Trigeminal Neuralgia: Its Treatment With a New Anticonvulsant Drug (G-32883)

Blom, S

doi:10.1016/s0140-6736(62)91847-0

Cited by 314 publications

(94 citation statements)

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“…AEDs have a long history in the treatment of pain, especially neuropathic in origin, dating back to case reports for the treatment of trigeminal neuralgia with phenytoin in 1942 and carbamazepine in 1962 [35]. The proposed mechanisms for the efficacy of anticonvulsants with regard to treating pain are thought to include blocking abnormally high-frequency and spontaneous firing in afferent neurons in the dorsal horn and in the thalamus.…”

Section: Antiepileptic Drugs and Painmentioning

confidence: 99%

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

Nejad

Chuang²,

Hirschberg³

et al. 2014

IJCM

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Antiepileptic drugs (AEDs), have demonstrated efficacy treating a number of acute conditions, encompassing a broad range of symptoms and syndromes, in addition to being first-line treatment for epilepsy. Clinically, since their inception, AEDs have been used off-label for acute and chronic medical conditions, both as primary and as adjuvant therapies. In this review, we describe the observed clinical effectiveness of AEDs across a set of commonly encountered acute conditions in the general hospital: traumatic brain injury, pain, alcohol withdrawal. In describing the individual benefits and usages of specific agents, the applicability of these agents to other common neuropsychiatric conditions may be further explored.

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Section: Antiepileptic Drugs and Painmentioning

confidence: 99%

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

Nejad

Chuang²,

Hirschberg³

et al. 2014

IJCM

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“…In 1962, efficacy of the new anticonvulsant carbamazepine (Tegretol [Novartis]) in trigeminal neuralgia patients was reported in the journal Lancet. 13 These reports represented significant advances in the pharmacological management of trigeminal neuralgia for which primarily surgical or ablative options were previously available. Controlled studies of the use of sodium channel blocking anticonvulsants in neuropathic pain are listed in Table 1.…”

Section: History Of the Use Of Systemic Sodium Channel Blockers For Painmentioning

confidence: 99%

Sodium Channel Blockers for the Treatment of Neuropathic Pain

2009

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Summary:Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain.

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“…It first began to be used for trigeminal neuralgia after the publication in Lancet in 1962 of a report by Blom describing its successful use in a series of patients with this condition. 68 Because previous pharmacotherapies for this condition had been almost uniformly unsuccessful, the fact that carbamazepine worked at all was remarkable. Two double-blind, placebocontrolled, crossover studies 69,70 subsequently provided definitive scientific evidence for the efficacy of carbamazepine in the treatment of trigeminal neuralgia.…”

Section: Carbamazepine For Neuropathic Painmentioning

confidence: 99%