Triclosan‐induced alteration of gut microbiome and aggravation of asthmatic airway response in aeroallergen‐sensitized mice

Hirota, Ryoji; Ohya, Yukihiro; Yamamoto‐Hanada, Kiwako; Fukutomi, Yuma; Muto, Go; Ngatu, Nlandu Roger; Nakamura, Takuya; Nakamura, Hiroyuki

doi:10.1111/all.13639

Cited by 16 publications

(7 citation statements)

References 9 publications

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“…We would like to expect future prospective cohort study to verify these relationships. Our study recently reported that TCS-exposed mite-sensitized mice showed asthma aggravation and the imbalance of gut microbiota, although mite-sensitized mice did not show asthma aggravation [20]. The mechanism of allergy development by TCS exposure might be led by alternation of microbiota.…”

Section: Discussionmentioning

confidence: 99%

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Mitsui-Iwama

Yamamoto‐Hanada

Fukutomi

et al. 2019

Asia Pacific Allergy

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BackgroundPrevious studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.ObjectivesThe present study was aimed to examine such exposure among Japanese individuals with allergic diseases.MethodsThis cross-sectional study included the International Study of Asthma and Allergies in Childhood questionnaire survey to evaluate allergic outcomes and the collection of urine samples to examine Pb and TCS exposure.ResultsPb containing daily commodities was used in 84.8% children. Pb use was positively associated with current atopic dermatitis (adjusted odds ratio, 4.61; 95% confidence interval, 1.23–17.3). Urinary Pb concentrations were increased significantly in those with current atopic dermatitis (AD) (median, 4.58 vs. 0; p < 0.0001), and showed an increased tendency in those with current wheeze (median, 3.45 vs. 1.81; p = 0.0535) in participants ≤15 years old. Urinary TCS concentration was under the limit of detection in all children.ConclusionUrinary levels of Pb were associated with current AD in children. We should pay more attention about Pb and TCS.

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Section: Discussionmentioning

confidence: 99%

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Mitsui-Iwama

Yamamoto‐Hanada

Fukutomi

et al. 2019

Asia Pacific Allergy

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“…In consistent with previous studies, the decrease of Actinobacteria is associated with asthma and food allergy [ 22 , 24 ]. Enriched class Deltaproteobacteria is related to allergy in mice [ 21 ], and the relative proportion of family Peptostreptococcaceae is correlated positively with total serum IgG and IgE levels that relate to allergy [ 12 ]. Moreover, Lachnospiraceae has been reported to implicate in protection against food allergy through producing acetate, butyrate and propionate to modulate the immune system by inducing Treg cells, DCs precursors and IL-10 production [ 17 , 29 ], while a decrease trend was observed in allergic women in this study.…”

Section: Discussionmentioning

confidence: 99%

Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy

Luo

Nie

et al. 2020

Allergy Asthma Clin Immunol

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Background Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated. Methods Vaginal samples before labor from 12 pregnant women with penicillin allergy and 15 non-allergic pregnant women were collected. Bacterial community structure of all study subjects and the discrepancies between the two groups were analyzed using 16S rRNA sequencing based on Illumina Hiseq 2500 platform. Results The abundant phyla among all participants were Firmicutes, Actinobacteria and Bacteroidetes. The predominant genus was Lactobacillus. Compared to non-allergic pregnant women, Actinobacteria, Coriobacteriaceae, Lachnospiraceae, Paraprevotella and Anoxybacillus significantly decreased, whereas Deltaproteobacteria, Peptostreptococcaceae, Enterococcus and Megamonas were more abundant in penicillin allergic women. Additionally, obvious discrepancies were observed in the co-abundance network at the genus level between the two groups. Conclusions There were differences in the microbial community structure and composition of reproduction tract between penicillin allergic and non-allergic pregnant women. These shifts may be related to maternal and neonatal health.

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“…The exposure concentrations 900 ng/mL of TCS was a 10-fold of the highest urinary TCS concentration in our previous population study in China. While the toxic effects of TCS were well recognized on bacterial resistance, reproductive toxicity and cytotoxicity in aquatic organisms [36][37][38] , the results on thyroid hormone disruption were inconsistent [39,40] .Previous studies found that exposure of TCS decreased thyroid hormone levels and inhibited metamorphosis [39,41] , or did not change the thyroid hormone level nor alter the metamorphosis in anuran [40] . Most animal studies mainly focused on rodents [42,43] .…”

Section: Discussionmentioning

confidence: 99%

Early life Exposure to Triclosan Impacted Thyroid Follicular Structure and Decreased Thyroid Hormone Levels in Zebrafish

Tang¹,

Fan²,

Yu³

et al. 2020

Preprint

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Background: Triclosan (TCS) is an antimicrobial chemical widely used in personal care products. Most of TCS is discharged into aquatic ecosystem after usage. While TCS has potential thyroid-disrupting effect, it is unknown whether early exposure to TCS affects thyroid grand and thyroid hormone levels. We used zebrafish model to examine this topic.Methods: The fertilized zebrafish eggs were exposed to TCS. We inspected hatching and mortality of larvae. The total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured at 7, 14 and 120 days post fertilization (dpf). Thyroid histopathological analysis was conducted at 120 dpf of zebrafish.Results: The hatching rate of embryos decreased from 95.8% in control group to 18.3% in TCS highest exposure in 3 days. In 900 ng/mL TCS exposure all larvae died within one day. With increasing concentration of TCS exposure, TT3 and FT3 level decreased after 14 days. FT4 decreased, and the height and nuclear area of thyroid follicular cell increased with TCS exposure after 120 days.Conclusions: High TCS exposure decreased the hatching rate of zebrafish embryos, and also decreased thyroid hormone levels owing to structural change of thyroid follicles. Our study raised the concern that TCS exposure in early life may profoundly affect neurodevelopment.

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Triclosan‐induced alteration of gut microbiome and aggravation of asthmatic airway response in aeroallergen‐sensitized mice

Cited by 16 publications

References 9 publications

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy

Early life Exposure to Triclosan Impacted Thyroid Follicular Structure and Decreased Thyroid Hormone Levels in Zebrafish

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