Trigeminal neuralgia in an octogenarian: Sustained clinical response to acupuncture

Mishra, Deepti; Raji, Mukaila; Sierpina, Victor S.

doi:10.1016/j.explore.2004.10.007

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…AC has been showed to decrease the pain score and muscle strength in post-zoster limb pain and paresis in shingles [55]. Lastly, Mishra et al described a case of persistent, recurring trigeminal neuralgia in an octogenarian that was resistant to medical therapy but showed a sustained clinical response to AC [56]. Positive outcomes for AC in distinct neuropathies bodes well for its eventual clinical use and, pending validation through further research, a broader scope of potential treatment options for many neuropathies, including HIV-SN.…”

Section: Tart Cherry Extractsmentioning

confidence: 99%

HIV-Related Neuropathy: Pathophysiology, Treatment and Challenges

Jazebi¹,

Evans²,

Kadaru³

et al. 2021

J Neurol Exp Neurosci

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HIV-sensory neuropathy (HIV-SN) is a debilitating complication in HIV patients with or without anti-retroviral treatment (ART). Common symptoms of HIV-SN include pain, decreased sensation, paresthesias and dysesthesias in a symmetric stocking-glove distribution. While HIV-1 protein such as gp120 is implicated in HIV-SN (e.g. impaired large-diameter fiber), ART itself was recently shown to contribute to HIV-SN in HIV patients and impair thin fiber. Multiple host mechanisms may play roles during the pathogenesis of HIV-SN, including neuron-glia interactions in the spinal dorsal horn (SDH), inflammation, mitochondrial dysfunction and endoplasmic reticulum stress. Concurrent infections, such as tuberculosis, also carry a higher likelihood of HIV-SN as well as environmental or genetic predisposition. Pro-inflammatory cytokines such as IL-1, IL2 receptor-alpha and tumor necrosis factor (TNF) along with abnormal lactate levels have been identified as potential players within the complex pathophysiology of this condition. In this paper, we review the pathophysiology of HIV neuropathy, focusing on the various treatment options available or under investigation. Although several treatment options are available e.g., the capsaicin patch and spinal cord stimulation, symptomatic control of HIV-SN are often challenging. Alternative approaches such as self-hypnosis, resistance exercise, cannabinoids, and acupuncture have all shown promising results, but need further investigation.

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Section: Tart Cherry Extractsmentioning

confidence: 99%

HIV-Related Neuropathy: Pathophysiology, Treatment and Challenges

Jazebi¹,

Evans²,

Kadaru³

et al. 2021

J Neurol Exp Neurosci

View full text Add to dashboard Cite

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“…Acupuncture, a complementary medicine modality, has been demonstrated to have analgesic effects with low rates of complications. Possible mechanisms of action including suppression of nociceptive pathways and modulation of tissue perfusion and electrolytes concentrations across neuronal membranes [11][12][13][14]. In recent years, acupuncture has been increasingly used in patients with trigeminal neuralgia, which has been identified by the World Health Organization as one of the medical conditions that may be effectively treated with acupuncture [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Magnetic Resonance Imaging and Adjunct Acupuncture on LongTerm Pain Improvement for Patients with Trigeminal Neuralgia

2020

JAPM

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Trigeminal neuralgia is a debilitating disease characterized by neuropathic facial pain which significantly impact on the patient’s quality of life and socioeconomic function. For patients with trigeminal neuralgia, Magnetic Resonance Imaging (MRI) is a routine investigation recommended in recent clinical guidelines but it remains unclear whether its use has any impact on patient-reported clinical outcomes. Acupuncture as an adjunct therapy has been shown to provide short term pain relief but its longer-term benefits remain unknown. The aims of the study are to examine whether the use of MRI and/ or adjunct acupuncture is associated with the long-term pain improvement for trigeminal neuralgia patients, and thus to inform on prognosis of trigeminal neuralgia. Methods: In this retrospective cohort study using data from routine clinical practice, we included all adult patients diagnosed with trigeminal neuralgia and managed at the Pain Management Centre, Singapore General Hospital between 2011 and 2017. Patients who have incomplete clinical data or lost to follow up are excluded. Logistic regression model was used to examine the association between the uses of MRI or adjunct MRI and pain symptom improvement at 6-12 months follow up. Results: Fifty-three patients were identified and included in this study. Neither the use of MRI nor acupuncture was found to be significantly associated with pain improvement for patients with trigeminal neuralgia at 6 to 12 months follow up after the initial diagnosis. Conclusion: The use of MRI or adjunct acupuncture did not seem to be related to long-term pain improvement for patients with trigeminal neuralgia and thus has limited prognostic value. These findings would have to be confirmed by further studies of larger sample size, and ideally with prospective randomized clinical trials.

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