“…Returning to the activity of the ligands themselves, in general halogenation enhances any biological activity [ 41 , 43 , 51 , 52 , [54] , [55] , [56] ]. However, due to the overall inactivity of SB2 (3-NO 2 -4-Cl) with the highest lipophilicity and, conversely, the activity of SB3 and the partial activity of SB7 , it is possible to hypothesize the need for specific substituents in the exact positions of the phenyl rings, namely the keyness of the NO 2 group in the meta position, which must be supplemented by another substituent in the ortho position (e.g., OH) able to form strong hydrogen bonds with a number of enzymes necessary for the survival of the bacterial cell.…”