Triggered C‐reactive protein (CRP) concentrations and the CRP gene −717A>G polymorphism in acute stroke or transient ischemic attack

Abstract

C-reactive protein (CRP) increases following an acute stroke/transient ischemic attack (TIA), but the increment level varies among patients. We analyzed CRP concentrations during an acute stroke/TIA in relation to the CRP gene -717A>G polymorphism. Six months following an acute ischemic stroke/TIA, basal concentrations of CRP were measured in 507 controls and 219 patients and were found to be unassociated with the CRP -717A>G polymorphism. However, during the acute phase of stroke/TIA, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027). In addition, significant 3.22-fold increments in CRP concentrations was noted in individuals carrying the -717G allele when comparing the acute phase with the basal state of each patient and averaging the results. CRP -717A>G polymorphism is associated with triggered CRP concentrations during acute stroke/TIA. These findings might shed more light on the mechanisms of CRP elevation in acute ischemic stroke/TIA.

C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population

“…Alternatively, population stratification caused by inappropriate sampling could be an influence. However, the allelic frequencies for the -717A>G polymorphism in ischemic stroke patients were actually quite similar to the previously published data [33] , suggesting that the possibility of a false association was low. Finally, false positive results due to genotyping errors are also very unlikely.…”

“…The transition of -717A>G creates a potential binding site for glucocorticoid receptor (GR), which may result in changes in CRP expression. Consistent with this model, previous studies demonstrated that the -717G allele was associated with elevated CRP concentrations during the acute phase of stroke or transient ischemic attack [33] . Alternatively, population stratification caused by inappropriate sampling could be an influence.…”

“…These two haplotypes differed only by the -717G and +2147C alleles. Previous studies have indicated that -717G and +2147C alleles are associated with high CRP levels [33,34] . Therefore, this may explain why the H3 haplotype is associated with increased risk of ischemic stroke.…”

Aqueous Extract of Carica Papaya Linn Roots Halts Sodium Arsenite-Induced Renal Inflammation through Inhibiting Adenosine Deaminase, 8-Hydroxy-2′-Deoxyguanosine, C-Reactive Protein and Inducible Nitric Oxide Synthase Activity

“…Serum C-reactive protein (CRP) was measured according to the method described previously (22) by ELISA technique using kits purchased from DIA MED (Belgium).…”

The effects of simvastatin on the C-reactive protein level and lipid profile in the acute phase of ischaemic stroke in relation to -717A>G CRP gene polymorphism

“…Significant increments in CRP concentrations in individuals carrying the -717G allele in the acute phase of stroke were found when compared with the baseline state [23]. Other authors did not observe any effect of the above-mentioned SNP on CRP level [19,20,24,25].…”