Triclosan-coated sutures for the prevention of surgical-site infections: a meta-analysis

Konstantelias, Athanasios A.; Andriakopoulou, Chrysi Stefania I; Mourgela, Sofia

doi:10.1080/00015458.2017.1287396

Cited by 17 publications

(8 citation statements)

References 43 publications

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“…Our results support the findings of Konstantelias et al who concluded that triclosan-coated sutures were associated with a significantly lower risk of SSI when compared with standard sutures 32 61. In addition, the authors concluded that triclosan-coated sutures significantly reduced the risk of SSI in clean, clean-contaminated and contaminated surgery; in agreement with our findings 61. de Jonge et al reported a meta-analysis of 21 RCTs including 6462 patients, also concluding that triclosan-coated sutures significantly reduced the risk of SSI compared with standard sutures 32.…”

Section: Discussionsupporting

confidence: 93%

“…There have been 11 previous reviews in this topic area, the results of these reviews have been summarised in table 2 27 28 30–32 58–63. Our results support the findings of Konstantelias et al who concluded that triclosan-coated sutures were associated with a significantly lower risk of SSI when compared with standard sutures 32 61. In addition, the authors concluded that triclosan-coated sutures significantly reduced the risk of SSI in clean, clean-contaminated and contaminated surgery; in agreement with our findings 61.…”

Section: Discussionsupporting

confidence: 91%

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The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature

et al. 2019

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Introduction and objectivesSurgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures aimed at reducing SSIs. Our objective is to update the existing literature by systematically reviewing available evidence to assess the effectiveness of triclosan-coated sutures in the prevention of SSIs.MethodsA systematic review of EMBASE, MEDLINE, AMED (Allied and complementary medicine database) and CENTRAL was performed to identify full text randomised controlled trials (RCTs) on 31 May 2019.InterventionTriclosan-coated sutures versus non-triclosan-coated sutures.Primary outcomeOur primary outcome was the development of SSIs at 30 days postoperatively. A meta-analysis was performed using a fixed-effects model.ResultsTwenty-five RCTs were included involving 11 957 participants. Triclosan-coated sutures were used in 6008 participants and non triclosan-coated sutures were used in 5949. Triclosan-coated sutures significantly reduced the risk of SSIs at 30 days (relative risk 0.73, 95% CI 0.65 to 0.82). Further sensitivity analysis demonstrated that triclosan-coated sutures significantly reduced the risk of SSIs in both clean and contaminated surgery.ConclusionTriclosan-coated sutures have been shown to significantly reduced the risk of SSIs when compared with standard sutures. This is in agreement with previous work in this area. This study represented the largest review to date in this area. This moderate quality evidence recommends the use of triclosan-coated sutures in order to reduce the risk of SSIs particularly in clean and contaminated surgical procedures.PROSPERO registration numberCRD42014014856

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature

et al. 2019

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“…Konstantelias et al [39] analyzed 30 studies (19 randomized, 11 non-randomized; 15,385 procedures) giving evidence that triclosan-coated sutures were associated with a lower risk of SSIs (risk ratio [RR] = 0.68; 95% confidence interval [CI] 0.57-0.81). Triclosan-coated sutures were associated with a lower risk for SSIs in high-quality randomized studies (Jadad score 4 or 5).…”

Section: Resultsmentioning

confidence: 99%

Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Simone¹,

Sartelli

Coccolini

et al. 2020

World J Emerg Surg

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Background: Surgical site infections (SSI) represent a considerable burden for healthcare systems. They are largely preventable and multiple interventions have been proposed over past years in an attempt to prevent SSI. We aim to provide a position paper on Operative Room (OR) prevention of SSI in patients presenting with intraabdominal infection to be considered a future addendum to the well-known World Society of Emergency Surgery (WSES) Guidelines on the management of intra-abdominal infections. Methods: The literature was searched for focused publications on SSI until March 2019. Critical analysis and grading of the literature has been performed by a working group of experts; the literature review and the statements were evaluated by a Steering Committee of the WSES.Results: Wound protectors and antibacterial sutures seem to have effective roles to prevent SSI in intra-abdominal infections. The application of negative-pressure wound therapy in preventing SSI can be useful in reducing postoperative wound complications. It is important to pursue normothermia with the available resources in the intraoperative period to decrease SSI rate. The optimal knowledge of the pharmacokinetic/pharmacodynamic characteristics of antibiotics helps to decide when additional intraoperative antibiotic doses should be administered in patients with intra-abdominal infections undergoing emergency surgery to prevent SSI.Conclusions: The current position paper offers an extensive overview of the available evidence regarding surgical site infection control and prevention in patients having intra-abdominal infections.

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“…Nine meta-analyses were identified from database searching [28,29,[33][34][35][36][37][38][39] (Table 2). After the critical appraisal of all publications, Henriksen et al was selected as the latest meta-analysis that best matched the inclusion and exclusion criteria [28].…”

Section: Clinical Resultsmentioning

confidence: 99%

The Clinical and Economic Value of Triclosan-Coated Surgical Sutures in Abdominal Surgery

et al. 2020

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Surgical site infection (SSI) is a frequent complication of surgical procedures. The aim of this study was to analyze the clinical evidence for SSI prevention with triclosan-coated sutures (TCS) in abdominal surgery and to investigate the economic impact of TCS in this type of procedure compared with conventional absorbable sutures (CS). A literature review was carried out to identify meta-analyses that were published between 1990 and 2019 that assessed the use of TCS in abdominal surgery. A budget impact analysis was performed from an Italian hospital perspective based on the most recently published evidence to simulate the financial impact of TCS in a general surgery unit. Uncertainty was explored through scenario analysis, as well as deterministic and probabilistic sensitivity analyses. Nine meta-analyses and two additional randomized clinical trials were retrieved. All meta-analyses described a reduction (range 19%–44%) in the risk of SSI when TCS were used. The use of TCS was associated with an overall annual net saving for the general surgery unit of €14,785 and a reduction of 3.2 SSIs compared with CS. Sensitivity analyses resulted in a positive annual saving associated with TCS in 98% of scenarios. TCS are a valuable, cost-saving SSI prevention strategy. TCS additional costs would be offset by the reduction in SSIs.

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Triclosan-coated sutures for the prevention of surgical-site infections: a meta-analysis

Abstract: Further randomized studies are needed to confirm the role of TCS in specific surgical procedures and whether or not they are related with lower risk for mortality.

Cited by 17 publications

References 43 publications

The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature

The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature

Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

The Clinical and Economic Value of Triclosan-Coated Surgical Sutures in Abdominal Surgery

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