Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms

Li, Huitao; Yu, Zhiwen; Chen, Lanlan; Su, Ying; Li, Xiaoheng; Jin, Lixu; Ge, Ren‐Shan

doi:10.1155/2017/8284097

Cited by 19 publications

(11 citation statements)

References 22 publications

(24 reference statements)

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“…Reduced progesterone and estradiol levels might indicate reduced ovarian function. Despite TCC presenting estrogenic (Ahn et al, ; Huang et al, ; Tarnow et al, ) and anti‐estrogenic activity in vitro (Li et al, ), our present results did not demonstrate any effect of TCC exposure on the hormone‐dependent endpoints in female offspring. Our present results indicated that there was no impairment in the histology of the uterus or ovary.…”

Section: Discussioncontrasting

confidence: 72%

“…In addition, there was a decrease in progesterone levels in the adult female offspring exposed to TCC 3.0, as well as a decrease in estradiol levels in the TCC 0.3 and 3.0 groups in adulthood. In rodents, the main period of differentiation and maturation of the uterus occurs after birth (Brody & Cunha, 1989) (Ahn et al, 2008;Huang et al, 2014;Tarnow et al, 2013) and anti-estrogenic activity in vitro (Li et al, 2017), our present results did not demonstrate any effect of TCC exposure on the hormonedependent endpoints in female offspring. Our present results indicated that there was no impairment in the histology of the uterus or ovary.…”

Section: Discussioncontrasting

confidence: 65%

“…Moreover, in vitro studies have also shown enhanced estrogen activity mediated via the estrogen receptor (ER) (Ahn et al, 2008;Tarnow, Tralau, Hunecke, & Luch, 2013) and weak estrogenic activity in the ER reporter gene assay and breast cancer cell line (MCF-7) proliferation assay (Huang et al, 2014). Tonoli et al (2015) reported that TCC exposure altered an early step in adrenal steroidogenesis in H295R cells, and human aromatase inhibition in vitro (Li et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring

Costa

Borges

Cavalcanti

et al. 2019

J of Applied Toxicology

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Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8–11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post‐natal day 21 and included in the study. No litter‐mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre‐implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring

Costa

Borges

Cavalcanti

et al. 2019

J of Applied Toxicology

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“…2014 ). In another example, the chlorinated phenol TCS has been shown to inhibit the aromatase enzyme CYP19A1 in vitro , which can alter production of estradiol ( Li et al. 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Aung

Ferguson

et al. 2021

Environ Health Perspect

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Background: Humans are exposed to mixtures of toxicants that can impact several biological pathways. We investigated the associations between multiple classes of toxicants and an extensive panel of biomarkers indicative of lipid metabolism, inflammation, oxidative stress, and angiogenesis. Methods: We conducted a cross-sectional study of 173 participants (median 26 wk gestation) from the LIFECODES birth cohort. We measured exposure analytes of multiple toxicant classes [metals, phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs)] in urine samples. We also measured endogenous biomarkers (eicosanoids, cytokines, angiogenic markers, and oxidative stress markers) in either plasma or urine. We estimated pair-wise associations between exposure analytes and endogenous biomarkers using multiple linear regression after adjusting for covariates. We used adaptive elastic net regression, hierarchical Bayesian kernel machine regression, and sparse-group LASSO regression to evaluate toxicant mixtures associated with individual endogenous biomarkers. Results: After false-discovery adjustment ( ), single-pollutant models yielded 19 endogenous biomarker signals associated with phthalates, 13 with phenols, 17 with PAHs, and 18 with trace metals. Notably, adaptive elastic net revealed that phthalate metabolites were selected for several positive signals with the cyclooxygenase ( ), cytochrome p450 ( ), and lipoxygenase ( ) pathways. Conversely, the toxicant classes that exhibited the greatest number of negative signals overall in adaptive elastic net were phenols ( ) and metals ( ). Discussion: This study characterizes cross-sectional endogenous biomarker signatures associated with individual and mixtures of prenatal toxicant exposures. These results can help inform the prioritization of specific pairs or clusters of endogenous biomarkers and exposure analytes for investigating health outcomes. https://doi.org/10.1289/EHP7396

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“…Both Triclosan and its equivalent triclocarban have also been demonstrated to inhibit human aromatase [73] and to be associated with diminished antral follicle counts in humans.…”

Section: Other Preservatives/antimicrobialsmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms

Cited by 19 publications

References 22 publications

In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring

In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches

Endocrine Disruption by Mixtures in Topical Consumer Products

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