Trigeminal main sensory nucleus polymodal unit responses to noxious and non-noxious stimuli

Yu, Young J.; King, Robert B.

doi:10.1016/0006-8993(74)90658-1

Cited by 15 publications

(6 citation statements)

References 15 publications

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“…The response properties of the two populations of PM neurons are similar in the following respects (Beaudreau and Jerge, 1968;Linden, 1978): The great majority of PM neurons are sensitive to only one tooth (in particular, the canine tooth); they are slowly adaptive and directionally selective to mechanical stimulation of the tooth; and they respond to a stimulation force of less than 0.03 N. The central branches of the trigeminal ganglion neurons project ipsilaterally to the secondary Vms and Vst neurons (Darian-Smith, 1973; Linden, 1990). Support for our findings is provided by previous reports that most PM units are located in the rostral part of Vst (Eisenman et al, 1963;Kawamura and Nishiyama, 1966;Yu and King, 1974;Khayyat et al, 1975;Woda et al, 1983). Support for our findings is provided by previous reports that most PM units are located in the rostral part of Vst (Eisenman et al, 1963;Kawamura and Nishiyama, 1966;Yu and King, 1974;Khayyat et al, 1975;Woda et al, 1983).…”

Section: Discussionsupporting

confidence: 85%

Response Properties of Periodontal Mechanosensitive Neurons in the Trigeminal Spinal Tract Nucleus of the Cat

Tabata

Karita

1991

Somatosensory & Motor Research

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Periodontal mechanosensitive (PM) units were recorded from the trigeminal spinal tract nucleus (Vst) of the cat. The Vst is divided into three subnuclei: oralis (Vo), interpolaris (Vi), and caudalis (Vc). The receptive fields of PM units in Vo and Vi were arranged in a dorsoventral sequence in the mandibular to maxillary divisions, and those in Vc were arranged in a mediolateral sequence. The majority of Vo units were single-tooth ones, whereas more than half the Vi units and all the Vc ones were multitooth units. The PM units in each subnucleus were predominantly responsive to canine tooth stimulation. Most of the PM units in Vo and Vi gave sustained responses to pressure applied to the tooth, were directionally selective, and were most actively excited by canine tooth stimulation in the caudomedial or rostrolateral direction. Vc units, however, were transient. The threshold intensity for firings by canine tooth stimulation was less than 0.05 N. These findings indicate that only the response properties of PM units in the rostral part of Vst resemble those of the trigeminal main sensory nucleus neurons and primary afferent nerves.

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Section: Discussionsupporting

confidence: 85%

Response Properties of Periodontal Mechanosensitive Neurons in the Trigeminal Spinal Tract Nucleus of the Cat

Tabata

Karita

1991

Somatosensory & Motor Research

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“…Nociceptive, thermal and high threshold mechanoreceptive primary afferent fibers project to lamina I, II, and V (Biedenbach, 1973; Mosso and Kruger, 1973; Nord and Ross, 1973; Price et al, 1976; Hu et al, 1981; Azerad et al, 1982). In addition, nociceptive specific, thermal and wide dynamic range neurons have been reported in pV (Eisenman et al, 1963; Yu and King, 1974; Khayyat et al, 1975), and sVo (Eisenman et al, 1963; Davies et al, 1971; Tamarova et al, 1973). Thus, the ascending intratrigeminal pathway, arising from sVc neurons may provide a circuit by which nociceptive signals in lamina I/II provide the nociceptive fields observed in pV/sVo cells, and low threshold mechanical signals in layers III/IV can modify activity of similar neurons in pV/sVo (Denney-Brown and Yanagisawa, 1973; Sessle and Greenwood, 1974; Yu and King, 1974; Khayyat et al, 1975; Greenwood and Sessle, 1976; Shigenaga et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, nociceptive specific, thermal and wide dynamic range neurons have been reported in pV (Eisenman et al, 1963; Yu and King, 1974; Khayyat et al, 1975), and sVo (Eisenman et al, 1963; Davies et al, 1971; Tamarova et al, 1973). Thus, the ascending intratrigeminal pathway, arising from sVc neurons may provide a circuit by which nociceptive signals in lamina I/II provide the nociceptive fields observed in pV/sVo cells, and low threshold mechanical signals in layers III/IV can modify activity of similar neurons in pV/sVo (Denney-Brown and Yanagisawa, 1973; Sessle and Greenwood, 1974; Yu and King, 1974; Khayyat et al, 1975; Greenwood and Sessle, 1976; Shigenaga et al, 1976). Alternatively, Scibetta and King (1969) have suggested that sVc maintains a hyperpolarizing influence on pV neurons, and that the interplay of cross-modal activity between nuclei may be an important feature of the neural mechanisms subserving discrimination and perception of facial stimuli.…”

