Tricyclohexylphosphine

CYTOP® 366: A Tertiary Phosphine Inaccessible by Most Traditional Hydrophosphination Methods

“…This includes its use as a constituent of Grubbs catalysts which are employed in metathesis reactions and its use within Crabtree's catalysts used for hydrogenation reactions. [ 2 , 3 ] The simple chemical structure of compound 1 , shown in Figure 1 , may lead a chemist to assume its synthesis at industrial scale is equally straightforward, however manufacture at scale is not without its difficulties. In this paper, we will share an alternative route to compound 1 and the challenges that were overcome to achieve a safe, low‐cost and high‐yielding route, workable at commercial scale.…”

“…Tricyclohexylphosphine ( 1 ), known commercially as CYTOP® 366, is an important ligand used in a plethora of metal‐catalyzed organic transformations. This includes its use as a constituent of Grubbs catalysts which are employed in metathesis reactions and its use within Crabtree's catalysts used for hydrogenation reactions [2,3] . The simple chemical structure of compound 1 , shown in Figure 1, may lead a chemist to assume its synthesis at industrial scale is equally straightforward, however manufacture at scale is not without its difficulties.…”