Triclosan-beschichtete Nahtmaterialien in der kolorektalen Chirurgie

Hunger, Richard; Mantke, Anne; Herrmann, Christian; Mantke, René

doi:10.1007/s00104-018-0732-0

Cited by 8 publications

(4 citation statements)

References 50 publications

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“…Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a bactericidal and antifungal agent that is ubiquitously incorporated into thousands of industrial and consumer products including clothing, toys, cleaning supplies, personal care products (i.e., soap, shampoo, toothpaste, etc. ), and surgical soaps and sutures (52, 53) with 10.5 million pounds produced globally in 2015 (53). Triclosan and triclocarban (TCC), another widely used antibacterial in PPCPs, are the most common, broad-spectrum antimicrobial agents used in household items and PPCPs (54).…”

Section: Pharmaceuticals and Personal Care Productsmentioning

confidence: 99%

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

et al. 2019

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Aquatic and terrestrial environments are increasingly contaminated by anthropogenic sources that include pharmaceuticals, personal care products, and industrial and agricultural chemicals (i. e., pesticides). Many of these substances have the potential to disrupt endocrine function, yet their effect on thyroid hormone (TH) action has garnered relatively little attention. Anuran postembryonic metamorphosis is strictly dependent on TH and perturbation of this process can serve as a sensitive barometer for the detection and mechanistic elucidation of TH disrupting activities of chemical contaminants and their complex mixtures. The ecological threats posed by these contaminants are further exacerbated by changing environmental conditions such as temperature, photoperiod, pond drying, food restriction, and ultraviolet radiation. We review the current knowledge of several chemical and environmental factors that disrupt TH-dependent metamorphosis in amphibian tadpoles as assessed by morphological, thyroid histology, behavioral, and molecular endpoints. Although the molecular mechanisms for TH disruption have yet to be determined for many chemical and environmental factors, several affect TH synthesis, transport or metabolism with subsequent downstream effects. As molecular dysfunction typically precedes phenotypic or histological pathologies, sensitive assays that detect changes in transcript, protein, or metabolite abundance are indispensable for the timely detection of TH disruption. The emergence and application of ‘omics techniques—genomics, transcriptomics, proteomics, metabolomics, and epigenomics—on metamorphosing tadpoles are powerful emerging assets for the rapid, proxy assessment of toxicant or environmental damage for all vertebrates including humans. Moreover, these highly informative ‘omics techniques will complement morphological, behavioral, and histological assessments, thereby providing a comprehensive understanding of how TH-dependent signal disruption is propagated by environmental contaminants and factors.

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Section: Pharmaceuticals and Personal Care Productsmentioning

confidence: 99%

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

et al. 2019

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“…In addition, Henriksen's meta-analysis evaluated several forms of surgery, including elective open colorectal surgery, elective midline laparotomy, open appendectomy, and even faecal peritonitis laparotomies [22,25]. In their meta-analyses, Edmiston et al, Chang et [21,22,[26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Triclosan-antibacterial sutures impact on the incidence of surgical site infection in laparoscopic sleeve gastrectomy, laparoscopic appendectomy, or laparoscopic cholecystectomy: a multicenter, double-blind, randomised study

Erfan

Thabet

Mohy

et al. 2023

Preprint

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Background: Surgical site infection (SSI) is a common and major cause of post-operative morbidity. Port site infection is a subgroup of SSI occurring at the ports of laparoscopy. Most experts agree that surgical sites that do not harbour purulent fluid are not infected, but the lack of agreement otherwise means that any retrospective study of SSI is essentially unreliable and useless if it relies upon observation or antibiotic administration as diagnostic criteria. Methods: In our study, 912 individuals were eligible for laparoscopic cholecystectomy, appendicectomy, or sleeve operations. The study group (polyglactin 910 suture coated with triclosan) included 456 patients. The control group (polyglactin 910 suture) had 456 patients. Results: The incidence of PSI was significantly lower in the triclosan group than the control group (OR 0.31; 95% CI 0.2–0.49; NNT = 9.79). Conclusion: Prospective studies must ensure that criteria for the appearance of the incision are explicit before the study starts and that all observers are trained. Trial registration: ClinicalTrials.gov Identifier: NCT04255927

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“…20,23 Other meta-analyses pooled all available randomized controlled trials without categorizing the risk by wound class, kind of operation, or organ or apparatus implicated. 19,20,[24][25][26][27][28][29] Different studies have been conducted and demonstrated the superiority of triclosan. In vitro, preclinical studies have demonstrated that coated polyglactin 910 sutures effectively inhibit the growth of Staphylococcus aureus, Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Henriksen's meta‐analysis evaluated several forms of surgery, including elective open colorectal surgery, elective midline laparotomy, open appendicectomy and even faecal peritonitis laparotomies 20,23 . Other meta‐analyses pooled all available randomized controlled trials without categorizing the risk by wound class, kind of operation, or organ or apparatus implicated 19,20,24–29 …”

Section: Discussionmentioning

confidence: 99%

The effect of triclosan‐coated sutures on the incidence of surgical site infection in laparoscopic sleeve gastrectomy, laparoscopic appendicectomy or laparoscopic cholecystectomy: A multi‐centre, double‐blind, randomized, intra‐individual study

Erfan,

Thabet,

Rageh

et al. 2023

International Wound Journal

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Surgical site infection (SSI) is a common cause of post‐operative morbidity. According to the latest report announced by CDC, the SSI accounts for 20% of healthcare‐associated infection with a high risk of mortality up to twofold to 11‐fold increase with high economic burden for the prolonged hospital stay. Port site infection (PSI) is a subgroup of SSI occurring at the ports of laparoscopy. We tried to determine the efficacy of polyglactin 910 suture coated with triclosan in lowering the rate of PSI in some of the clean‐contaminated wound surgeries. This study included 480 individuals eligible for laparoscopic cholecystectomy, appendicectomy or sleeve operations. Polyglactin 910 sutures coated with triclosan were used in one port site incision while polyglactin 910 sutures were used in the other port sites incisions. In patients who underwent laparoscopic cholecystectomy and appendicectomy, the incidence of PSI was significantly lower in the triclosan‐coated sutures. In sleeve gastrectomy patients, although a lower number of triclosan‐coated sutures developed PSI, there was no statistically significant difference between triclosan and non‐triclosan‐coated sutures. This study showed that using sutures coated with antiseptics like triclosan has clinical benefits to prevent SSIs in most of the laparoscopic surgeries.

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Triclosan-beschichtete Nahtmaterialien in der kolorektalen Chirurgie

Abstract: Against the background of a moderate to high risk of bias and the partially contradictory findings of the studies, the general recommendation of the WHO on the use of triclosan-coated sutures for colorectal surgery could not be confirmed.

Cited by 8 publications

References 50 publications

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

Triclosan-antibacterial sutures impact on the incidence of surgical site infection in laparoscopic sleeve gastrectomy, laparoscopic appendectomy, or laparoscopic cholecystectomy: a multicenter, double-blind, randomised study

The effect of triclosan‐coated sutures on the incidence of surgical site infection in laparoscopic sleeve gastrectomy, laparoscopic appendicectomy or laparoscopic cholecystectomy: A multi‐centre, double‐blind, randomized, intra‐individual study

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