Triclinic Form of Tetraaqua(orotato-N,O)magnesium(II) Hydrate at 153K

Mutikainen, Ilpo; Hämäläinen, Reijo; Klinga, Martti; Orama, Olli; Turpeinen, Urho

doi:10.1107/s0108270196006567

Cited by 19 publications

(16 citation statements)

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“…1) has been studied [1][2][3][4][5][6][7][8][9][10][11][12][13][14] in the area ranging from bioinorganic to pharmaceutical and materials chemistry. Orotic acid occupies a unique position in biology by being the only effective precursor in the biosynthesis of pyrimidine bases of nucleic acids in living organisms [15,16].…”

Section: Introductionmentioning

confidence: 99%

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

2006

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Section: Introductionmentioning

confidence: 99%

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

2006

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“…36 In some cases, mixed coordination modes are observed where the orotate anion acts as a bridging ligand to form polymeric structures. In [Mn 2 (HL ) 2 (H 2 O) 6 ], for example, polymeric chains result where the HL 2− anion links three manganese atoms via O3-N1, O1 and O4. 37 One rare example of N3 coordination is found in hexaamine bis (5- chelates one Fe(III) by the bidentate O3-N1 mode and is bonded to a second Fe(III) through the adjacent carbonyl oxygen atom.…”

Section: Introductionmentioning

confidence: 99%

New cerium(III) and neodymium(III) complexes as cytotoxic agents

Kostova

Rastogi

Kiefer

et al. 2006

Appl. Organometal. Chem.

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The cerium(III) and neodymium(III) complexes of 5-aminoorotic acid were synthesized and characterized by means of spectral data (IR, Raman, 1 H NMR and 13 C NMR) and elemental analysis. Significant differences in the IR spectra of the complexes were observed as compared with the spectrum of the ligand. A comparative analysis of the Raman spectra of the complexes with that of the free 5-aminoorotic acid allowed a straightforward assignment of the vibrations of the ligand groups involved in coordination. 1 H NMR and 13 C NMR spectra confirmed the formation of the complexes. The ligand and the complexes were tested for the cytotoxic activities on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein, and the non-Hodgkin lymphoma-derived DOHH-2, characterized by a rexpression of the antiapoptotic protein bcl-2 cell lines. The results obtained indicate that the tested compounds exerted a considerable cytotoxic activity upon the evaluated cell lines in a concentration-dependent manner, which enabled the construction of dose-response curves and the calculation of the corresponding IC 50 values. Cytotoxicity towards tumor cells was determined for a broad concentration range. The inorganic salts exerted a very weak cytotoxic effect on these cells that is in contrast to the lanthanide complexes, which exhibited potent cytotoxic activity towards K-562 and DOHH-2 cell lines.

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“…It helps with the production of genetic material and is an intermediate in pyrimidine metabolism [4]. The literature lists many reports on mononuclear [5][6][7][8][9][10] and polymeric [11][12][13][14][15][16] orotate complexes. Nicotinamide (2) is a form of vitamin B3 and is an important component of several enzymes [17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of transition metal-vitamin B13 complexes mixed with a co-vitamin

Köse

Zümreoǧlu‐Karan

Ünaleroğlu

et al. 2006

Journal of Coordination Chemistry

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The synthesis and structural characterization of mixed vitamin-metal complexes are reported. A complex bearing two vitamins (B3 and B13) on the same metal centre, nicotinamide(orotato)nickel(II) pentahydrate, has been prepared and characterised by single-crystal X-ray diffraction methods. A complex of Cr(III) with vitamins C and B13, bis(ascorbato)orotatochromium(III) dihydrate, has been isolated and its nature investigated by means IR, 13 C NMR, API-ES and thermogravimetric measurements. Theoretical calculations have been performed to propose a structure in accord with results obtained.

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Triclinic Form of Tetraaqua(orotato-N,O)magnesium(II) Hydrate at 153K

Cited by 19 publications

References 0 publications

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

New cerium(III) and neodymium(III) complexes as cytotoxic agents

Synthesis and characterization of transition metal-vitamin B13 complexes mixed with a co-vitamin

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