Trifluoperazine-Loaded Leciplexes as Potential Nasal Delivery Systems for treatment of depression

Refai, Hanan; Osman, Dina A.; Khalifa, Maha M.; Elsalhy, Soha

doi:10.21608/aijpms.2022.117220.1108

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Although both QAS molecules carry one positive charge, which would result in similar charge densities, the configuration of the different QAS molecules within the vesicular membrane might increase the exposure of the positive charge of DDAB compared to CTAB, thus revealing higher ZP. A similar finding was observed by Refai et al ( 2022) [51]. Regarding the effect of increasing the CHO molar ratio (X 2 ) on the ZP values of the quatsomal formulae, it was found that the ZP values increased by increasing the CHO molar ratio; these results might be due to the negative effect of CHO molar ratio on quatsomes PS where increasing CHO molar ratio led to a significant reduction in quatsomes PS which led to increasing surface ratio and subsequently increased ZP values.…”

Section: Effect Of Formulation Variables On Zeta Potentialsupporting

confidence: 91%

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies

et al. 2023

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This study aims to formulate a buccal mucoadhesive gel containing prednisolone sodium metazoate-loaded quatsomes for efficient localized therapy of recurrent aphthous ulcers. Quatsomes were prepared using a varied concentration of quaternary ammonium surfactants (QAS) and cholesterol (CHO). A 23 factorial design was conducted to address the impact of independent variables QAS type (X1), QAS to CHO molar ratio (X2), and sonication time (X3). The dependent variables were particle size (PS; Y1), polydispersity index (PDI; Y2), zeta potential (ZP; Y3), entrapment efficiency percent (EE%; Y4) and percent of drug released after 6 h (Q6%: Y5). Then, the selected quatsomes formula was incorporated into different gel bases to prepare an optimized mucoadhesive gel to be evaluated via in vivo study. The PS of the developed quatsomes ranged from 69.47 ± 0.41 to 113.28 ± 0.79 nm, the PDI from 0.207 ± 0.004 to 0.328 ± 0.004, ZP from 45.15 ± 0.19 to 68.1 ± 0.54 mV, EE% from 79.62 ± 1.44 to 98.60% ± 1.22 and Q6% from 58.39 ± 1.75 to 94.42% ± 2.15. The quatsomal mucoadhesive gel showed rapid recovery of ulcers, which was confirmed by the histological study and the evaluation of inflammatory biomarkers. These results assured the capability of the developed quatsomal mucoadhesive gel to be a promising formulation for treating buccal diseases.

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Section: Effect Of Formulation Variables On Zeta Potentialsupporting

confidence: 91%

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies

et al. 2023

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“…Using Bruker FTIR (Shimadzu, Japan) and Attenuated Total Reflectance (ATR) technology, the samples were examined. Utilizing FTIR spectral scanning between 400 cm-1 and 4000 cm-1 (19)(20)(21)(22) .…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite

Safa Mohammed Nser,

Athmar Dhahir Habeeb Al-Shohani,

Alaa Abuawad

2023

AJPS

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Superporous hydrogel composite is widely utilized and investigated as a gastro retentive drug delivery system. Materials used in Superporous hydrogel formulation have a profound effect on its properties’, N-methylene bisacrylamide is the crosslinker of choice for the preparation of SPH. The purpose of this study is to determine if using a new high molecular weight crosslinker such as polyethylene glycol diacrylate will affect the physical characteristics of SPH and drug release behavior. For the preparation of super porous hydrogel polyvinyl alcohol, acrylamide, polyethylene glycol diacrylate 700, N, N-Methylene bisacrylamide, sodium bicarbonate, and tween 20 were used. Trifluoperazine HCl was used as a model drug. The buoyancy, porosity, density, drug release, drug content, swelling ratio, and swelling time were studied and compared. All the physical characteristics and medication release profiles were impacted by changing the formulation parameters. The formula with the best physical qualities had 300 µl of acrylamide (40 percent w/v), 20 mg of polyvinyl alcohol, 200 µl of Tween 20 (v/v), 5 µl of polyethylene glycol diacrylate 700, 45 µl ammonium persulfate, 45 µl TEMED and 50 mg of sodium bicarbonate. Around 80% of the drug was released over the course of 12 hours according to zero order kinetics. By modifying the formulation parameters using polyethylene glycol diacrylate, Superporous hydrogel was successfully manufactured and has the best properties to be employed as a gastro retentive drug delivery system.

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Effect of modification of formulation variables on physical characterization of superporouse hydrogel

Safa Mohammed Nser,

Athmar Dhahir Habeeb Al-Shohani

2023

AJPS

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Superporouse hydrogel (SPH) is widely used and investigated as a gastro retentive drug delivery system to extend drug residence time in the stomach However, their mechanical strength represents a problem because they need to withstand the peristaltic movement of the stomach. Properties of SPH are widely affected by the materials used for their synthesis. The aim of the research is to study the effect of changing the foaming agent and foam stabilizer amount on physical properties, in particular mechanical strength, and drug release from SPH. Trifluoperazine HCl will be used as model drug in the study. SPH formulations was prepared using fixed amount of acrylamide (AM) and polyvinyl alcohol (PVA) as monomers, polyethylene glycol diacrylate (PEGDA) as cross-linker, TRFP as model drug and variable amount of sodium bicarbonate (NaHCO3) as foaming agent, and tween 20 as foam stabilizer. Ammonium persulphate (APS) / tetramethyl ethylenediamine (TEMED) system was used as polymerization initiator. The effect of changing foaming agent and foam stabilizer on mechanical strength, buoyancy, porosity, density, drug release, drug content, swelling ratio, and swelling time was investigated. Modifying both factors affected all the physical properties and drug release profile. When tween 20 was increased the mechanical strength, density and floating lag time was increased with a reduction in porosity and drug release. While increasing NaHCO3 reduced mechanical strength, density and floating lag time with increased porosity and faster drug release was observed. Optimum physical properties were observed in formula 2 which had 230 µl of Tween 20 (v/v) and 50 mg of NaHCO3 in which the mechanical strength was 579±0.4, floating lag time 14 min and 80% of the drug was released within 12 hr. As a conclusion SPH with improved mechanical strength, physical properties and drug release pattern can be achieved by changing foam stabilizer and foaming agent amount in the formulations.

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Trifluoperazine-Loaded Leciplexes as Potential Nasal Delivery Systems for treatment of depression

Cited by 3 publications

References 30 publications

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies

Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite

Effect of modification of formulation variables on physical characterization of superporouse hydrogel

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