Trifluoroacetylation of Amines with <i>N</i>‐Trifluoroacetyl‐Nylon 66

Schuttenberg, Herman; Schulz, Rolf C.

doi:10.1002/anie.197607771

Cited by 22 publications

(4 citation statements)

References 6 publications

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“…Polyamides are insoluble in classical organic solvents at room temperature. They become soluble in such solvents after they are subjected to reaction with trifluoroacetic anhydride (TFAA) leading to N ‐trifluoroacetylated derivatives (PA‐TFAA) 16. The latter can then be characterized by techniques such as SEC using THF as eluent 17, 18.…”

Section: Methodsmentioning

confidence: 99%

Molecular testing in malignant melanoma

Grossmann¹,

Grossmann²,

Wallander³

2012

Diagnostic Cytopathology

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Molecular testing of cancers to determine therapeutic eligibility is now standard of care and has changed the practice of pathology. Recent advances in the treatment of metastatic melanoma with BRAF and KIT inhibitors have increased the demand for molecular testing in melanoma. Furthermore, rapid progress is being made in determining potential new targets, mechanisms of resistance, and developing additional rationally designed therapies. The likely consequence will be a significant expansion of molecular testing for melanoma to include an array of multiple signaling intermediates. Currently, routine testing is mostly limited to BRAF and KIT. Mutations in these genes generally occur in a distinct group of melanoma subsets though, and with the numerous techniques available for mutation analysis, decisions about testing can be complex. The purpose of this review is to provide an overview of clinically relevant mutations which currently guide systemic therapy in Stage IV melanoma, how these molecular events vary with melanoma subtype and primary site of origin, and practical recommendations for testing.

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Section: Methodsmentioning

confidence: 99%

Molecular testing in malignant melanoma

Grossmann¹,

Grossmann²,

Wallander³

2012

Diagnostic Cytopathology

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“…However, it becomes soluble in such solvents after it is subjected to the reaction with trifluoroacetic anhydride (TFAA) which leads to N-trifluoroacetylated derivatives (PA-TFAA). 17 PA-TFAA can then be characterized by SEC using THF as the eluent and PS standard for the calibration. 18,19 PS-co-TMI was directly soluble in THF for SEC measurement.…”

Section: Sec Measurementmentioning

confidence: 99%

In situ control of co‐continuous phase morphology for PS/PS‐co‐TMI/PA6 blend

Zhang

Zuyi

2013

J of Applied Polymer Sci

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The emulsification efficiency of PS-co-TMI, a copolymer polymerized by styrene and 3-isopropenyl-a,a-dimethylbenzene isocyanate (TMI), for polystyrene (PS)/polyamide 6 (PA6) blend was studied. During the mixing process, an effective emulsifier PS-g-PA6 was generated, which was demonstrated by differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy. PS-g-PA6 generated by PS-co-TMI with high TMI content was found to contain some unreacted isocyanate active groups which reduced using efficiency of PS-co-TMI. Irrespective of TMI content in PS-co-TMI, the dosage of PS-co-TMI reached 20 wt %, unreacted PS-co-TMI was detected. These results indicated that reactive emulsification limits for both active groups' content and reactive precursors' dosage. After the rational addition of PS-co-TMI into PS/PA6 system, phase sizes of co-continuous structure were reduced conspicuously. However, co-continuous structure was evolved into matrix-dispersed structure while the dosage of PS-co-TMI reached 20 wt %. Emulsification efficiencies of PS-co-TMI with different TMI contents, 2.2, 4.1, and 7.5 wt %, were compared. The results revealed PS-co-TMI with 2.2 wt % TMI content had the highest reactive emulsification efficiency because of the blockcopolymer-inclined emulsifier generated in the mixing process.

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“…One of the methods to investigate the influence of SSP parameters on the MW and M w /M n of polyamides is the gel permeation chromatography (GPC) test after being modified via trifluoro-acetylation. [23][24][25] Its advantage is directly providing the MW and M w /M n , while the disadvantage is the inconvenient and time consuming operations as well as the harsh solvents. PA1012 is a promising but newly commercialized polyamide, 20,22,26 which belongs to a classic semi-crystalline polymer.…”

Section: Introductionmentioning

confidence: 99%

A rheological method to characterize the molecular weight changes of polyamide 1012 during solid state polymerization

Liu

Wang

Pang

et al. 2022

J of Applied Polymer Sci

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In this study, a fast and convenient method that can characterize the molecular weight (MW) and its distribution (PDI) of polyamide 1012 after the solid-state polymerization (SSP) was proposed with the rheological technique. Conventionally, polyamides have to be chemically modified to become soluble in an organic solvent suitable for the Gel Permeation Chromatography (GPC) measurement. Herein, to avoid the complex operation of chemical modifica-

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Trifluoroacetylation of Amines with N‐Trifluoroacetyl‐Nylon 66

Cited by 22 publications

References 6 publications

Molecular testing in malignant melanoma

Molecular testing in malignant melanoma

In situ control of co‐continuous phase morphology for PS/PS‐co‐TMI/PA6 blend

A rheological method to characterize the molecular weight changes of polyamide 1012 during solid state polymerization

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