Triethylene Melamine in the Treatment of Neoplastic Disease

Karnofsky, David A.; Burchenal, Joseph H.; Armistead, G. C.; Southam, Chester M.; Bernstein, JE; Craver, Lloyd F.; Rhoads, C. P.

doi:10.1001/archinte.1951.03810040002001

Cited by 197 publications

(34 citation statements)

References 19 publications

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“…Neurological status and working and life capability were ranged according to values systematized in Karnofsky index (12). In order to test statistical significances and to check the hypotheses we used methods of descriptive and analytical statistics.…”

Section: Methodsmentioning

confidence: 99%

Natural course of the arteriovenous malformations of the brain initially presented by hemorrhage – analysis of a clinical series of 39 patients

Tasić¹,

Jovanović²,

Djurovic³

et al. 2010

Turkish Neurosurgery

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AIm: AVM because of outstanding tendency toward bleeding, even though 20 times more rare then aneurysm on the blood vessels of the brain and her own specific anatomical structure even today represents big neurosurgical challenge. mAterIAl and methOds: Series which is shown here consists of 39 patients which were hospitalized in the institute for neurosurgery of the Clinical Center of Serbia in the period between 1995 and 2004. This group was exposed to symptomatic therapy or it was estimated that surgery, embolization and radio surgery. BulGulAr: Çoklu venöz drenajın tekrarlayıcı kanama gelişmesinde yüksek risk oluşturduğu (p<0.001) saptanmıştır. Çoklu arteriel besleyici bulunması ise çalma fenomenine yol açmaktadır (p<0.05). Hassas bölge yerleşimli ve boyutları 2.5 ile 5 cm arasında olan AVM'lerde eğer çoklu besleyici ve derin drenaj veni var ise, kanama riski artmaktadır (p<0.001).sOnuÇ: AVM'ler diğer damarsal sorunlara göre daha iyi huyludurlar. Her olgu kendi içinde değerlendirilmeli ve cerrahi, embolizasyon ve radyocerrahiden hangisinin uygun olacağına karar verilmelidir.

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Section: Methodsmentioning

confidence: 99%

Natural course of the arteriovenous malformations of the brain initially presented by hemorrhage – analysis of a clinical series of 39 patients

Tasić¹,

Jovanović²,

Djurovic³

et al. 2010

Turkish Neurosurgery

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show abstract

“…In this group, the tumours remained unaltered in size or increased, fresh metastases were discovered, there was failure to gain weight or there was no improvement in the performance status (Karnofsky et al, 1951). Six patients benefited by a temporary arrest of their disease, but there was recurrence of the disease in all cases in under 1 month following cessation of therapy.…”

Section: Selection Of Patientsmentioning

confidence: 85%

A trial of mithramycin in the treatment of advanced malignant disease.

Sewell¹,

Ellis²

1966

Br J Cancer

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“…The exact mechanism by which this influence might be effected in rheumatoid disease is unknown. Paul et al, have recorded Karnofsky's views that the toxic effect of nitrogen mustard on tissues is directly proportional to the rate of mitotic division and the metabolic activity of the tissues (13,3). One would expect, if this is the case, to see a more favorable response in patients with acute, florid synovitis.…”

Section: Discussionmentioning

confidence: 99%

Intra‐Articular Thiotepa in Rheumatoid Disease. A Clinical Analysis of 123 Injected MP and PIP Joints

Ellison

Flatt

1971

Arthritis & Rheumatism

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This report deals with 30 patients with established rheumatoid disease who received an intra-articular injection of Thiotepa into the small joints of the hands. One hundred twenty-three individual joints have been injected, and the follow-up period averages 4.8 years. The study represents a follow-up report on an original trial begun in 1962 by Dr. Adrian E. Flatt at the University of Iowa Hospitals. Our results are assessed on the basis of four parameters: symptomatic pain relief, clinical response to injection, postinjection radiographic progression, and postinjection progression of clinical deformity. An attempt i s made to relate the results to the stage of local disease in the injected joints, as well as t o the systemic disease state in each individual. Only 7 of our 30 patients had a good result when all four parameters were considered. Our analysis of these 7 patients, and our indications for the continued use of Thiotepa are included in this report.

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Triethylene Melamine in the Treatment of Neoplastic Disease

Cited by 197 publications

References 19 publications

Natural course of the arteriovenous malformations of the brain initially presented by hemorrhage – analysis of a clinical series of 39 patients

Natural course of the arteriovenous malformations of the brain initially presented by hemorrhage – analysis of a clinical series of 39 patients

A trial of mithramycin in the treatment of advanced malignant disease.

Intra‐Articular Thiotepa in Rheumatoid Disease. A Clinical Analysis of 123 Injected MP and PIP Joints

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