Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

TiO2‐Nanoparticles Catalyzed Synthesis of New Trifluoromethyl‐4,5‐dihydro‐1,2,4‐oxadiazoles and Trifluoromethyl‐1,2,4‐oxadiazoles

“…The results are given in Table . Unfortunately, the reaction of amidoximes 1a with trifluoroacetimidoyl chloride 2a did not produce the expected 3a or 4a , and from these reaction, hydrolyzed product 5a was isolated (Scheme and Table ) . In fact, compared with previous our works , trifluoroacetimidoyl chloride could be converted to hydrolyzed product at some condition as main or by products.…”

Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles

“…Methods of amino functional group protection have been reported by related literatures or patents [1]. Traditionally, functional groups were protected via amines reacting with CBZ-Cl [2,3], (Boc) 2 O [4,5,6], Fmoc-Cl [7], TFA [8,9] and Alloc-Cl [10] in the presence of inorganic bases. Furthermore, we have found that bases are mainly used as a promoter.…”

N‐Arylation of Fluoroalkylamine and Trifluoroacetamide through Cu–Catalysis

“…Up to now, the methodologies of N‐(fluoroalkyl/fluoroacetyl)‐aniline synthesis include the following; N‐(fluoroalkyl‐/fluoroacetyl)‐aniline can be directly prepared by combination of aniline and trifluoroethylation/trifluoroacetyl reagents (scheme a). Alternatively, the fluoroalkyl/fluoroacetyl group can be introduced by Pd or Cu‐catalyzed coupling of aryl halides and fluoroalkylamine/trifluoroacetamide (scheme b) .…”

“…[7,8] β-CF 3 amine and amide group (CF 3 CH 2 NH 2 , CF 3 CONH 2 ) have been probe more valuable than the parent aniline, thus, the synthesis of β-CF 3 aryl-amine and amide have driven much attention over the past few years. [7,[9][10][11][12][13][14][15][16][17] Up to now, the methodologies of N-(fluoroalkyl/fluoroacetyl)-aniline synthesis include the following; N-(fluoroalkyl-/ fluoroacetyl)-aniline can be directly prepared by combination of aniline and trifluoroethylation [18][19][20][21] /trifluoroacetyl reagents [22][23][24][25] (scheme 1a). Alternatively, the fluoroalkyl/fluoroacetyl group can be introduced by Pd or Cu-catalyzed coupling of aryl halides and fluoroalkylamine/trifluoroacetamide (scheme 1b).…”