Trigeminal Nerve Stimulation (TNS) for Major Depressive Disorder in Pregnancy: A Case Study

Trevizol, Alisson Paulino; Sato, Isa Albuquerque; Bonadia, Bianca; Liquidato, Bianca Maria; Barros, Mirna Duarte; Cordeiro, Quirino; Shiozawa, Pedro

doi:10.1016/j.brs.2015.07.034

Cited by 10 publications

(5 citation statements)

References 11 publications

(17 reference statements)

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“…The impact on quantitative electroencephalography was reported in one patient with MDD treated with TNS, with changes that correlated to the improvements in depressive symptoms (20). The authors also reported one case of MDD during pregnancy with complete remission of depressive symptoms without any pharmacological intervention, with no unwanted consequences for childbirth or newborns (21). The TNS was reported to be a well-tolerated technique, with no severe adverse effect reported, and to have impressive results for MDD.…”

Section: Literature Reviewmentioning

confidence: 85%

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trevizol

Cordeiro

2016

Arch Neurosci

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Context: Trigeminal nerve stimulation (TNS) is a promising non-invasive brain stimulation intervention. The TNS has been proposed for major depressive disorder (MDD) with auspicious results. The aim of this study was to review the literature on TNS for MDD. Evidence Acquisition: Systematic review, using MEDLINE and EMBASE, of first articles available until 22nd of April 2016. Results: We included seven studies; six of them were open-label studies and one sham-controlled randomized double-blinded trial. Most studies had small sample sizes. Two studies were on MDD with comorbid posttraumatic stress disorder and one study focused on the elderly population. Two different protocols of stimulation were reported. Studies had interesting positive results for treating MDD. Conclusions:The TNS was reported to be well tolerated, with no severe adverse effect reported, and had impressive results for MDD. This promising, safe and easy-to-use new neuromodulation technique could be a useful tool for MDD treatment. However, the results reported in the studies performed so far must be analyzed under the strict limitations of the study design. Most of the studies on TNS are case studies or open-label trials with very small sample sizes. We acknowledge that it is the time to initiate more rigorous sham-controlled trials to better understand the huge potential involved with this technique, which could lead to the development of more accessible, easy-to-use, safe and non-invasive technology.

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Section: Literature Reviewmentioning

confidence: 85%

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trevizol

Cordeiro

2016

Arch Neurosci

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“…Of these, tDCS use was reported in one conference abstract presenting the preliminary results of an open-label single-arm pilot study with three patients [ 84 ], one case report [ 85 ], and one small RCT with 10 patients in the active group [ 86 ]. Trigeminal Nerve Stimulation use was reported in one case study [ 87 ], and tACS was reported in another case study [ 88 ].…”

Section: Updates To Warnings and Precautions: General Approachmentioning

confidence: 99%

Limited output transcranial electrical stimulation 2023 (LOTES-2023): Updates on engineering principles, regulatory statutes, and industry standards for wellness, over-the-counter, or prescription devices with low risk

et al. 2023

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“…All 3 patients treated their attacks repeatedly during pregnancy and reported some degree of benefit, with no labor or delivery complications with healthy children. Vagus nerve stimulation and trigeminal nerve stimulation have been reported in patients with non‐headache indications such as depression and epilepsy without any clear signal of teratogenicity attributable to the devices . A case was also reported of a woman with chronic cluster headache who effectively used occipital nerve stimulation as a preventive therapy throughout her pregnancy; the device had already been implanted and used preconception .…”

Section: Neuromodulation In Special Populationsmentioning

confidence: 99%

“…Vagus nerve stimulation and trigeminal nerve stimulation have been reported in patients with non-headache indications such as depression and epilepsy without any clear signal of teratogenicity attributable to the devices. 61,62 A case was also reported of a woman with chronic cluster headache who effectively used occipital nerve stimulation as a preventive therapy throughout her pregnancy; the device had already been implanted and used preconception. 63 No adverse labor or delivery outcomes occurred.…”

Section: Neuromodulation In Special Populationsmentioning

confidence: 99%

Neuromodulation for the Acute and Preventive Therapy of Migraine and Cluster Headache

2019

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Headache disorders are among the most common and disabling medical conditions worldwide. Pharmacologic acute and preventive treatments are often insufficient and poorly tolerated, and the majority of patients are unable to adhere to their migraine treatments due to these issues. With improvements in our understanding of migraine and cluster headache pathophysiology, neuromodulation devices have been developed as safe and effective acute and preventive treatment options. In this review, we focus on neuromodulation devices that have been studied for migraine and cluster headache, with special attention to those that have gained food and drug administration (FDA) clearance. We will also explore how these devices can be used in patients who might have limited pharmacologic options, including the elderly, children, and pregnant women.

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Trigeminal Nerve Stimulation (TNS) for Major Depressive Disorder in Pregnancy: A Case Study

Cited by 10 publications

References 11 publications

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Limited output transcranial electrical stimulation 2023 (LOTES-2023): Updates on engineering principles, regulatory statutes, and industry standards for wellness, over-the-counter, or prescription devices with low risk

Neuromodulation for the Acute and Preventive Therapy of Migraine and Cluster Headache

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