Trigeminal Neuralgia in Two Patients With Glioblastoma

Heß, Barbara; Oberndorfer, Stefan; Urbanits, Sabine; Lahrmann, Heinz; Horvath-Mechtler, Barbara; Grisold, Wolfgang

doi:10.1111/j.1526-4610.2005.00253_3.x

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Little is known about drug treatment of pain in patients with brain tumors, which might also be due to several pathogenetic factors (hydrocephalus, swelling caused by tumor mass, cranial nerve infiltration, or infiltration of the meninges, treatment-related diffuse pain resulting from immobilization, plateau waves, etc.). [14][15][16][17] Opioids seem to be appropriate in the treatment of respiratory distress in cancer patients in the terminal phase of the disease. [18][19][20] This might be also true for equivalent symptoms in brain tumor patients, however no valid data are available.…”

Section: Discussionmentioning

confidence: 99%

The End-of-Life Hospital Setting in Patients with Glioblastoma

Oberndorfer¹,

Lindeck‐Pozza²,

Lahrmann³

et al. 2008

Journal of Palliative Medicine

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Despite aggressive treatment, outcome of patients with glioblastoma is poor. Several distinct clinical problems arise in the terminal stage of this disease. The purpose of this study was to evaluate the end-of-life phase in a hospital setting in patients with glioblastoma. Twenty-nine consecutive patients with glioblastoma, who died in our department, were included in this analysis regarding symptoms, medication, diagnostics, and interventional procedures. The patients were comparable with respect to age, gender, and overall survival with data from the literature. Relevant clinical symptoms, medications, diagnostics, well as interventional procedures increased continuously toward end of life. Pain, epileptic seizures, and symptoms of brain edema were the most frequent clinical symptoms. According to this, most patients were on antiepileptic drugs (AED), steroids, and analgesics. In the last phase, symptoms from brain edema, fever, decrease of vigilance, dysphagia, and pneumonia were the prominent clinical features. Our study demonstrates that the end of life in patients with glioblastoma has several periods with different clinical aspects with respect to symptoms and treatment.

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Section: Discussionmentioning

confidence: 99%

The End-of-Life Hospital Setting in Patients with Glioblastoma

Oberndorfer¹,

Lindeck‐Pozza²,

Lahrmann³

et al. 2008

Journal of Palliative Medicine

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“…[12459] There are also other etiologies mentioned for TN including, infiltration of the nerve root, Gasserian ganglion or branches by a tumor or amyloidoma,[1391112] small infarcts, angioma or cavernoma in the pons, medulla, or REZ,[12716] chemical irritation by neoplastic factors,[2111214] herniation of the temporal lobe,[2] chronic subdural hematoma, hydrocephalous[4] posterior fossa tumors,[5–814] contralateral posterior fossa tumors,[58] ipsilateral and contralateral supra tentorial tumors,[468912] basilar invagination,[8] and Chiari malformation. [10]…”

Section: Discussionmentioning

confidence: 99%

Trigeminal neuralgia as the initial manifestation of temporal glioma: Report of three cases and a review of the literature

Khalatbari

Amirjamshidi²

2011

Surg Neurol Int

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Background:It is almost an accepted scenario that trigeminal neuralgia (TN) occurs when there is a kind of vascular compression on the root entry zone of trigeminal nerve at pons. There are occasional reports about trigeminal neuralgia as the presenting sign of intracranial tumors but temporal glioma has rarely been included in the list.Case Description:We report three cases of temporal lobe glioma which presented with trigeminal neuralgia as the initial manifestation and review the relevant literature briefly. The patients were 19-, 20-, and 31-year-old males who presented with partially controlled TN. The tumor mass could be detected in paraclinical evaluations when the usual modalities of therapy for facial pain in our community were not effective. Excisional surgery led in full pain control in all the cases. Two of the patients died because of tumor recurrence after a year and the other one is being treated by adjuvants.Conclusion:We add these types of intracranial tumors to the list of the etiologies for TN and the possible mechanisms for the initiation of pain in these types of intracranial tumors are discussed.

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“…Recent literature has enlarged the differential diagnosis of TN to include several rare causative lesions. Compression of the trigeminal nerve resulting in paroxysmal pain has been described in exceptional cases of Chiari malformation [15], Dandy-Walker cyst [16], and glioblastoma [17]. Posterior fossa arteriovenous malformations may give rise to TN [18].…”

Section: Discussionmentioning

confidence: 99%