Trifluoroethanol‐mediated Decarboxylative Addition Reactions of β‐Ketoacids with Diverse Electrophiles

Abstract

An efficient decarboxylative addition reaction of βketoacids with miscellaneous electrophiles in 2,2,2-trifluoroethanol (TFE) is reported. The reaction proceeds smoothly without any base and metal catalysts, affording a broad range of diarylmethanes, β-hydroxy ketones and 3,3-disubstituted oxindoles with moderate to excellent yields under essentially neutral conditions.