Tridax Procumbens Extract Loaded Electrospun PCL Nanofibers: A Novel Wound Dressing Material

Suryamathi, Mathiazhagan; Ruba, Chidhambaram; Viswanathamurthi, Periasamy; Velramar, Balasubramanian; Perumal, Pachiappan

doi:10.1007/s13233-019-7022-7

Cited by 33 publications

(13 citation statements)

References 23 publications

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“…graveolens ratio 70/30 (V:V). In a similar study, Suryamathi and his coworkers reported that the average fiber diameter of PCL nanofibers was increased with the encapsulation of Tridax Procumbens Extract [27]. A natural I. graveolens polymer is also a polyelectrolyte polymer, which can release ionic groups such as carboxyl groups in the solution.…”

Section: Resultsmentioning

confidence: 94%

Development of Inula graveolens (L.) Plant Extract Electrospun/Polycaprolactone Nanofibers: A Novel Material for Biomedical Application

et al. 2021

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Recently, there has been a growing interest in research on nanofibrous scaffolds developed by electrospinning bioactive plant extracts. In this study, the extract material obtained from the medicinal plant Inula graveolens (L.) was loaded on polycaprolactone (PCL) electrospun polymeric nanofibers. The combined mixture was prepared by 5% of I. graveolens at 8% (PCL) concentration and electrospun under optimal conditions. The chemical analysis, morphology, and crystallization of polymeric nanofibers were carried out by (FT-IR) spectrometer, scanning electron microscopy (SEM), and XRD diffraction. Hydrophilicity was determined by a contact angle experiment. The strength was characterized, and the toxicity of scaffolds on the cell line of fibroblasts was finally investigated. The efficiency of nanofibers to enhance the proliferation of fibroblasts was evaluated in vitro using the optimal I. graveolens/PCL solutions. The results show that I. graveolens/PCL polymeric scaffolds exhibited dispersion in homogeneous nanofibers around 72 ± 963 nm in the ratio 70/30 (V:V), with no toxicity for cells, meaning that they can be used for biomedical applications.

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Section: Resultsmentioning

confidence: 94%

Development of Inula graveolens (L.) Plant Extract Electrospun/Polycaprolactone Nanofibers: A Novel Material for Biomedical Application

et al. 2021

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“…Generally, when pathogenic microorganisms contaminate skin wounds, the immune system mobilizes its energy trying to suppress the invasion of these pathogens instead of focusing on the re-establishment of the native skin's structural and functional features [1,[4][5][6]. If infection occurs, was used as the main component of the first layer, due to its biocompatibility, desirable mechanical strength, and ability to act as a protective barrier [10,[28][29][30]. On the other hand, the second layer of Poly(vinyl alcohol) (PVA) and Chitosan-Sodium tripolyphosphate (CS-TPP) containing Centella asiatica (L.) (CA) was designed to be in direct contact with the injured skin and enhance the healing process [30,31].…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we produced a novel bionanocomposite dressing membrane with a double-layered structure through electrospinning. Polycaprolactone (PCL), a hydrophobic synthetic polymer, was used as the main component of the first layer, due to its biocompatibility, desirable mechanical strength, and ability to act as a protective barrier [ 10 , 28 , 29 , 30 ]. On the other hand, the second layer of Poly(vinyl alcohol) (PVA) and Chitosan-Sodium tripolyphosphate (CS-TPP) containing Centella asiatica (L.) (CA) was designed to be in direct contact with the injured skin and enhance the healing process [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

