Trigeminal Neuralgia

Aziz, Mohammed Ben; Cascella, Marco; Monaco, Federica; Khalifé, Maher; Napoli, Raffaela Di

doi:10.1016/b978-0-12-820472-6.00180-8

Cited by 1 publication

(1 citation statement)

References 63 publications

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“…This is the simplest and most direct way in severe emergency cases. And intracerebral administration can protect against the activity of neurons, and it has an excellent analgesic effect [104]. Intracerebral administration is now a practical therapeutic approach for specific therapeutic proteins and targeted diseases.…”

Section: Intracerebral Administrationmentioning

confidence: 99%

The role of exosomes in central nervous system tissue regeneration and repair

Wang

Yang

2023

Biomed. Mater.

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Exosomes are membrane-bound vesicles secreted by various cell types into the extracellular environment, and contain kinds of bioactive molecules. These molecules can mediate various biological processes such as cell differentiation, proliferation, and survival, making them attractive for tissue regeneration and repair. Owing to their nanoscale-size, bilayer membrane structure and receptor-mediated transcytosis, exosomes can cross the blood-brain barrier (BBB) and reach the central nervous system (CNS) tissue. Additionally, exosomes can be loaded with exogenous substances after isolation. It has been suggested that exosomes could be used as natural drug carriers to transport therapeutic agents across the BBB and have great potential for CNS disease therapy by promoting tissue regeneration and repair. Herein, we discuss perspectives on therapeutic strategies to treat neurodegenerative disease or spinal cord injury using a variety of cell types-derived exosomes with kinds of exosomal contents, as well as engineering strategies of specific functional and exosome administration routes.

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Section: Intracerebral Administrationmentioning

confidence: 99%