Triclosan elicited biochemical and transcriptomic alterations in Labeo rohita larvae

Sharma, Sunil; Dar, Owias Iqbal; Singh, K. Chandramani; Kaur, Arvinder; Faggio, Caterina

doi:10.1016/j.etap.2021.103748

Cited by 39 publications

(12 citation statements)

References 98 publications

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“…The rapid expansion of various types of integrated farming systems for better income and livelihood of farmers is also gaining importance across several developing climes [4]. Though integrated systems require fewer pesticides than the conventional ones, they are used lavishly in co-culture farming techniques [5], the eventual contamination of aquatic ecosystems with PPPs either due to spray-drift, leaching, runoff, and/or accidental spills and from aquacultural applications [6][7][8] could culminate into risks of debilitating effects and mass mortalities of non-target species [9][10][11][12][13][14][15]. In addition, risks of sustained toxicity to local biota due to their persistence and high retention within environmental matrices is also a concern [3,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Following reports of pesticides impacting and shaping the occurrence of global freshwater biodiversity, various criteria based on ecologically relevant risk estimates have been explored to protect aquatic life from pesticide stress [9,14,29,[35][36][37][38][39][40]. Furthermore, the use of integrated biomarker endpoints in evaluating and visualizing chemical exposure effects on aquatic organisms is still not widely applied [41].…”

Section: Introductionmentioning

confidence: 99%

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Chronic Effects of Diazinon® Exposures Using Integrated Biomarker Responses in Freshwater Walking Catfish, Clarias batrachus

Saha¹,

Chukwuka²,

Mukherjee

et al. 2021

Applied Sciences

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Diazinon exposures have been linked to the onset of toxic pathways and adverse outcomes in aquatic species, but the ecological implications on model species are not widely emphasized. The objective of this study was to determine how the organophosphate pesticide diazinon affected hematological (hemoglobin, total red blood count, total white blood count, and mean corpuscular hemoglobin), growth (condition factor, hepatosomatic index, specific growth rate), biochemical (total serum glucose, total serum protein), and endocrine (growth hormone, tri-iodothyronine, and thyroxine) parameters in Clarias batrachus after chronic exposure. Diazinon was administered at predefined exposure doses (0.64 and 1.28 mg/L) and monitored at 15, 30, and 45 days into the investigation. Observation for most biomarkers revealed patterns of decreasing values with increasing toxicant concentration and exposure duration. Correlation analysis highlighted a significant inverse relationship between variables (mean corpuscular hemoglobin, condition factor, specific growth rate, tri-iodothyronine, thyroxine, and total serum protein) and elevated chronic diazinon exposure concentrations. The integrated indices (IBR and BRI) indexes were used to provide visual and understandable depictions of toxicity effects and emphasized the relativity of biomarkers in terms of sensitivity and magnitude or severity of responses under graded toxicant exposures. The significant damage reflected by evaluated parameters in diazinon exposure groups compared to control portends risks to the health of local fish populations, including Clarias batrachus in aquatic systems adjacent to agrarian landscapes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Effects of Diazinon® Exposures Using Integrated Biomarker Responses in Freshwater Walking Catfish, Clarias batrachus

Saha¹,

Chukwuka²,

Mukherjee

et al. 2021

Applied Sciences

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“…Studies in the larvae of Labeo rohita showed that TCS caused biochemical and transcriptomic alterations that resulted in oxidative stress, an impairment of metabolic processes, and dysfunction of the liver, kidney, and digestive system. A total of 96 h exposure to 0.06–0.097 mg/L TCS significantly declined the levels of glucose, triglycerides, urea, and uric acid and the activity of alkaline phosphatase, GOT and GPT [ 238 ].…”

Section: Mechanism Of Action In Pharmacological and Toxicity Studiesmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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“…The structural similarity of TCS to known estrogenic and androgenic endocrine disruptors chemicals, such as polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A, could be predictive of its endocrine disruption potential (Dann & Hontela, 2011; Sharma, Iqbal, Singh, Kaur, & Faggio, 2021). Several studies have shown that this antimicrobial can influence endocrine function in several species, potentially interfering with thyroid hormone homeostasis, reproductive axis, and also brain development (Pernoncini, Montagnini, de Góes, Garcia, & Gerardin, 2018; Rodríguez & Sanchez, 2010; Tran, Jung, Yoo, Lee, & Jeung, 2020; Vijayakumar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Developmental toxicity induced by triclosan exposure in zebrafish embryos

Iannetta

Caioni

Vito

et al. 2022

Birth Defects Research

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Objectives: The present study aimed to investigate the acute toxicity and the developmental alterations induced by triclosan (TCS) exposure in zebrafish early-life stages using fish embryo acute toxicity tests as a methodological approach.Material and Methods: Zebrafish embryos were exposed to five concentrations of TCS and the four lethal alterations were daily recorded to determine the toxicological endpoints of acute toxicity. Furthermore, sublethal alterations were recorded to assess the effect of exposure concentrations on zebrafish embryo's development.Results: The TCS toxicity was determined at 96 h of exposure as lethal concentration 10, lethal concentration 20, lethal concentration 50, lowest observed effects concentration, and no observed effects concentration, reported the following values: 168, 197.2, 267.8, 300, and 200 μg/L. Exposed larvae showed a delay in hatching rate and developed sublethal alterations including reduced blood flow, pericardial oedemata, reduced heartbeat, blood congestion, and craniofacial malformations. The number of zebrafish larvae developing cardiovascular alterations changed according to the tested concentrations and time of evaluation. Conclusion:The data confirmed the developmental toxicity of TCS on aquatic organisms and the sublethal alterations developed by zebrafish larvae, indicated its cardiotoxicity and neurotoxicity. Moreover, the developmental toxicity was strongly influenced by the concentration tested and the number of survived zebrafish developing this alteration varying according to the time of exposure. K E Y W O R D S aquatic toxicology, in vivo model, personal care products toxicity, sublethal alterations 1 | INTRODUCTION Triclosan (5-chloro-2-(2,4-dichloro phenoxy)phenol; TCS) is a nonionic, broad-spectrum antimicrobial used as ingredient in disinfectants, soap, detergent, toothpaste, mouthwash, fabric, deodorant, shampoo, and plastic additives, in addition to innumerable other personal care, veterinary, industrial, and household products (Dann &

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Triclosan elicited biochemical and transcriptomic alterations in Labeo rohita larvae

Cited by 39 publications

References 98 publications

Chronic Effects of Diazinon® Exposures Using Integrated Biomarker Responses in Freshwater Walking Catfish, Clarias batrachus

Chronic Effects of Diazinon® Exposures Using Integrated Biomarker Responses in Freshwater Walking Catfish, Clarias batrachus

Triclosan: A Small Molecule with Controversial Roles

Developmental toxicity induced by triclosan exposure in zebrafish embryos

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