Trigeminal neuralgia in pontine cavernous angioma

Shimpo, T

doi:10.1007/pl00007795

Cited by 20 publications

(9 citation statements)

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“…These results are in line with other short- and long-term real-world postmarketing studies [11,12,13,14,15,16,17,18,19,20,21]. Nevertheless, 2 previous head-to-head trials, EVIDENCE [9] and INCOMIN [10], showed superior efficacy for SC IFNβ compared with IM IFNβ in terms of time to the first clinical MS relapse on study.…”

Section: Discussionsupporting

confidence: 73%

“…Several open-label, postmarketing, observational studies have reported similar efficacy for the three different IFNβ preparations [11,12,13,14,15,16,17,18,19], but only a few have compared these DMTs and GA [20,21]. There is only one report in the literature comparing the effects of all four different immunomodulatory therapies on MS disease progression in patients with relapsing-remitting MS (RRMS); however, the study groups were quite imbalanced, and the reported differences in hazard ratios between the DMTs were attributed to selection bias [22].…”

Section: Introductionmentioning

confidence: 99%

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Swiss Analysis of Multiple Sclerosis: A Multicenter, Non-Interventional, Retrospective Cohort Study of Disease-Modifying Therapies

Gobbi

Zecca

Linnebank³

et al. 2013

Eur Neurol

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Background: There is a scarcity of reports comparing efficacy and tolerability of the multiple sclerosis (MS) disease-modifying therapies [DMTs; intramuscular interferon-β1a (IM IFNβ-1a), subcutaneous (SC) IFNβ-1a, SC IFNβ-1b, SC glatiramer acetate (GA)] in a real-world setting. Methods: This multicenter, non-interventional, retrospective cohort study analyzed data from 546 patients with clinically isolated or relapsing-remitting MS constantly treated with one DMT for 2 years. Annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS) scores, and DMT tolerability were assessed. Results: Demographic data were comparable across DMTs. There were no significant differences between DMT groups in ARR during study year 1 (p = 0.277) or study year 2 (p = 0.670), or in EDSS change between years 1 and 2 (p = 0.624). Adverse events were frequent (39-56%) in all groups. Flu-like symptoms were less frequent with GA treatment (2.3% vs. IM IFNβ-1a, 46.7%; SC IFNβ-1a, 39.8%; SC IFNβ-1b, 25.8%; p < 0.05). Injection site reactions were less often reported with IM IFNβ-1a (10.5% vs. SC IFNβ-1a, 33.9%; SC IFNβ-1b, 38.3%; GA, 26.1%; p < 0.05). Conclusions: All DMTs showed comparable effects on MS relapse rate and EDSS change, with IM IFNβ-1a and GA being more tolerable with respect to injection site reactions and flu-like symptoms, respectively.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Swiss Analysis of Multiple Sclerosis: A Multicenter, Non-Interventional, Retrospective Cohort Study of Disease-Modifying Therapies

Gobbi

Zecca

Linnebank³

et al. 2013

Eur Neurol

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“…Conservative management, consisting of medication or observation, may be a viable first treatment option. One patient’s pain resolved with observation, while the 2 other patients achieved good pain control medically [4, 5, 8]. …”

Section: Discussionmentioning

confidence: 99%

Gamma Knife Radiosurgery for Trigeminal Neuralgia Caused by a Cavernous Malformation: Case Report and Literature Review

Pease

Withrow

Ozpinar

et al. 2018

Stereotact Funct Neurosurg

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Objective: Trigeminal neuralgia (TN) related to a brainstem cavernous malformation (CM) is a rare entity. We present the first radiosurgical management of a patient with TN secondary to a CM. Clinical Presentation: An 80-year-old female presented with a 33-year history of progressively severe TN refractory to medications. Imaging confirmed a solitary CM located at the pontine dorsal root entry zone of cranial nerve 5. Treatment: Stereotactic radiosurgery of the trigeminal nerve was performed using the Leksell gamma knife. A single 4-mm isocenter of radiation was focused on the trigeminal nerve and a maximum dose of 80 Gy (40 Gy at the 50% isodose line) was delivered to the nerve. Results: At 1 year, the patient noted that the severe pain attacks had been reduced by 75%, although a background lingering discomfort persisted. Pain suppression medications had been significantly reduced to lamotrigine 100 mg twice daily. Her preoperative distribution of sensory dysfunction mildly increased. Conclusion: For medically refractory TN related to a CM, radiosurgery of the afferent nerve may ameliorate pain without a major decrease in sensation. The more than 30-year history of pain in our patient may have reduced the chance of more significant pain relief.

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“…Trigeminal neuralgia was caused by a dilated petrosal vein [7], a draining vein from venous angioma [8,14], the superior cerebellar artery and a dilated draining vein at two different points [9] and by the anterior inferior cerebellar artery together with a dilated petrosal vein [6]. Only 1 case in the literature was caused by direct compression of the intra-axial trigeminal nerve root [15]. This case of trigeminal neuralgia resulting from a cavernous angioma in the brachium pontis seems to be the second reported in the literature caused by direct compression of the intra-axial trigeminal nerve root.…”

Section: Discussionmentioning

confidence: 99%

Cavernous Angioma in the Brachium pontis Presenting with Trigeminal Neuralgia: A Case Report

Vitek¹,

Tettenborn²

2002

Eur Neurol

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Trigeminal neuralgia in pontine cavernous angioma

Cited by 20 publications

References 0 publications

Swiss Analysis of Multiple Sclerosis: A Multicenter, Non-Interventional, Retrospective Cohort Study of Disease-Modifying Therapies

Swiss Analysis of Multiple Sclerosis: A Multicenter, Non-Interventional, Retrospective Cohort Study of Disease-Modifying Therapies

Gamma Knife Radiosurgery for Trigeminal Neuralgia Caused by a Cavernous Malformation: Case Report and Literature Review

Cavernous Angioma in the Brachium pontis Presenting with Trigeminal Neuralgia: A Case Report

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