Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation

Gibot, Sébastien; Jolly, Lucie; Lemarié, Jérémie; Carrasco, Kévin; Derive, Marc; Boufenzer, Amir

doi:10.3389/fimmu.2019.02314

Cited by 22 publications

(27 citation statements)

References 30 publications

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“…The likelihood of pulmonary infection may also increase when the tracheal intubation airbag is over-inflated and compresses the tracheal mucosa, resulting in ischemia which can promote lung infection (10). Restricted postoperative thoracic movement resulting from a painful incision, chest drainage tube irritation, or tight chest strap, and the general reduction in airflow velocity and cough force seen in some cancer patients can lead to difficulty discharging sputum, further increasing the probability of infection (11,12). Most patients after surgery also have a limited amount of body fluids and an increased flow of inhaled oxygen, which can easily lead to thick sputum which is difficult to cough up (13).…”

Section: Discussionmentioning

confidence: 99%

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Liu¹,

Tian²,

You³

et al. 2021

Ann Palliat Med

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Background: To analyze the predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT), and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment. Methods:We enrolled 80 patients who underwent radical surgery for cervical cancer in our hospital from March 2018 to March 2020 and divided them into an infected group (n=34) and non-infected group (n=46) according to whether they were complicated by lung infection after surgery. The levels of CRP, PCT, and TREM-1 were compared between the two groups, and logistic regression was used to analyze the risk factors for pulmonary infection. The ROC curve was used to analyze the predictive value of the individual detection of CRP, PCT, or TREM-1 as well as their combined detection. Results:The levels of CRP, PCT, and TREM-1 in the infected group were higher than those in non-the infected group 24 h after operation (P<0.05) and tumor TNM staging, previous lung disease, postoperative use of a ventilator, intraoperative use of antibacterial drugs, PCT, CRP, and ICAM-1 were significantly correlated with pulmonary infection (P<0.05). The postoperative application of a ventilator, PCT (increasing), CRP (increasing), and ICAM-1 (increasing) were all individual factors that could affect the development of pulmonary infection (P<0.05). ROC curve results showed that the critical score of combined detection was 3.026, and the area under the curve (AUC) was 0.786 (0.637-0.935), the sensitivity was 90.52%, and the specificity was 89.63%. Conclusions:The levels of PCT, CRP, and TREM-1 are abnormally increased in patients with pulmonary infection after laparoscopic general anesthesia for cervical cancer treatment. Their combined detection can be used as an effective means to predict the occurrence of pulmonary infections in the early stage and their level should direct timely intervention to improve the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Liu¹,

Tian²,

You³

et al. 2021

Ann Palliat Med

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show abstract

“…The transmembrane and soluble(or secreted) forms have two relevant forms. The soluble form of TREM-1(sTREM-1) is secreted into body fluid, including plasma, pleural effusion, sputum, and urine, and TREM-1 activation is assessed by the measurement of its sTREM-1 in plasma (69,72). Neutrophils and mature monocytes predominantly express it.…”

Section: Biomarkers Of Inflammation -High Sensitivity C-reactive Proteinmentioning

confidence: 99%

Biomarkers of Inflammation and Oxidative stress in the Prediction and Management of Acute Coronary Syndrome

Ralapanawa¹,

Sivakanesan²

2022

Health Sci

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The assessment of patients presenting with chest pain or symptoms indicative of cardiac ischemia remains a diagnostic challenge. Many types of research have focused on the search for ideal biological markers for the rapid detection of cardiac cell injuries. Markers of inflammation and oxidative stress are the way forward. At present, the biomarker most widely used for diagnosing acute coronary syndrome is cardiac troponin though it has some limitations. Apart from cardiac troponin, several other biomarkers, especially inflammation and oxidative stress markers in acute coronary syndrome, have been investigated. However, most of them still require validation in further studies. As markers of inflammation and oxidative stress address a particular aspect of the pathophysiology of acute coronary syndrome, these biomarkers may provide unique information to the managing clinician separate from that of markers of myocyte necrosis. Serum markers of inflammation and oxidative stress appear before cardiac necrosis markers and are valuable targets for early and timely diagnosis of an acute cardiac event. Using these markers in combination with biomarkers of plaque formation, unstable plaque development, plaque rupture, thrombosis, and myocardial necrosis (multimarker approach) could increase their diagnostic and prognostic value.

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“…TREM-1 is an immunoreceptor expressed mostly on neutrophils and monocytes/macrophages. Interestingly, TREM-1 is also identified on endothelial cells and regulates thrombin generation [23,24] .…”

Section: Trem-1 Was Essential To Ox-ldl-inducedeffect On Dendritic mentioning

confidence: 99%

TREM-1 modulates dendritic cell maturation and dendritic cell–mediated T cell activation induced by ox-LDL

Wang

Han

et al. 2020

Preprint

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Background: Triggering receptor expressed on myeloid cells (TREM)-1is identified as a major upstream proatherogenic receptor. However, the cellular processes modulated by TREM-1 in the development of atherosclerosis and plaque destabilization has not been fully elucidated. In this study, we investigated the effects of TREM-1 on dendritic cell maturation and dendritic cell–mediated T-cell activation induced by oxidized low-density lipoprotein (ox-LDL) in atherogenesis. Methods: Human peripheral blood monocytes were differentiated to dendritic cells and stimulated by ox-LDL. Naive autologous T cells were co-cultured with pretreated dendritic cells.The expressionof TREM-1 and the production of inflammatory cytokines were assessed by real-time PCR, western blot and ELISA.The expression of immune factors was determined with FACS to evaluate dendritic cell maturation and T-cell activation. Results: Stimulation with ox-LDL promoted dendritic cell maturation, TREM-1 expression and T-cell activation, and exposure of T cells to ox-LDL-treated dendritic cells induced production of interferon-γ and IL-17. Blocking TREM-1 suppressed dendritic cell maturation with low expression of CD1a, CD40, CD86 and HLA-DR, decreased production of TNF-α, IL-1β, IL-6 and MCP-1, and increased secretion of TGF-β and IL-10. In addition, stimulation of ox-LDL induced miR-155, miR-27, Let-7c and miR-185 expression, whereas inhibition of TREM-1 repressed miRNA-155. Silencing TREM-1 or miRNA-155 increased SOCS1 expression induced by ox-LDL. T cells derived from carotid atherosclerotic plaques or healthy individuals showed similar result patterns. Conclusion: These data suggest that TREM-1 modulates maturation of dendritic cells and activation of plaque T cells induced by ox-LDL, a pivotal player in atherogenesis.

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Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation

Cited by 22 publications

References 30 publications

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Biomarkers of Inflammation and Oxidative stress in the Prediction and Management of Acute Coronary Syndrome

TREM-1 modulates dendritic cell maturation and dendritic cell–mediated T cell activation induced by ox-LDL

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