Trifluorothymidine

Heidelberger, Charles; King, Dannie H.

doi:10.1016/0163-7258(79)90062-7

Cited by 62 publications

(12 citation statements)

References 40 publications

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“…The antiviral activity and the mechanisms of action of TFT have been reviewed [245], [246]. It is converted to the active triphosphate form by cellular and viral thymidine kinases.…”

Section: Tradementioning

confidence: 99%

Chemotherapeutics

Actor¹,

Chow²,

Dutko³

et al. 2000

Ullmann's Encyclopedia of Industrial Chemistry

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“…The antiviral activity and the mechanisms of action of TFT have been reviewed [245], [246]. It is converted to the active triphosphate form by cellular and viral thymidine kinases.…”

Section: Tradementioning

confidence: 99%

Chemotherapeutics

Actor¹,

Chow²,

Dutko³

et al. 2000

Ullmann's Encyclopedia of Industrial Chemistry

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“…Additional details of F 3 dThd pharmacology were presented by Heidelberger and King (1979) and Carmine et al (1982).…”

Section: + Fmentioning

confidence: 99%

“…If fragmentation of DNA, or chemical conversion of F3dTMP in DNA to 5-carboxy dUMP with subsequent distortion of the DNA structure were to occur, then these events could also contribute to the antiviral activity (Heidelberger and King, 1979;Shannon, 1984;Carmine et al, 1982).…”

Section: Amantadinementioning

confidence: 99%

Antiviral Drug Development

Clercq¹,

Walker²

1988

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher ACKNOWLEDGEMENTS This Advanced Study Institute was sponsored by NATO (ASI no 237/86) and co-sponsored by FEBS (Advanced Course no 87/02). The Course Directors also acknowledge the financial assistance of the following companies :

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“…Many of the early antiviral agents, such as idoxuridine and trifluorothymidine, were equally good substrates for both viral and cellular kinases. Even though they were slightly better inhibitors of viral than of cellular polymerases (194,365), they were activated and capable of decreasing DNA synthesis in both infected and uninfected cells. Many of the newer nucleosides are less toxic, in part because there is at least one point in their functional pathways which is specific for virus-infected cells.…”

Section: Introductionmentioning

confidence: 99%

Antiviral therapy: current concepts and practices

Bean

1992

Clin Microbiol Rev

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Drugs capable of inhibiting viruses in vitro were described in the 1950s, but real progress was not made until the 1970s, when agents capable of inhibiting virus-specific enzymes were first identified. The last decade has seen rapid progress in both our understanding of antiviral therapy and the number of antiviral agents on the market. Amantadine and ribavirin are available for treatment of viral respiratory infections. Vidarabine, acyclovir, ganciclovir, and foscarnet are used for systemic treatment of herpesvirus infections, while ophthalmic preparations of idoxuridine, trifluorothymidine, and vidarabine are available for herpes keratitis. For treatment of human immunodeficiency virus infections, zidovudine and didanosine are used. Immunomodulators, such as interferons and colony-stimulating factors, and immunoglobulins are being used increasingly for viral illnesses. While resistance to antiviral drugs has been seen, especially among AIDS patients, it has not become widespread and is being intensely studied. Increasingly, combinations of agents are being used: to achieve synergistic inhibition of viruses, to delay or prevent resistance, and to decrease dosages of toxic drugs. New approaches, such as liposomes carrying antiviral drugs and computer-aided drug design, are exciting and promising prospects for the future.

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Trifluorothymidine

Cited by 62 publications

References 40 publications

Chemotherapeutics

Chemotherapeutics

Antiviral Drug Development

Antiviral therapy: current concepts and practices

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