Triclosan coated sutures: an overview of safety and efficacy in reducing risk of surgical site infection

Sewlikar, Sandeep; Pillai, Reshmi; Mahajan, Nilesh; Desai, Anish

doi:10.5455/2349-2902.isj20150201

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…Bioactive compounds, such as eugenol, are a promising alternative to triclosan, which has demonstrated doubtful effectiveness for some surgical interventions (Sewlikar et al, 2015). Furthermore, triclosan has been classified as an "emerging environmental contaminant", that has been directly related to the spreading of antibiotic resistance in clinically important strains (Carey and McNamara, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Since 2002, Vicryl Plus was the first commercial antimicrobial suture approved by the US Food and Drug Administration (US FDA), and since then, this suture was clinically used as a useful alternative to decrease the risk factors for Surgical Site Infection (SSI), risk, even in oral surgery (Venema et al, 2011;Hoshino et al, 2013;Sewlikar et al, 2015). However, the efficacy of this suture is still unclear, and its clinical efficacy has been questioned in randomized controlled trials (Wu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Streptococcus mutans (ATCC 25175) biofilm formation on eugenol-impregnated surgical sutures

Victor¹,

Elaine²,

Maria³

et al. 2019

Afr. J. Microbiol. Res.

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The use of bioactive compounds as anti-infective coating on biomaterial surfaces has been studied as a tool against microbial adhesion and the establishment of biofilms. The objective of this work was to evaluate the antibacterial activity of eugenol, specifically the ability to interact with cotton suture threads for preventing adhesion and biofilm formation of Streptococcus mutans (ATCC 25175). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of eugenol were determined according to Clinical and Laboratory Standards Institute (CLSI), which showed respective concentration values of 250 and 1000 μg/ml. In addition, eugenol displayed marked activity against to biofilm formation in 96-well polystyrene plates against several strains from the Streptococcus genus, even at lower than bacteriostatic concentrations between 15 to 250 μg/ml. Moreover, eugenol formed an effective covering on cotton-suture surfaces that inhibited cell adhesion, which decreased the S. mutans (ATCC 25175) biofilm development, according to biomass and metabolic rate, quantified by crystal violet staining and XTT reduction, respectively. This research may help to explore the eugenol molecule as an antifouling coating on surfaces, bringing a new perspective to the prevention of infections associated with biomaterials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Streptococcus mutans (ATCC 25175) biofilm formation on eugenol-impregnated surgical sutures

Victor¹,

Elaine²,

Maria³

et al. 2019

Afr. J. Microbiol. Res.

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“…At high concentrations, triclosan provokes membrane permeability and non-speci c membrane damage (29). In hospitals, triclosan is used as an MRSA decolonisation therapy (30), antimicrobial hand wash (30), antiseptic ointment (31), and is impregnated into surgical sutures (32) and urinary catheters (33). Triclosan is also widely used in domestic settings, being found in many household products including soaps, toothpastes (34), cosmetics and laundry detergents (35).…”

Section: Introductionmentioning

confidence: 99%

Triclosan alters biofilm structures and confers antibiotic tolerance in Staphylococcus aureus using multiple regulatory pathways

Hardie,

Walsh,

Salzer

et al. 2024

Preprint

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The biocide triclosan is used extensively in both household and hospital settings. The chronic exposure to the biocide occurring in individuals that use triclosan-containing products results in low levels of triclosan present in the human body that has been linked to induction of antibiotic tolerance and altered biofilm formation. Here we aimed to unravel the molecular mechanisms involved in triclosan-induced antibiotic tolerance and biofilm formation in Staphylococcus aureus. Triclosan treatment prior to planktonic exposure to bactericidal antibiotics resulted in 1,000 fold higher viable cell counts compared to non-pretreated cultures. Triclosan pretreatment also protected S. aureus biofilms against otherwise lethal doses of antibiotics as shown by live/dead cell staining and viable cell counting. Triclosan mediated antibiotic tolerance in S. aureus biofilms required an active stringent response because biofilms of a pppGpp0 strain were not protected from antibiotic killing. Incubation of S. aureus with triclosan also altered biofilm structure due to SarA-mediated overproduction of the polysaccharide intercellular adhesin (PIA) in the biofilm matrix. Thus, physiologically relevant concentrations of triclosan can trigger (p)ppGpp dependent antibiotic tolerance as well as SarA dependent biofilm formation.

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“…At high concentrations, triclosan provokes membrane permeability and non-specific membrane damage (28). In hospitals, triclosan is used as an MRSA decolonisation therapy (29), antimicrobial hand wash (29), antiseptic ointment (30), and is impregnated into surgical sutures (31) and urinary catheters (32). Triclosan is also widely used in domestic settings, being found in many household products including soaps, toothpastes (33), cosmetics and laundry detergents (34).…”

Section: Introductionmentioning

confidence: 99%

The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures inStaphylococcus aureus

Walsh

Salzer

Wolz

et al. 2023

Preprint

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The biocide triclosan is used extensively in both household and hospital settings. The chronic exposure to the biocide occurring in individuals that use triclosan-containing products results in low levels of triclosan present in the human body that has been linked to induction of antibiotic tolerance and altered biofilm formation. Here we aimed to unravel the molecular mechanisms involved in triclosan induced antibiotic tolerance and biofilm formation in Staphylococcus aureus. Triclosan treatment prior to planktonic exposure to bactericidal antibiotics resulted in 1,000 fold higher viable cell counts compared to non-pretreated cultures. Triclosan pretreatment also protected S. aureus biofilms against otherwise lethal doses of antibiotics as shown by live/dead cell staining and viable cell counting. Triclosan mediated antibiotic tolerance in planktonic and biofilm cultures required an active stringent response because a pppGpp0 strain was not protected from antibiotic killing. Incubation of S. aureus with triclosan also altered biofilm structure due to SarA-mediated overproduction of the polysaccharide intercellular adhesin (PIA) in the biofilm matrix. Thus, physiologically relevant concentrations of triclosan can trigger (p)ppGpp dependent antibiotic tolerance as well as SarA dependent biofilm formation.

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Triclosan coated sutures: an overview of safety and efficacy in reducing risk of surgical site infection

Cited by 13 publications

References 15 publications

Inhibition of Streptococcus mutans (ATCC 25175) biofilm formation on eugenol-impregnated surgical sutures

Inhibition of Streptococcus mutans (ATCC 25175) biofilm formation on eugenol-impregnated surgical sutures

Triclosan alters biofilm structures and confers antibiotic tolerance in Staphylococcus aureus using multiple regulatory pathways

The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures inStaphylococcus aureus

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