoholic fatty liver disease (NAFLD) is regarded as a component of metabolic syndrome, which has insulin resistance (IR) as the primary physiopathological event. The aim of study was to establish the association between IR, assessed using triglyceride and glucose index (TyG), and histopathological features of NAFLD lesions. Methods: The study included patients with metabolic syndrome. Fasting plasma glucose (FPG), fasting lipid profiles and liver enzymes were measured. IR was assessed by TyG index. Liver biopsy was performed for assessment steatosis and fibrosis. Results: TyG index had a mean value of 8.93 ± 1.45, with a higher value in the patients with overweight (p=0.002) and obesity (p=0.004) than in the patients with normal weight. TyG index mean value of 8.78 ± 0.65 in subjects without NASH, 8.91 ± 0.57 in patients with borderline NASH and 9.13 ± 0.55 in patients with definite NASH. Significant difference was found between subjects without NASH and the ones with definite NASH (p=0.004). The analysis of the area under the ROC curve proved that TyG index is a predictor for NASH (p=0.043). Conclusion: TyG index is a facile tool used to identify individuals at risk for NAFLD, but not for the progression of liver lesions.

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Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease

Cited by 5 publications

References 24 publications

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome

Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome

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