2020

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A wide range of naturally derived and synthetic biodegradable and biocompatible polymers are today regarded as promising materials for improving skin regeneration. Alongside this, these materials have been explored in conjunction with different types of antimicrobial and bioactive agents, especially natural-derived compounds, to enhance their biological properties. Herein, a double-layered nanocomposite dressing membrane was fabricated with two distinct layers. A bottom layer from Chitosan-Sodium tripolyphosphate (CS-TPP) and Poly(vinyl alcohol) (PVA) containing Centella asiatica (L.) (CA) was electrospun directly over a Polycaprolactone (PCL) layer to improve the biologic performance of the electrospun nanofibers. In turn, the PCL layer was designed to provide mechanical support to the damaged tissue. The results revealed that the produced double-layered nanocomposite membrane closely resembles the mechanical, porosity, and wettability features required for skin tissue engineering. On the other hand, the in vitro drug release profile of the PCL/PVA_CS-TPP containing CA exhibited a controlled release for 10 days. Moreover, the PVA_CS-TPP_CA’s bottom layer displayed the highest antibacterial activity against Staphylococcus aureus (S. aureus) (99.96 ± 6.04%) and Pseudomonas aeruginosa (P. aeruginosa) (99.94 ± 0.67%), which is responsible for avoiding bacterial penetration while endowing bioactive properties. Finally, the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay showed that this nanocomposite membrane was not cytotoxic for normal human dermal fibroblasts (NHDF) cells. Therefore, these findings suggest the potential use of the double-layered PCL/PVA_CS-TPP_CA as an efficient bionanocomposite dressing material.

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“…Similarly, in (µ + ∂) threshold image (Figure 2b), the sum of the surface and middle layer is visible; therefore the porosity percentage of those layers were calculated. Likewise, (µ − ∂) threshold image (Figure 2c) shows whole of the three layers of EPCL mats, so that the percentage of porosity on all the layers of the mats was calculated (Suryamathi et al, 2019). The porosity percentage of threshold images show surface layer (Figure 2b), sum of the surface and middle layer (Figure 2b) and whole of the three layers (Figure 2c) and the porosity percentage value was found to be 48.7%, 23.3%, and 87.5%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Ecofriendly antimicrobial Acalypha indica leaf extract immobilized polycaprolactone nanofibrous mat for food package applications

Suryamathi

Viswanathamurthi

Amutha

2021

J. Food Process. Preserv.

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A novel antimicrobial food package material was designed by immobilization of medicinal plant Acalypha indica leaf extract on the polycaprolactone (PCL) nanofibrous mats which prevent the food materials from microbial contamination. The morphology of prepared mats was characterized by scanning electron microscope (SEM) images. The loading of plant extract onto the PCL nanofibrous mats was confirmed by XRD spectrum. The porosity percentage of the prepared electrospun PCL nanofibrous mats has been found from SEM image using ImageJ software. The A. indica extract immobilized PCL nanofibrous mats were analyzed for its thermal stability and anti‐bacterial activity. The immobilized nanofibrous mats were tested with food samples (carrot pieces) inoculated in bacterial culture in order to check for their microbial inhibitory effect and monitored its shelf life period. The results of the work declare that the A. indica leaf extract immobilized electrospun PCL nanofibrous mat act as an effective antimicrobial food package material. Practical applications Nowadays, the microbial attack on foods may lead to major health issues worldwide. Many efforts have been taken for preservation and inhibition of such microbial attack on foods. The results of the present work reveal that the package material prepared by immobilization of natural antimicrobial plant extract into polycaprolactone nanofibrous mats vanish the bad odor emerges from foods due to microbial attack and increase the food shelf life period as well as food quality. Therefore, the prepared immobilized nanofibrous mats will serve as a promising package material for foods.

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Tridax Procumbens Extract Loaded Electrospun PCL Nanofibers: A Novel Wound Dressing Material

Cited by 33 publications

References 23 publications

Development of Inula graveolens (L.) Plant Extract Electrospun/Polycaprolactone Nanofibers: A Novel Material for Biomedical Application

Development of Inula graveolens (L.) Plant Extract Electrospun/Polycaprolactone Nanofibers: A Novel Material for Biomedical Application

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

Ecofriendly antimicrobial Acalypha indica leaf extract immobilized polycaprolactone nanofibrous mat for food package applications

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