Triclosan targets miR-144 abnormal expression to induce neurodevelopmental toxicity mediated by activating PKC/MAPK signaling pathway

Diao, Wenqi; Qian, Qiuhui; Sheng, Guangyao; He, Anfei; Yan, Jin; Dahlgren, Randy A.; Wang, Xuedong; Wang, Huili

doi:10.1016/j.jhazmat.2022.128560

Cited by 15 publications

(1 citation statement)

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“…Triclosan can act on GPER to induce estrogen effect. It has been found that triclosan can upregulate the expression of mir-144 by activating GPER, which leads to abnormal regulation of neuro-related genes and neurodevelopmental toxicity, and this process is closely related to the activation of downstream protein kinase C (PKC)/MAPK signaling pathway [28]. In ER-positive breast cancer cells, the activation of GPER and its downstream MAPK/ERK signal pathway increase the expression level of TRIM2 protein, which leads to the reduction of Bim protein in tamoxifenresistant breast cancer cells, providing a new idea for solving tamoxifen resistance in ER-positive breast cancer cells [29].…”

Section: Mitogen-activated Protein Kinase (Mapk) Signaling Pathwaymentioning

confidence: 99%

The Research Advances in G-Protein-Coupled Estrogen Receptor

Zhang¹,

Wang²,

Wang³

2023

Estrogens - Recent Advances

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Estrogen binds to the typical estrogen receptor (ER) ERα or ERβ and is translocated to the nucleus, where it binds directly to the estrogen response element of the target gene to induce transcription and regulate gene expression, and the whole process is completed in several hours to several days. The G protein-coupled estrogen receptor (GPER), a type that is structurally distinct from typical ERα and ERβ, rapidly induces most non-genomic effects within seconds to minutes. GPER regulates cell growth, migration, and programmed cell death in a variety of tissues and has been associated with the progression of estrogen-associated cancers. Here, the characteristics, cell signal transduction, and the latest research progress of GPER in estrogen-associated tumors and retinal diseases are reviewed.

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Section: Mitogen-activated Protein Kinase (Mapk) Signaling Pathwaymentioning

confidence: 99%