Section: Discussionmentioning

confidence: 99%

Morphology and connections of intratrigeminal cells and axons in the macaque monkey

Warren¹,

May²

2013

Front. Neuroanat.

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Trigeminal primary afferent fibers have small receptive fields and discrete submodalities, but second order trigeminal neurons often display larger receptive fields with complex, multimodal responses. Moreover, while most large caliber afferents terminate exclusively in the principal trigeminal nucleus, and pars caudalis (sVc) of the spinal trigeminal nucleus receives almost exclusively small caliber afferents, the characteristics of second order neurons do not always reflect this dichotomy. These surprising characteristics may be due to a network of intratrigeminal connections modifying primary afferent contributions. This study characterizes the distribution and morphology of intratrigeminal cells and axons in a macaque monkeys. Tracer injections centered in the principal nucleus (pV) and adjacent pars oralis retrogradely labeled neurons bilaterally in pars interpolaris (sVi), but only ipsilaterally, in sVc. Labeled axons terminated contralaterally within sVi and caudalis. Features of the intratrigeminal cells in ipsilateral sVc suggest that both nociceptive and non-nociceptive neurons project to principalis. A commissural projection to contralateral principalis was also revealed. Injections into sVc labeled cells and terminals in pV and pars oralis on both sides, indicating the presence of bilateral reciprocal connections. Labeled terminals and cells were also present bilaterally in sVi and in contralateral sVc. Interpolaris injections produced labeling patterns similar to those of sVc. Thus, the rostral and caudal poles of the macaque trigeminal complex are richly interconnected by ipsilateral ascending and descending connections providing an anatomical substrate for complex analysis of oro-facial stimuli. Sparser reciprocal crossed intratrigeminal connections may be important for conjugate reflex movements, such as the corneal blink reflex.

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“…Based on comparisons with primary afferent morphology, one might expect that the thin fibers we observed convey noxious modalities. Both pV and sVo contain polymodal cells that respond to both non-noxious and noxious stimuli (Yu and King, 1974 ; Azerad et al, 1982 ; Dallel et al, 1990 ). Thus, on physiologic grounds, both pV and sVo might be expected to be the source of a thin fiber projection.…”

Section: Discussionmentioning

confidence: 99%

“…However, physiologic data exists suggesting some nociceptive signals are also present in pV (Azerad et al, 1982 ). Furthermore, there are polymodal cells in pV that respond to both noxious and non-noxious stimuli (Yu and King, 1974 ; Dallel et al, 1990 ). Veinante and Deschênes ( 1999 ) correlated the thick fibers with lemniscal-like, physiologically identified, single whisker sensitive neurons in pV.…”

Section: Discussionmentioning

confidence: 99%

Morphologic Characterization of Trigeminothalamic Terminal Arbors Arising From the Principal Nucleus in the Macaque

2020

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Trigeminal main sensory nucleus polymodal unit responses to noxious and non-noxious stimuli

Cited by 15 publications

References 15 publications

Response Properties of Periodontal Mechanosensitive Neurons in the Trigeminal Spinal Tract Nucleus of the Cat

Response Properties of Periodontal Mechanosensitive Neurons in the Trigeminal Spinal Tract Nucleus of the Cat

Morphology and connections of intratrigeminal cells and axons in the macaque monkey

Morphologic Characterization of Trigeminothalamic Terminal Arbors Arising From the Principal Nucleus in the Macaque

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