Triclosan reduces microsomal prostaglandin E synthase‐1 expression in human gingival fibroblasts

Mustafa, Manal; Wondimu, Biniyam; Yucel‐Lindberg, Tülay; Kats-Hallstrom, A. T.; Jonsson, Anita; Modéer, Thomas

doi:10.1111/j.1600-051x.2004.00622.x

Cited by 26 publications

(27 citation statements)

References 27 publications

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“…Wallet et al [30], for example, showed triclosan to be a potent inhibitor of oral epithelial cell LPS-induced pro-inflammatory responses by regulating the TLR-signaling pathway. Further, Mustafa et al [31] found that triclosan reduced biosynthesis of PGE 2 by inhibiting mPGES-1 in gingival fibroblasts.…”

Section: Resultsmentioning

confidence: 99%

Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years

2014

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BackgroundTriclosan is a broad-spectrum antimicrobial agent used in toothpaste to reduce dental plaque, gingivitis and oral malodor. This community-level assessment evaluated the susceptibility of dental plaque bacteria to triclosan in samples collected over 19 years.MethodsA total of 155 dental plaque samples were collected at eleven different times over 19 years from 58 adults using 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride toothpaste and from 97 adults using toothpaste without triclosan. These included samples from 21 subjects who used triclosan toothpaste for at least five years and samples from 20 control subjects. The samples were cultured on media containing 0, 7.5 or 25 μg/ml triclosan. Descriptive statistics and p values were computed and a linear regression model and the runs test were used to examine susceptibility over time.ResultsGrowth inhibition averaged 99.451% (91.209 - 99.830%) on media containing 7.5 μg/ml triclosan and 99.989% (99.670 - 100%) on media containing 25 μg/ml triclosan. There was no change in microbial susceptibility to triclosan over time discernible by regression analysis or the runs test in plaque samples taken over 19 years including samples from subjects using a triclosan-containing dentifrice for at least five years.ConclusionsThis community-level assessment of microbial susceptibility to triclosan among supragingival plaque bacteria is consistent with the long-term safety of a 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride dentifrice.

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Section: Resultsmentioning

confidence: 99%

Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years

2014

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“…Further, triclosan inhibits IL1-b induced release of PGE 2 from human gingival fibroblasts. Subsequent mechanistic studies examined the mechanism(s) of prostaglandin inhibition (Modeer et al 1996;Mustafa et al 2000;Mustafa et al 2005). Inhibition of mRNA expression and translocation of NF-jB, in relation to PGE 2 production after TNFa mediated induction of gingival fibroblasts were reported.…”

Section: Phenols and Bisphenols As Antibacterial And Anti-inflammatormentioning

confidence: 98%

Antibacterials as anti-inflammatory agents: Dual action agents for oral health

Sreenivasan

Gaffar

2007

Antonie van Leeuwenhoek

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“…This effect may be of particular interest, since it has been shown that TCS also has anti-inflammatory properties. 17,27 Some studies have shown that the daily use of TCS-containing dentifrices reduces the progression of periodontitis, 28 and prevents periodontitis in young populations. 29 The colonization of the subgingival area by bacterial biofilms is essential to the establishment of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a triclosan formula in controlling early subgingival biofilm formation: a randomized trial

et al. 2015

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The aim of this study was to determine the efficacy of rinses with slurries of a dentifrice containing triclosan (TCS), as compared with rinses with slurries from a control dentifrice, in controlling early subgingival biofilm formation. A double-blind, randomized and cross-over clinical trial was designed, and 26 dental students were included. In the first period, participants were randomized to rinse with a TCS slurry or a control slurry, in a 12 h interval, and to refrain from mechanical cleaning. A Plaque Free Zone Index was assessed at 24 h, 48 h, 72 h and 96 h. After a washout period of 10 days, the second experimental period was conducted, following the same protocol as the first period, except that the slurry groups were switched. Use of the TCS slurry resulted in a significantly higher percentage of plaque-free surfaces, both at 24 h and at 72 h (p < 0.01). In the of 48-72 h interval, the triclosan slurry showed a lower percentage of sites converted to a score of 2 (38.1% for the test versus 40% for the control product, p = 0.015).In conclusion, rinsing with slurries of dentifrice containing TCS retards the down growth of bacterial biofilms from the supra-to the subgingival environment.

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Triclosan reduces microsomal prostaglandin E synthase‐1 expression in human gingival fibroblasts

Abstract: The results show that triclosan reduces the augmented biosynthesis of PGE2 by inhibiting the mRNA and the protein expression of mPGES-1 in gingival fibroblasts. This finding may partly explain the anti-inflammatory effect of the agent previously reported in clinical studies.

Cited by 26 publications

References 27 publications

Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years

Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years

Antibacterials as anti-inflammatory agents: Dual action agents for oral health

Efficacy of a triclosan formula in controlling early subgingival biofilm formation: a randomized trial

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