Triggering the Electrolyte-Gated Organic Field-Effect Transistor output characteristics through gate functionalization using diazonium chemistry: Application to biodetection of 2,4-dichlorophenoxyacetic acid

Nguyen, Thom Thi; Nguyen, Thuc‐Quyen; Anquetin, Guillaume; Reisberg, S.; Noël, Vincent; Mattana, Giorgio; Touzeau, Jérémy; Barbault, Florent; Pham, Minh‐Chau; Piro, Benoı̂t

doi:10.1016/j.bios.2018.04.051

Cited by 36 publications

(30 citation statements)

References 36 publications

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“…7 a Competitive immunodetection at the semiconductor/electrolyte interface of the BPA-EGOFET, and the symbol, formula, and description of BPA-EGOFET (reprinted from [43] with permission from Elsevier). b Schematic illustration of the gate-modified EGO-FET, before (left) and after (right) addition of the target molecule 2,4-D in the electrolyte (reprinted from [44] with permission from Elsevier) receptor layer tended to aggregate extensively, which limited the range of MBP accessibility and binding. PS-MA had the highest intensity and the largest amount of immobilized Abs.…”

Section: Immobilization Strategies Of Proteins By Receptor Layermentioning

confidence: 99%

“…By the use of low-molecular-weight receptors such as aptamers, the binding reaction can be restricted to the electrical double layer to avoid the unresponsiveness problem associated with the Debye length effect. To overcome the restrictions of molecular weight and Debye length of the receptor, Nguyen et al [44] synthesized 2,4-dichlorophenoxyacetic acid (2,4-D) derivative molecular probes by electro-grafting diazo salt to functionalize the gate electrode. Fig.…”

Section: Immobilization Strategies Of Aptamers and Other Moleculesmentioning

confidence: 99%

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Recent Advances in Immobilization Strategies for Biomolecules in Sensors Using Organic Field-Effect Transistors

Wang

Xiao

et al. 2020

Trans. Tianjin Univ.

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Organic field-effect transistors (OFETs) are fabricated using organic semiconductors (OSCs) as the active layer in the form of thin films. Due to its advantages of high sensitivity, low cost, compact integration, flexibility, and printability, OFETs have been used extensively in the sensing area. For analysis platforms, the construction of sensing layers is a key element for their efficient detection capability. The strategy used to immobilize biomolecules in these devices is especially important for ensuring that the sensing functions of the OFET are effective. Generally, analysis platforms are developed by modifying the gate/electrolyte or OSC/electrolyte interface using biomolecules, such as enzymes, antibodies, or deoxyribonucleic acid (DNA) to ensure high selectivity. To provide better or more convenient biological immobilization methods for researchers in this field and thereby improve detection sensitivity, this review summarizes recent developments in the immobilization strategies used for biological macromolecules in OFETs, including cross-linking, physical adsorption, embedding, and chemical covalent binding. The influences of biomolecules on device performance are also discussed.

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Section: Immobilization Strategies Of Proteins By Receptor Layermentioning

confidence: 99%

Section: Immobilization Strategies Of Aptamers and Other Moleculesmentioning

confidence: 99%

Recent Advances in Immobilization Strategies for Biomolecules in Sensors Using Organic Field-Effect Transistors

Wang

Xiao

et al. 2020

Trans. Tianjin Univ.

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“…By properly functionalizing the gate electrode with specific molecules (e.g., antibodies), the target molecules present inside the electrolyte interact with the gate surface, leading to modification of the interface capacitance which, in turn, modulates the drain current, even for an uncharged target at trace levels [ 91 ]. Their pertinence has been demonstrated for pH sensing [ 92 , 93 ] and biosensing for the detection of small toxic organic molecules [ 91 , 94 ] or proteins secreted by cells (e.g., interleukins [ 95 , 96 ] and TNF-α (tumor necrosis factor alpha) [ 97 ]). The fact that EGOFETs have not yet been used for living cells’ monitoring could be due to the fact that these EGOFETs have always been reported using top-gate configurations, and never using side-gates.…”

Section: Devicesmentioning

confidence: 99%

Transistors for Chemical Monitoring of Living Cells

2018

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Featured Application Animal testing will be soon replaced by better accepted and less expensive in-vitro cell culture models, which explains the recent demand for real-time cell culture monitoring systems. They can bring high throughput screening and could be used not only for biomedical purposes (drug discovery, toxicology, protein expression, cancer diagnostic, etc.), but also for environmental ones (qualification of pollutants cocktails, for example). Beyond this, in-situ monitoring also participates in strengthening the fundamental knowledge about cells metabolism. AbstractWe review here the chemical sensors for pH, glucose, lactate, and neurotransmitters, such as acetylcholine or glutamate, made of organic thin-film transistors (OTFTs), including organic electrochemical transistors (OECTs) and electrolyte-gated OFETs (EGOFETs), for the monitoring of cell activity. First, the various chemicals that are produced by living cells and are susceptible to be sensed in-situ in a cell culture medium are reviewed. Then, we discuss the various materials used to make the substrate onto which cells can be grown, as well as the materials used for making the transistors. The main part of this review discusses the up-to-date transistor architectures that have been described for cell monitoring to date.

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“…This subtype of organic transistors is called electrolyte-gated organic field effect transistors (EGOFET) in which the organic semiconducting channel is capacitively coupled with the gate electrode by means of an electrolytic solution [7]. Examples of OSC recently reported in the literature include poly(N-alkyldiketopyrrolopyrroledithienylthieno[3,2-b] thiophene) [8], poly-3hexylthiophene (P3HT) [9], poly(2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene) [10], pentacene [11].…”

Section: Introductionmentioning

confidence: 99%

A Review of Carbon Nanotubes Field Effect-Based Biosensors

et al. 2020

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Field effect-based biosensors (BioFETs) stand out among other biosensing technologies due to their unique features such as real time screening, ultrasensitive detection, low cost, and amenability to extreme device miniaturization due to the convenient utilization of nanoscale materials. Nanodevices pave the way for the detection of tiny biomolecules and minute concentrations of analytes as they are ultrasensitive to surface charge modulation, allowing for better point-of-care screening of various life-threatening infectious diseases. Semiconducting carbon nanotubes (sc-CNTs) are exceptionally promising for FET-channel integration to replace bulky silicon technology beyond the dimensions of the short channel effects for their 1D ultrathin structure, superior electronic features, and biocompatibility. However, performance of CNTFET biosensors is influenced by the inhomogeneous interface between sc-CNTs and metallic source and drain electrodes. This article reviews recent studies on CNTFET biosensors, morphology of these devices and the cause-and-effect of the interface issues between sc-CNTs and metallic electrodes. Finally, future outlook on suggested technology to improve the performance of such CNTFET devices is presented. INDEX TERMS BioFETs, biomolecules, biosensors, carbon nanotubes, contact resistance, metal electrodes.

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Triggering the Electrolyte-Gated Organic Field-Effect Transistor output characteristics through gate functionalization using diazonium chemistry: Application to biodetection of 2,4-dichlorophenoxyacetic acid

Cited by 36 publications

References 36 publications

Recent Advances in Immobilization Strategies for Biomolecules in Sensors Using Organic Field-Effect Transistors

Recent Advances in Immobilization Strategies for Biomolecules in Sensors Using Organic Field-Effect Transistors

Transistors for Chemical Monitoring of Living Cells

A Review of Carbon Nanotubes Field Effect-Based Biosensors

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