Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine

Effective dentin restorative material based on phosphate-terminated dendrimer as artificial protein

“…We have previously demonstrated that alendronate-conjugated PAMAM dendrimer could induce in situ remineralization of tooth enamel, which is due to the hydroxyapatite-anchored property of alendronate [29]. Meanwhile, we also found that the carboxyl-terminated dendrimer, which has similar structure and self-assembly behavior to that of amelogenin [30], could be immobilized within the collagen matrix and induce intrafibrillar mineralization with hierarchical structure on human dentin [31,32]. However, the chemical structures of above materials are not similar to that of natural NCPs in terms of the peripheral groups.…”

“…It can be a potential restorative material for biomineralized hard tissues such as bone and teeth. Also, due to the well-known encapsulation capability of dendrimer [32,46], it can also be applied to release functional actives while biomineralization.…”

<i>In vivo</i> analyses of the effects of polyamidoamine dendrimer on dentin biomineralization and dentinal tubules occlusion

“…In accordance, it has also been confirmed that G4.0 PAMAM displayed favourable effects on closing the open dentinal tubules in Artificial Saliva (AS) 23) . In addition, the triclosan-loaded G4.0 PAMAM-COOH also can induce in situ remineralization with hierarchical structure on human dentin and release anti-bacterial drug for local treatment at the same time 17) . However, most experiments above of dentin remineralization can, at present, only be evaluated by incubating the samples in Artificial Saliva (AS) 17) , Simulated Body Fluid (SBF) 24) or remineralizing fluid 25) , all of which have problems and limitations.…”

“…In addition, the triclosan-loaded G4.0 PAMAM-COOH also can induce in situ remineralization with hierarchical structure on human dentin and release anti-bacterial drug for local treatment at the same time 17) . However, most experiments above of dentin remineralization can, at present, only be evaluated by incubating the samples in Artificial Saliva (AS) 17) , Simulated Body Fluid (SBF) 24) or remineralizing fluid 25) , all of which have problems and limitations. To observe and evaluate the biological mineralization of the G3.5 PAMAM-COOH on the demineralized dentinal tubules in vivo, the present study used an animal (rat) study model because of the ease of reproducing oral characteristic similar to those of humans.…”

“…PAMAM, often referred to as 'artificial protein', is a new kind of hyperbranched macromolecular nanomaterial that has various functional end groups and topological architecture, which makes it a desirable candidate to mimic the natural NCPs, i.e., sequenstration of mineral ions and subsequent templating capability 14) . It has been recently revealed that different chemical modifications of PAMAM (e.g., carboxyl-terminated PAMAM and amine-terminated PAMAM) can act as an organic template to induce in situ remineralization on tooth enamel or intrafibrillar in artifical saliva or body fluid 13,[15][16][17] . Nevertheless, most of the previous studies focused on the immediate remineralization/occlusion effect of dentinal tubules with little evidence of wheather they could resist daily eating procedures or acidic foods under physicological conditions over time.…”