Trifluoromethylpyridine piperazine derivatives: synthesis and anti‐plant virus activity

Zhang, Wei; Guo, Shengxin; Wang, Ya; Wu, Yikun; Yu, Lijiao; Wu, Jian

doi:10.1002/ps.7429

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…The curative activities and protection of the target compounds 7a – 7o against CMV in Chenopodium amaranticolor ( C. amaranticolor ) plants were assessed using the half-leaf method at a concentration of 500 mg/L, and the inhibition rate I (%) of the anti-CMV activity was calculated using the established method [ 41 ].

…”

Section: Methodsmentioning

confidence: 99%

“…The curative activities and protection of the target compounds 7a-7o against CMV in Chenopodium amaranticolor (C. amaranticolor) plants were assessed using the half-leaf method at a concentration of 500 mg/L, and the inhibition rate I (%) of the anti-CMV activity was calculated using the established method [41]. Intermediates 2-6 were prepared using 4-substituted phenol as the starting material, following the established methods described in Figure 2 [22].…”

Section: In Vivo Anti-cmv Activity Testmentioning

confidence: 99%

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Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

Wu,

Yu,

Xiao

et al. 2024

Molecules

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This study involved the design and synthesis of a series of novel 4-chromanone-derived compounds. Their in vivo anti-cucumber mosaic virus (CMV) activity in field trials against CMV disease in Passiflora spp. was then assessed. Bioassay results demonstrated that compounds 7c and 7g exhibited remarkable curative effects and protection against CMV, with inhibition rates of 57.69% and 51.73% and 56.13% and 52.39%, respectively, surpassing those of dufulin and comparable to ningnanmycin. Field trials results indicated that compound 7c displayed significant efficacy against CMV disease in Passiflora spp. (passion fruit) after the third spraying at a concentration of 200 mg/L, with a relative control efficiency of 47.49%, surpassing that of dufulin and comparable to ningnanmycin. Meanwhile, nutritional quality test results revealed that compound 7c effectively enhanced the disease resistance of Passiflora spp., as evidenced by significant increases in soluble protein, soluble sugar, total phenol, and chlorophyll contents in Passiflora spp. leaves as well as improved the flavor and taste of Passiflora spp. fruits, as demonstrated by notable increases in soluble protein, soluble sugar, soluble solid, and vitamin C contents in Passiflora spp. fruits. Additionally, a transcriptome analysis revealed that compound 7c primarily targeted the abscisic acid (ABA) signaling pathway, a crucial plant hormone signal transduction pathway, thereby augmenting resistance against CMV disease in Passiflora spp. Therefore, this study demonstrates the potential application of these novel 4-chromanone-derived compounds as effective inducers of plant immunity for controlling CMV disease in Passiflora spp. in the coming decades.

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…”

Section: Methodsmentioning

confidence: 99%

Section: In Vivo Anti-cmv Activity Testmentioning

confidence: 99%

Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

Wu,

Yu,

Xiao

et al. 2024

Molecules

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show abstract

“…Plant virus diseases are serious and difficult to cure once they occur, causing great economic losses every year [128]. There are more common types of plant viruses, such as, tobacco mosaic virus (TMV) [129,130], cucumber mosaic virus [131,132], tomato chlorotic virus [133,134], and tomato spotted wilt virus [135,136]. The use of chemical antiviral agents is currently one of the most effective methods of plant virus disease management [137][138][139][140].…”

Section: Anti-plant Virus Activitymentioning

confidence: 99%

Research progress of oxazole derivatives in the discovery of agricultural chemicals

Wang,

Song,

Cai

et al. 2023

Journal of Heterocyclic Chem

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The search for new scaffolds is one of the important goals in the discovery of new pesticides, and the oxazoles as an important five‐membered heterocyclic compound are widely used in the discovery of new pesticides. Oxazoles ring are often used as the scaffolding structure or bridging chain to connect different reactive groups. In recent years, oxazoles have made rapid progress in the discovery of new pesticides, especially in the discovery of fungicides, insecticides, and acaricides. A systematic review of the recent research progress of oxazoles in the discovery of new pesticides is of interest. Therefore, we comprehensively reviewed the application of oxazole compounds in the discovery of new pesticides from 2003 to 2023; summarized the fungicidal, antibacterial, insecticidal, acaricidal, and herbicidal activities of oxazoles; and discussed the structure–activity relationship, physiochemical and mechanism of action, with the aim of providing inspiration and ideas for the discovery of oxazoles as novel agrochemicals.

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Acyl hydrazone derivatives with trifluoromethylpyridine as potential agrochemical for controlling plant diseases

Wang,

Zhang,

Guo

et al. 2024

Pest Management Science

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BACKGROUNDCrops are consistently under siege by a multitude of pathogens. These pathogenic microorganisms, including viruses and bacteria, result in substantial reductions in quality and yield globally by inducing detrimental crop diseases, thus posing a significant challenge to global food security. However, the biological activity sepectrum of commercially available pesticides is limited and the pesticide efficacy is poor, necessitating the urgent development of broad‐spectrum and efficient strategies for crop disease prevention and control.RESULTSThe bioassay results revealed that certain target compounds demonstrated outstanding in vivo antiviral efficacy against cucumber mosaic virus and tobacco mosaic virus. In particular, compound D6 showed remarkable antiviral activity against CMV, significantly higher than that of the control agent ningnanmycin. Mechanism of action studies have shown that compound D6 could enhance the activity of defense enzymes and upregulate the expression of genes related to disease resistance, thereby enhancing the antiviral effects in plants. In addition, these compounds displayed superior inhibitory activity against plant bacterial diseases. For Xoo, compound D10 showed an excellent inhibitory effect that was better than that of the control agent bismerthiazol. Scanning electron microscopy and fluorescence double‐staining experiments revealed that compound D10 effectively inhibited bacterial growth by disrupting the cell membrane.CONCLUSIONA series of trifluoromethyl hydrazone derivatives were designed and synthesized, and it was found that they have control effects on plant viruses and bacterial diseases. In addition, this study revealed the mechanism of action of the active compounds and demonstrated their potential as multifunctional crop protectants. © 2024 Society of Chemical Industry.

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Trifluoromethylpyridine piperazine derivatives: synthesis and anti‐plant virus activity

Cited by 5 publications

References 25 publications

Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)

Research progress of oxazole derivatives in the discovery of agricultural chemicals

Acyl hydrazone derivatives with trifluoromethylpyridine as potential agrochemical for controlling plant diseases

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